Adrenal relationships to aggressiveness in isolated female mice

Schwartz, R.; Sackler, Arthur M.; Weltman, Arthur

doi:10.1007/bf01927733

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…According to Ramirez et al (1980), excitement or irritation, states related to inner tension, cause aggressive behavior. In some studies it is suggested that isolated housing is stressful for mice (Schwartz et al 1974;Weltman et al 1968;Valzelli 1973) and causes such increased inner tension, whereas other studies suggested that it does not (Goldsmith et al 1976(Goldsmith et al , 1978bBrain 1975;Stanislaw & Brain 1983;Anton et al 1968). In these latter studies it was found that the isolated mice were not in a stressful condition when adrenal function was used as an index, and it was suggested that the isolated mice were territorial dominants.…”

Section: Discussionmentioning

confidence: 92%

“…Several explanations have been proposed: the "escalation hypothesis" from the behavioral aspect (Cairns & Scholz 1973), an explanation considering endocrinal changes caused by isolation stress (Baer 1971;ValzeUi 1973;Schwartz, Sackler & Weltman 1974), and a view that sees isolated mice as dominant and territorial (Brain 1975). Fox (1986) described an "isolation-emergence syndrome" (the behavior patterns characteristic to the animals when they were returned to social groups from isolated housing conditions) in dogs as (1) fear response, (2) hyperexploratory behavior, and (3) impaired pain perception.…”

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confidence: 99%

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Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Koyama¹

1993

J. Ethol.

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--In previous studies, isolated mice are found to be extremely more aggressive than group-reared mice. In most of those studies, however, the pairings of the groupreared mice were randomly determined, without attention to individuals' ranks in their home cages. In this study, the effect of isolation was analyzed by comparing isolated mice with dominants of group-reared mice. In experiment 1 the group-reared mice were randomly chosen as in previous studies. Isolated mice were significantly more aggressive, but the pairings of the group-reared mice were found to be all dominant vs. subordinate. In experiment 2, the group-reared dominants encountered unfamiliar dominants in an unfamiliar place. Dominant mice were found to be less aggressive than the isolated mice. This result was inconsistent with the "territorial dominant hypothesis" on the hyperaggressiveness of the isolated mice. Sequential analysis of behavior clarified that the isolated mice had a sequential pattern quite different from the group-reared mice, and provided an illustrative figure for the "escalation hypothesis". The lack of aggression in the group-reared mice, however, left a question about the sequence similarity of aggressive behavior in isolated and group-reared mice.

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Koyama¹

1993

J. Ethol.

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“…Sigg (1 969) refers to elevated adrenocortical activity whereas Welch and Welch (1969), in the same symposium, described the lowered activity of this gland in individually housed mice. In this respect, it is often difficult to interpret data of workers -e.g., Schwartz et al, 1974 -who followed the same batch of mice throughout many weeks, subjecting the mice to numerous, presumably stressful behavioral tests and sampling techniques, and then ascribed the elevated adrenocortical activities to isolation per se.…”

Section: Introductionmentioning

confidence: 99%

Effects of age at differential housing and the duration of individual housing/grouping on lntermale fighting behavior and adrenocortical activity in TO strain mice

1976

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“…However, laboratory studies have failed to reveal a consistent relationship between housing density and pituitary-adrenal function in female mice (Schwartz, Sackler & Weltman, 1974;Brain, 1975;Goldsmith, Brain & Benton, 1977;Nichols & Chevins, 1981a). One variable that has been ignored in these studies is the presence of a male or males.…”

Section: Introductionmentioning

confidence: 91%

Adrenocortical Responses and Changes During the Oestrous Cycle in Mice: Effects of Male Presence, Male Urine and Housing Conditions

Nichols¹,

Chevins²

1981

Journal of Endocrinology

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Male urine applied daily to their bedding raised the basal levels of plasma corticosterone in individually housed, virgin female mice, when compared with females (grouped or individually housed) living with male mice or with group-housed females exposed daily to male urine. Values were not affected during ether-induced stress. A single application of male urine raised plasma levels 30 min later regardless of housing conditions; but after 4 and 24 h levels had fallen to normal. The results are discussed in terms of sensitization of the pituitary-adrenal system and of stress and reproductive pheromones. Male urine was less effective than male presence at inducing 4-day oestrous cycles. Length and type of cycle varied continuously under the influence of a spectrum of environmental signals.

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Adrenal relationships to aggressiveness in isolated female mice

Cited by 11 publications

References 14 publications

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Isolation effect in mice (Mus musculus): (i) Does it really induce aggression?

Effects of age at differential housing and the duration of individual housing/grouping on lntermale fighting behavior and adrenocortical activity in TO strain mice

Adrenocortical Responses and Changes During the Oestrous Cycle in Mice: Effects of Male Presence, Male Urine and Housing Conditions

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