Adrenal morphometry in unilateral and sham adrenalectomized syracuse high and low avoidance rats

Paine, Stephanie N. Del; Brush, F. Robert

doi:10.1016/0031-9384(90)90317-w

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Similar results were observed after exogenous CRH administration [148]. Quite surprisingly, reduced adrenal corticosterone levels occur despite greater relative adrenal weight and greater size of adrenal cortex in SLA rats [148,149]. The most likely explanation is that RLA showed a defective adrenocortical responsiveness to ACTH that tended to be compensated by increased adrenal mass.…”

Section: Selection On the Basis Of Active Avoidance Performancesupporting

confidence: 68%

Searching for Biological Markers of Personality: Are There Neuroendocrine Markers of Anxiety?

Armario¹,

Nadal²

2013

New Insights Into Anxiety Disorders

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Section: Selection On the Basis Of Active Avoidance Performancesupporting

confidence: 68%

Searching for Biological Markers of Personality: Are There Neuroendocrine Markers of Anxiety?

Armario¹,

Nadal²

2013

New Insights Into Anxiety Disorders

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“…This is of particular interest because previous studies have shown that the Brush Syracuse Low-Avoidance rats are more sensitive to chlordiazepoxide than the Syracuse High-Avoidance rats, and substantial evidence suggests that the Syracuse Low-Avoidance rats are more emotionally reactive than the Syracuse High-Avoidance rats in a variety of tasks including novelty stress, conditioned suppression, and active and passive avoidance learning (Brush et al, 1988;Flaherty & Rowan, 1989). Furthermore, the Syracuse Low-Avoidance rats have enlarged adrenal glands but have reduced corticosterone secretion compared with the Syracuse High-Avoidance rats (Brush, 1992;Brush, Isaacson, Pellegrino, Rykaszewski, & Shain, 1991;Del Paine & Brush, 1990). Thus, the previous finding from our laboratory that the Syracuse Low-Avoidance rats showed larger successive negative contrast effects than the Syracuse High-Avoidance rats, and that chlordiazepoxide was effective only in the Syracuse Low-Avoidance rats, suggested that more emotional rats show larger contrast effects and that the benzodiazepines are particularly effective in these rats.…”

Section: Discussionmentioning

confidence: 99%

Selective breeding for negative contrast in consummatory behavior.

Flaherty¹,

Krauss²,

Rowan-Szal³

et al. 1994

Journal of Experimental Psychology: Animal Behavior Processes

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Rats showing either large or small reductions in licking following a shift from 32% to 4% sucrose were selectively bred for 7 generations. Rats from the 2 resulting lines reliably differed in successive negative contrast and in activity (radial-arm maze and open field). Differences in activity and contrast were not correlated. Heritability (h2) of the reaction to sucrose shift was reliable in the last 6 filial generations and equaled 0.64 in the F7 generation. The 2 lines did not differ (a) in response to the absolute rewarding value of sucrose or cocaine; (b) in open-field defecations or thigmotaxis; (c) in anticipatory contrast; or (d) in responsivity to midazolam. Responsivity to reward reduction may involve a relatively delimited psychological process that is amenable to selection.

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“…Syracuse high and low avoidance (SHA, SLA) rats originated from Long-Evans rats and differ not only in TWAA, but also in other behaviors: SLA showed normal open-field activity, improved passive avoidance and greater conditioned emotional response [ 81 - 83 ]. SLA showed higher adrenal weight and adrenal cortex and medulla size [ 84 - 86 ]. In both sexes, SLA showed higher adrenal and probably higher basal corticosterone levels but a similar response to ether exposure (although adrenal content was higher in SHA) [ 85 , 83 ].…”

Section: Hpa Activity In Strains or Lines Differing In Emotionality A...mentioning

confidence: 99%

Differential Hypothalamic-pituitary-adrenal Response to Stress among Rat Strains: Methodological Considerations and Relevance for Neuropsychiatric Research

Armario

Belda

Gagliano

et al. 2023

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The hormones of the hypothalamic-pituitary-adrenal (HPA) axis, particularly glucocorticoids (GCs), play a critical role in the behavioral and physiological consequences of exposure to stress. For this reason, numerous studies have described differences in HPA function between different rodent strains/lines obtained by genetic selection of certain characteristics not directly related to the HPA axis. These studies have demonstrated a complex and poorly understood relationship between HPA function and certain relevant behavioral characteristics. The present review first remarks important methodological considerations regarding the evaluation and interpretation of resting and stress levels of HPA hormones. Then, it presents works in which differences in HPA function between Lewis and Fischer rats were explored as a model for how to approach other strain comparisons. After that, differences in the HPA axis between classical strain pairs (e.g. High and Low anxiety rats, Roman high- and low-avoidance, Wistar Kyoto versus Spontaneously Hypertensive or other strains, Flinder Sensitive and Flinder Resistant lines) are described. Finally, after discussing the relationship between HPA differences and relevant behavioral traits (anxiety-like and depression-like behavior and coping style), an example for main methodological and interpretative concerns and how to test strain differences is offered.

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Adrenal morphometry in unilateral and sham adrenalectomized syracuse high and low avoidance rats

Cited by 7 publications

References 20 publications

Searching for Biological Markers of Personality: Are There Neuroendocrine Markers of Anxiety?

Searching for Biological Markers of Personality: Are There Neuroendocrine Markers of Anxiety?

Selective breeding for negative contrast in consummatory behavior.

Differential Hypothalamic-pituitary-adrenal Response to Stress among Rat Strains: Methodological Considerations and Relevance for Neuropsychiatric Research

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