Adrenal Pheochromocytoma Mimicking Small Cell Carcinoma on Fine Needle Aspiration Biopsy

Deodhare, Sanjeev; Chalvardjian, Ara; Lata, Andrew; Marcuzzi, Danny

doi:10.1159/000334034

Cited by 14 publications

(6 citation statements)

References 3 publications

(4 reference statements)

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“…Phaeochromocytoma can be an unexpected finding in adrenal aspirates and its cytological features have been recently examined 21 . Although the literature includes a case of phaeochromocytoma mimicking small cell carcinoma 22 , we did not observe any case with this differential diagnosis in our series. In the absence of morphological features of malignancy, it is only the presence of metastases that can be considered certain evidence of a malignant neoplasm.…”

Section: Discussionmentioning

confidence: 55%

Fine needle aspiration cytology (FNAC) of adrenal masses

2000

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Between 1992 and 1998 at the Pathology Section, Cytopathology Unit of the Department of Oncological and Surgical Sciences of the University of Padova, we performed one hundred and twelve FNACs of adrenal masses under radiological guidance and seven intraoperative scrape smears; histological follow-up was available in 55 cases. Immediate on-site assessment of smears revealed a satisfactory adequacy rate (92%). With a simple diagnostic tree, we have been able to classify all smears except one as benign or malignant correctly, (accuracy 97.6%), differentiation of primary tumours from metastatic depositions remaining the most difficult task. In our experience FNAC is a safe and accurate tool in the diagnostic characterization of adrenal masses.

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Section: Discussionmentioning

confidence: 55%

Fine needle aspiration cytology (FNAC) of adrenal masses

2000

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“…One case of adrenal pheochromocytoma was interpreted as small-cell carcinoma in both TP and CP (reported elsewhere). 9 Two cases showed a positive cytology in both TP and CP, but the surgical biopsies were negative. One of them was the FNA of a small-cell carcinoma of the lung.…”

Section: Comparison Of the Cytologic Features Between Tp And Cp Is Shmentioning

confidence: 93%

Comparison of ThinPrep and conventional preparations: Nongynecologic cytology evaluation

1997

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ThinPrep processing, an automated cytopreparatory method, has been reported to show good correlation with conventional preparations and to reduce the rate of false‐negative diagnoses. In a retrospective review of 230 consecutive nongynecologic cytology cases, we compare the ThinPrep (TP) method with conventional preparations (CP). There were 129 fine‐needle aspiration (FNA) specimens from various sites, including 51 breasts, 40 thyroids, 14 lungs, 8 livers, and 16 miscellaneous sites. The sources of 101 body cavity fluids included 68 pleural peritoneal effusions, 25 peritoneal pelvic washings, and 8 miscellaneous sites. Each case was evaluated for cellularity, morphologic details, and obscuring background material. Diagnoses of the TP slides were classified as insufficient, normal, benign, suspicious, or malignant. Each case was then correlated with the tissue diagnosis when available. In TP slides, cellular arrangements, nuclear details, and nuclear cytoplasmic ratio were preserved, while blood and diathesis were eliminated. There was no statistically significant difference between TP and CP in the diagnostic categories. However, in six cases of “insufficient for diagnosis” on FNA by CP. TP yielded sufficient cells and tissue fragments for diagnosis. One case each of FNA and body fluid with a diagnosis of “suspicious for malignancy” by CP was considered “positive” on TP slides. The overall sensitivity of TP was 97.6%, and the specificity was 92.9%. The positive predictive value was 93.0%. We conclude that the ThinPrep method shows good correlation with conventional preparations in both FNA and body fluids. Diagn. Cytopathol. 16:368–371, 1997. © 1997 Wiley‐Liss, Inc.

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“…In this report, urine cytology of a PBPG case was described, which has not been previously published. Aspiration cytology has been reported, but urinary cytologic descriptions were not included. Cytopathologic findings of aspiration smears varied in cellularity from scant to hypercellular in a hemorrhagic background .…”

Section: Discussionmentioning

confidence: 99%

“…Primary bladder paraganglioma (PBPG) is very rare, comprising <0.05% of all bladder tumors . The aspiration cytologic features of pheochromocytomas or paragangliomas have been described in different sites, including adrenal gland, thyroid, carotid body, peripancreatic area, and parapharyngeal area . However, the cytologic features of PBPG on urine cytology have not been described.…”

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confidence: 99%

Urine cytology findings of primary paraganglioma of the urinary bladder: Case report

Lee

Park

Cho

et al. 2017

Diagnostic Cytopathology

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Paraganglioma (PG) of the urinary bladder was detected in a 64-year-old male who was admitted to the hospital with gross hematuria. In voided urine, atypical cells were scattered as nests and single cells on low-power view. On higher-power view, tumor nests were composed of epithelioid cells with fine chromatin and moderate cytoplasm admixed with occasional spindle sustentacular cells. Single cells were discohesive and large with moderate cytoplasm and inconspicuous nucleoli. Subsequent cystoscopy revealed a solid oval mass. Histologically, tumor from the resected bladder showed infiltrating nested tumor cells with abundant cytoplasm. Immunohistochemically, the tumor cells were positive for synaptophysin, chromogranin, and CD56. The patient underwent partial cystectomy and was discharged without complications. Diagn. Cytopathol. 2017;45:350-353. © 2016 Wiley Periodicals, Inc.

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Adrenal Pheochromocytoma Mimicking Small Cell Carcinoma on Fine Needle Aspiration Biopsy

Cited by 14 publications

References 3 publications

Fine needle aspiration cytology (FNAC) of adrenal masses

Fine needle aspiration cytology (FNAC) of adrenal masses

Comparison of ThinPrep and conventional preparations: Nongynecologic cytology evaluation

Urine cytology findings of primary paraganglioma of the urinary bladder: Case report

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