Adrenal insufficiency due to recurrent renal cell carcinoma in the left adrenal gland 3 years after right radical nephrectomy for renal cell carcinoma

Lee, Myung-Won

doi:10.1080/00325481.2019.1696581

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…RCC is notorious for causing late metastasis. Contralateral adrenal metastasis has been reported in the literature as late as 23 years post-RCC diagnosis; among various RCC subtypes, most reports show clear cell histology [ 6 ]. Late contralateral adrenal metastasis recurrence following radical nephrectomy has only been documented in a handful of cases and is theorized to be due to one of the two primary reasons [ 7 ]: the slow growth of tumors in the case of low-grade tumors and loss to follow-up with regular surveillance imaging.…”

Section: Discussionmentioning

confidence: 99%

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Doodnauth

Waqar

Klar

et al. 2021

Cureus

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Responsible for 2% of global cancer diagnoses, renal cell carcinoma (RCC) can metastasize to almost every organ system; however, metastasis to the contralateral adrenal gland is extremely rare. We report the case of a 59-year-old male who presented with atypical chest pain and altered mental status. The patient developed hypotension, with hyponatremia raising concern for adrenal insufficiency (AI). We confirmed a diagnosis of AI secondary to adrenal metastasis in the setting of radical nephrectomy with ipsilateral adrenalectomy, and the patient’s symptoms resolved with adequate treatment. This report emphasizes the importance of complications caused by metastatic disease to the remaining adrenal gland in patients with RCC who have undergone ipsilateral radical nephrectomy.

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Section: Discussionmentioning

confidence: 99%

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Doodnauth

Waqar

Klar

et al. 2021

Cureus

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“…[136] The mechanisms of AGM-RCC include direct invasion, lymphovascular spread, and retrograde venous embolization. [137] The incidence of AGM-RCC is documented at 3% to 5% for ipsilateral adrenal gland metastasis from RCC, approximately 0.7% for contralateral adrenal gland metastasis from RCC, and a notably rare occurrence for bilateral adrenal gland metastasis from RCC (BAGM-RCC). [137] The determination of the most effective diagnostic strategy for adrenal tumors in patients with a history of RCC is still under debate.…”

Section: The Site Of Rcc Metastasismentioning

confidence: 99%

“…[137] The incidence of AGM-RCC is documented at 3% to 5% for ipsilateral adrenal gland metastasis from RCC, approximately 0.7% for contralateral adrenal gland metastasis from RCC, and a notably rare occurrence for bilateral adrenal gland metastasis from RCC (BAGM-RCC). [137] The determination of the most effective diagnostic strategy for adrenal tumors in patients with a history of RCC is still under debate. Contrast-enhanced CT scans are favored for diagnosing adrenal metastases, however, relying solely on radiological assessment may not suffice to distinguish between primary adrenal neoplasms, adrenocortical adenomas, and metastatic lesions in patients with RCC.…”

Section: The Site Of Rcc Metastasismentioning

confidence: 99%

Therapeutic options for different metastatic sites arising from renal cell carcinoma: A review

Wang,

Qian,

Qian

et al. 2024

Medicine

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Renal cell carcinoma (RCC) stands among the top 10 malignant neoplasms with the highest fatality rates. It exhibits pronounced heterogeneity and robust metastatic behavior. Patients with RCC may present with solitary or multiple metastatic lesions at various anatomical sites, and their prognoses are contingent upon the site of metastasis. When deliberating the optimal therapeutic approach for a patient, thorough evaluation of significant risk factors such as the feasibility of complete resection, the presence of oligometastases, and the patient’s functional and physical condition is imperative. Recognizing the nuanced differences in RCC metastasis to distinct organs proves advantageous in contemplating potential treatment modalities aimed at optimizing survival outcomes. Moreover, discerning the metastatic site holds promise for enhancing risk stratification in individuals with metastatic RCC. This review summarizes the recent data pertaining to the current status of different RCC metastatic sites and elucidates their role in informing clinical management strategies across diverse metastatic locales of RCC.

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Adrenal insufficiency due to recurrent renal cell carcinoma in the left adrenal gland 3 years after right radical nephrectomy for renal cell carcinoma

Cited by 2 publications

References 8 publications

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Metachronous Renal Cell Carcinoma: A Rare Presentation of Adrenal Crisis

Therapeutic options for different metastatic sites arising from renal cell carcinoma: A review

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