Adrenal myelolipoma: Clinical, radiologic, and histologic features

Dieckmann, Klaus‐Peter; Hamm, Bernd; Pickartz, H; Jonas, Dietger; Bauer, H. W.

doi:10.1016/0090-4295(87)90587-5

Cited by 69 publications

(49 citation statements)

References 57 publications

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“…It has been recommended that surgery should be reserved only for symptomatic tumours as well as asymptomatic large tumours more than 4 cm in size, as found in our patient. These large tumours are associated with a higher risk for retroperitoneal haemorrhage (1,2,9). Small tumours can be monitored clinically with periodic ultrasound or CT examination (1,9).…”

Section: Discussionmentioning

confidence: 99%

“…These large tumours are associated with a higher risk for retroperitoneal haemorrhage (1,2,9). Small tumours can be monitored clinically with periodic ultrasound or CT examination (1,9).…”

Section: Discussionmentioning

confidence: 99%

“…They are very rare, with an incidence rate of between 0.08 to 0.20% at autopsy (1), and are usually hormonally inactive (1,2). Often clinically silent, most cases are discovered at autopsy.…”

Section: Introductionmentioning

confidence: 99%

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The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis

Li-Fern

Rajasoorya²

1999

European Journal of Endocrinology

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A 39-year-old Chinese man with hypertension being evaluated for elevated serum alkaline phosphatase (SAP) levels was found to have an incidental right adrenal mass. The radiological features were characteristic of a large adrenal myelolipoma. This mass was resected and the diagnosis confirmed pathologically. His blood pressure normalised after removal of the myelolipoma, suggesting that the frequently observed association between myelolipomas and hypertension may not be entirely coincidental. Persistent elevation of the SAP levels and the discovery of hypercalcaemia after surgery led to further investigations which confirmed primary hyperparathyroidism due to a parathyroid adenoma. The patient's serum biochemistry normalised after removal of the adenoma.The association of adrenal myelolipoma with primary hyperparathyroidism has been reported in the literature only once previously. Although unconfirmed by genetic studies this association may possibly represent an unusual variation of the multiple endocrine neoplasia type 1 syndrome.

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Section: Discussionmentioning

confidence: 99%

“…These large tumours are associated with a higher risk for retroperitoneal haemorrhage (1,2,9). Small tumours can be monitored clinically with periodic ultrasound or CT examination (1,9).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis

Li-Fern

Rajasoorya²

1999

European Journal of Endocrinology

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“…A large number of theories have been proposed, including: ectopia of myeloid tissue, embolism of bone marrow elements, hamartosis, metaplasia, degeneration of cortical cells and haematopoietic proliferation of substances formed by tumour necrosis. 33 Some researchers 14 hypothesised that the association of adrenalcortical adenoma and myelolipoma in Conn's syndrome may be entirely coincidental and that corticotropin stimulation (since aldosterone-producing adenomas are partially corticotropin-dependent) may be involved in the pathogenesis of myelolipoma. This pathogenetic hypothesis is, in part, supported by experimental studies by Seyle and Stone, 34 who reported that crude anterior pituitary extracts, rich in corticotropin, caused marked myelopoiesis when injected into the adrenal cortex of rats.…”

Section: Discussionmentioning

confidence: 99%

A rare combination consisting of aldosterone-producing adenoma and adrenal myelolipoma in a patient with heterozygosity for retinoblastoma (RB) gene

Caliumi

Toma

Bossini

et al. 2004

J Renin Angiotensin Aldosterone Syst

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Various pathological disorders have been associated with primary aldosteronism, including glucagonoma, phaeochromocytoma and primary hyperparathyroidism.In this report, a case of adrenal myelolipoma (a rare non-functioning tumour composed of mature adipose tissue and normal haematopoietic elements similar to bone marrow cells), aldosterone-producing adenoma and a pituitary microadenoma coexisting in a 62-year-old man with a 15-year history of arterial hypertension, previous ablation of an autonomouslyfunctioning thyroid adenoma, multiple lipomas and an heterozygosity of the retinoblastoma (RB) susceptibility gene is reported.We believe that this case probably represents another variant of the multiple neoplasia syndrome and we speculate that structural alteration of the RB gene may play a role in the tumorogenesis.

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“…Pathologically, ALTs include myelolipoma, lipoma, angiomyolipoma, teratoma and liposarcoma. 6,[11][12][13] In this study, we retrospectively reviewed the features of 73 cases of ALT treated at a single centre over a 31-year period. This is by far the largest series of ALTs reported to date.…”

Section: Introductionmentioning

confidence: 99%

The diagnosis and treatment of primary adrenal lipomatous tumors in Chinese patients: a 31-year follow-up study

Zhao

Sun

Xie

et al. 2014

CUAJ

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Results: A total of 73 cases of primary ALTs in 22 men and 51 women (mean age 51.1±14.2 years) were reviewed. The ALTs included 65 myelolipomas (89.0%), 3 lipomas (4.1%), 2 angiomyolipomas (2.7%), 2 teratomas (2.7%), and 1 liposarcoma (1.4%). Of the total 73 patients, 24 of them had tumours in the left adrenal gland, 47 in the right gland and 2 had bilateral tumours. In total, 51 patients underwent open surgery and 22 laparoscopic surgery. Conclusion: Myelolipoma is predominant among the various types of lipomatous adrenal gland tumours; it accounts for about 90% of all cases. Surgery is recommended for tumours ≥3.5 cm in diameter, for all cases of symptomatic tumour, and for cases of teratoma or liposarcoma identified by preoperative imaging.

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Adrenal myelolipoma: Clinical, radiologic, and histologic features

Cited by 69 publications

References 57 publications

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis

A rare combination consisting of aldosterone-producing adenoma and adrenal myelolipoma in a patient with heterozygosity for retinoblastoma (RB) gene

The diagnosis and treatment of primary adrenal lipomatous tumors in Chinese patients: a 31-year follow-up study

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