Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS

Paschou, Stavroula Α.; Palioura, Eleni; Ioannidis, Dimitrios; Anagnostis, Panagiotis; Panagiotakou, Argyro; Loi, Vasiliki; Karageorgos, Georgios; Goulis, Dimitrios G.; Vryonidou, Andromachi

doi:10.1530/ec-17-0239

Cited by 23 publications

(16 citation statements)

References 31 publications

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“…Another crucial steroid hormone produced by the adrenal cortices is DHEA-S [41], which together with dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in the human body [42]. The association between DHEA-S concentration and metabolic disturbances during PCOS is controversial [43]. A study conducted by Paschou et al [43] revealed that the concentration of DHEA-S was not associated with significant alteration in lipids profile parameters, despite the higher concentrations of TT and AD, whereas a study conducted by Meirow et al [44] showed that the concentration of DHEA-S was positively correlated with the level of CHO, LDL-C, and TG, and negatively with HDL-C in the blood of patients with IR.…”

Section: Discussionmentioning

confidence: 99%

The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome

Bizoń

Franik

Niepsuj

et al. 2021

JCM

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We aimed to evaluate the relationship between selected serum sex hormones and lipid profiles in a group of women with polycystic ovary syndrome (PCOS) dividing according to four phenotypes, value of body mass index (BMI), and presence of hyperlipidemia. The study included 606 Caucasian women. Lipids and selected hormones were estimated using commercially available procedures during hospitalization in 2017. Phenotype of PCOS, BMI value, and hyperlipidemia were significant factors that influenced androgen hormone concentrations, such as total and free testosterone and androstenedione as well as the value of free androgen index (FAI). Moreover, significant changes in concentrations of dehydroepiandrosterone sulphate and sex hormone binding globulin (SHBG) were found between those groups. Higher quartiles of triglyceride concentrations increased the odds ratio of decreased concentrations of SHBG or increased values of FAI, while an adverse relation was found in case of HDL-C. The concentration of estradiol in the blood of women with PCOS was not associated with lipid profile parameters in any investigated groups. Probably, irregularities in sex hormone concentrations during PCOS is not directly associated with lipid profile parameters but could be reflective of the concentration of SHBG or the ratio of SHBG and total testosterone and their association with lipids.

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Section: Discussionmentioning

confidence: 99%

The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome

Bizoń

Franik

Niepsuj

et al. 2021

JCM

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“…PCOS is accompanied by a higher incidence of hypertension, insulin resistance and lipid profile abnormalities, resulting in an adverse cardiovascular profile (8–12); a higher prevalence of glucose dysregulation, manifesting as impaired fasting glucose or type 2 diabetes (13, 14); and obesity. However, it is recognized that within the PCOS phenotype there are a number of different androgenic and insulin resistant profiles (15, 16).…”

Section: Introductionmentioning

confidence: 99%

Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome

et al. 2019

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Objective: To correlate features of metabolic syndrome with creatine kinase (CK) in women with and without polycystic ovary syndrome (PCOS).Design: Comparative cross-sectional analysis.Methods: Demographic and metabolic data from Qatari women aged 18–40 years from the Qatar Biobank (97 diagnosed with PCOS, 563 controls). The primary outcome was the association between plasma CK and features of metabolic syndrome.Results: CK increased when the waist circumference was >80 cm (p < 0.015) and when associated with 2 or more features of the metabolic syndrome (p < 0.01). CK correlated with BMI (p < 0.003) but not with waist/hip ratio. Overall, CK did not differ between PCOS and controls, rising equally in both as body mass index (BMI) increased. C reactive protein (CRP) was higher in obese PCOS (P < 0.05) compared to controls, but did not correlate with CK (p > 0.05).Conclusion: CK was associated with an increase in BMI, waist circumference >80 cm and 2 or more features of the metabolic syndrome, in accord with the central role of type II skeletal muscle fibers in energy metabolism and obesity. CK was, however, independent of the PCOS phenotype.

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“…The excessive androgens from ovaries are considered as the most crucial inducer of PCOS [5] , although adrenal hyperandrogenism emerges in 20-30% PCOS women. [48] Statins are supposed to act primarily on the ovaries. First, statins had been con rmed not to take any effects on androgen levels in postmenopausal women, in whom it is wellknown that the major origin of androgens is extra-ovarian.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Statins on Hyperandrogenism In Women With Polycystic Ovary Syndrome: A Systematic Review And Meta-analysis of Randomized Controlled Trials

Chen

Huan

Zhang

et al. 2021

Preprint

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Several clinical studies showed that statins were potential to treat polycystic ovary syndrome (PCOS). Through comprehensive search PubMed, EMBASE, the Web of Science, BIOSIS, the ClinialTrails.gov, and the Cochrane Library database up to 14 Feb 2020, we identified the randomized controlled trials about the treatment of statins on hyperandrogenism in PCOS women, and performed a systematic review and meta-analysis. The quality of the included studies was assessed by the Cochrane risk of bias tool and the Jadda score. Subgroup analysis and sensitivity analysis were conducted to analyze the pooled results. Nine trials included 682 PCOS patients were identified. Statins showed a significant potential to reduce testosterone (SMD=-0.47; 95% CI, -0.76−-0.18; P = 0.002) and dehydroepiandrosterone (SMD=-0.51; 95% CI, -0.97−-0.05; P = 0.03) levels, compared to the control treatments. The cutaneous symptoms hirsutism (SMD=-0.61; 95% CI, -1.13−-0.10; P = 0.02) and acne (SMD=-0.92; 95% CI, -1.49−-0.34; P = 0.002) were significantly improved by statins in PCOS women. Subgroup analysis showed that the two types of statins, and the different control treatments as well, presented no significantly different effect on testosterone and dehydroepiandrosterone. Sensitivity analysis confirmed the stability of the findings from the meta-analysis. In conclusion, statin treatment could significantly reduce androgen levels and improve cutaneous manifestations of hyperandrogenism of PCOS.

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Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS

Cited by 23 publications

References 31 publications

The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome

The Associations between Sex Hormones and Lipid Profiles in Serum of Women with Different Phenotypes of Polycystic Ovary Syndrome

Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome

The Effects of Statins on Hyperandrogenism In Women With Polycystic Ovary Syndrome: A Systematic Review And Meta-analysis of Randomized Controlled Trials

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