Adrenal masses differentiated by MR.

Reinig, J W; Doppman, John L.; Dwyer, Andrew J.; Johnson, Anna Rose; Knop, Richard H.

doi:10.1148/radiology.158.1.3940403

Cited by 171 publications

(31 citation statements)

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“…discovery of an adrenal mass without clinical manifestation has been increasing due to the development of imaging techniques such as ultrasonography (US), computed tomography (CT), and more recently, magnetic resonance imaging (MRI) [1][2][3][4][5][6][7][8][9][10][11]. These so-called "adrenal incidentalomas" are usually asymptomatic and often classified as non-functional tumors, but in recent years there have been several case reports of asymptomatic cortisol producing adrenal adenoma (ASCA) which secretes cortisol without clinical evidence of Cushing's syndrome, the so-called "Pre-Cushing's syndrome" or "Preclinical Cushing's syndrome" [12][13][14][15][16][17][18][19][20][21].…”

Section: Incidentalmentioning

confidence: 99%

Serum Levels of Dehydroepiandrosterone Sulfate in Patients with Asymptomatic Cortisol Producing Adrenal Adenoma: Comparison with Adrenal Cushing's Syndrome and Non-Functional Adrenal Tumor.

et al. 1996

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Abstract.The reported number of adrenal incidentalomas has been increasing because of wider application of imaging techniques. Patients with asymptomatic cortisol producing adrenal adenoma (ASCA) which secretes cortisol without clinical evidence of Cushing's syndrome has been more frequently observed than previously assumed, and they have a risk of adrenal insufficiency after adrenalectomy. Therefore patients with incidentalomas should be screened for cortisol overproduction. The aim of this study is to discover an easy screening test to uncover ASCA. We investigated the hormone profiles of 4 patients with ASCA in comparison with 11 patients with non-functional adrenal tumor and 10 patients with adrenal Cushing's syndrome.We also investigated the expression of dehydroepiandrosterone sulfotransferase (DHEA-ST) in surgically removed attached non-neoplastic adrenal tissues by immunostaining, which was considered to represent the degree of suppression of the hypothalamo-pituitary-adrenal axis. Serum dehydroepiandrosterone sulfate (DHEA-S) levels of all the patients with ASCA and adrenal Cushing's syndrome were lower than those of healthy subjects of corresponding age, but they were within the normal range in the patients with non-functional adrenal tumors. The serum DHEA-S level reflects the degree of suppression of the normal adrenal gland by cortisol hypersecretion from adrenal tumors. But the serum level of DHEA-S decreases with age, and because the normal range of serum DHEA-S is low in elderly subjects, we should be careful to evaluate the level of DHEA-S in elderly patients with adrenal Cushing's syndrome or ASCA. The immunohistochemical study showed DHEA-ST expression was noticeably suppressed in the adjacent adrenal cortex in ASCA and adrenal Cushing's syndrome. The decreased expression of DHEA-ST may reflect autonomous neoplastic cortisol secretion and subsequent ACTH suppression in ASCA and adrenal Cushing's syndrome.A single measurement of plasma ACTH or measurement of ACTH response to corticotropin-releasing hormone was not enough to screen for ASCA because of the wide variation among the cases. Dexamethasone suppression test is essential in identifying ASCA and also a single determination of serum DHEA-S is easy and may be useful for the screening of ASCA in adrenal incidentalomas in young and middle aged subjects, and is especially useful for outpatients.

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Section: Incidentalmentioning

confidence: 99%

Serum Levels of Dehydroepiandrosterone Sulfate in Patients with Asymptomatic Cortisol Producing Adrenal Adenoma: Comparison with Adrenal Cushing's Syndrome and Non-Functional Adrenal Tumor.

et al. 1996

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“…The group of proteolytic enzymes responsible for the degradation of ECM proteins and the basic membrane of blood vessels is MMP [14,15,16] . These enzymes participate in the development of some neoplasmatic diseases, like colon, breast, lung and adrenal gland cancers [17,18] , and some connective tissue diseases, including aortal aneurysm, Ehler-Danlos syndrome and Marfan's syndrome [19][20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Degradation of Collagen by Metalloproteinase 2 in Patients with Abdominal Hernias

Śmigielski

Kołomecki²,

Ziemniak³

et al. 2008

Eur Surg Res

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Background: The groin hernia is a significant social and economic problem of our times. The pathogenesis of the disease is not clear. The metalloproteinases (MMP) are the group of proteolytic enzymes responsible for the degradation of extracellular matrix proteins and the basic membrane of blood vessels. The aims of our study were: (1) to estimate the MMP-2 levels in the blood and tissues of patients with a groin hernia; (2) to answer the question of whether changes in MMP-2 activity correlate with the occurrence of inguinal hernias. Method: The study was performed on a group of 90 male patients suffering from inguinal hernias, aged 28–70 years (mean: 49 years). The control group was made up of 10 healthy (free from hernia) males, aged 30–68 years (mean: 46 years). Results: We noticed increased levels of MMP-2 in patients with all types of hernia and across all age groups. The MMP-2 mean serum levels were statistically higher in patients with a groin hernia when compared to the control group. The highest blood levels of MMP-2 were observed in young men with a direct hernia. Conclusions: This study confirmed the important role of MMP-2 in the pathogenesis of inguinal hernia. The increased activity may lead to dysfunctions in collagen fiber, which is responsible for forming fascial structures, and as a result weaken their durability.

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“…Indeed the current noninvasive methods have significant limitations for evaluating the mediastinum and potential extrathoracic metastases [3][4][5][6]. For example, about 60% of adrenal masses are of nonmetastatic origin and the false-positive rate in the case of bone scans can be up to 40% [7][8][9].…”

mentioning

confidence: 99%

Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer

Bury¹,

Dowlati²,

Paulus³

et al. 1997

Eur Respir J

141

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Whole-body 18 FDG positron emission tomography in the staging of non-small cell lung cancer. Th. Bury, A. Dowlati, P. Paulus, J.L. Corhay, R. Hustinx, B. Ghaye, M. Radermecker, P. Rigo. ERS Journals Ltd 1997. ABSTRACT: Despite advances in morphological imaging, some patients with lung cancer are found to have nonresectable disease at surgery or die of recurrence within yr of surgery.We performed a prospective study in 109 patients to compare the accuracy of whole-body positron emission tomography (PET) using fluorine-18 deoxyglucose ( 18 FDG) and conventional imaging (CI) methods for the staging of non-small cell lung cancer (NSCLC). When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or follow-up information.As compared to CI, 18 FDG-PET correctly changed the N stage in 22 patients (33%) and the M stage in 15 patients (14%). For the detection of distant metastases, PET study showed five false-positive sites and no false-negative cases. Currently, the accuracy of PET in the detection of M stage is 96%.Our study shows that visual interpretation of whole-body fluorine-18 deoxyglucose-positron emission tomography images can improve the diagnostic accuracy in the staging of non-small cell lung cancer. Further experience is needed to establish if metabolic imaging would be a cost-effective tool in the future management of lung cancer.

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Adrenal masses differentiated by MR.

Cited by 171 publications

References 0 publications

Serum Levels of Dehydroepiandrosterone Sulfate in Patients with Asymptomatic Cortisol Producing Adrenal Adenoma: Comparison with Adrenal Cushing's Syndrome and Non-Functional Adrenal Tumor.

Serum Levels of Dehydroepiandrosterone Sulfate in Patients with Asymptomatic Cortisol Producing Adrenal Adenoma: Comparison with Adrenal Cushing's Syndrome and Non-Functional Adrenal Tumor.

Degradation of Collagen by Metalloproteinase 2 in Patients with Abdominal Hernias

Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer

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