2014
DOI: 10.1007/s00213-014-3590-6
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Adrenal steroid hormones and ethanol self-administration in male rhesus macaques

Abstract: Rationale Hypothalamic-pituitary-adrenal (HPA) axis hormones have neuroactive metabolites with receptor activity similar to ethanol. Objectives The present study related HPA hormones in naïve monkeys to ethanol self-administration. Methods Morning plasma adrenocorticotropic hormone (ACTH), cortisol, deoxycorticosterone (DOC), aldosterone and dehydroepiandrosterone-sulfate (DHEA-S) were measured longitudinally in male rhesus macaques (Macaca mulatta) induced to drink ethanol followed by access to ethanol (4… Show more

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Cited by 20 publications
(29 citation statements)
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“…Furthermore, alcohol may act as an endocrine disruptor by altering levels of and/or skeletal response to vitamin D, sex hormones (e.g., estrogen and testosterone), parathyroid hormone, pituitary-derived hormones (e.g., growth hormone), and adipocyte-derived hormones (e.g., leptin) [24, 25]. Alcohol self-administration lowered dehydroepiandrosterone-sulfate and selectively altered its adrenocortical regulation in rhesus macaques but did not lower testosterone levels [73]. Low 25-hydroxyvitamin D levels, due to poor nutritional status, are often found in chronic alcohol consumers [46, 47].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, alcohol may act as an endocrine disruptor by altering levels of and/or skeletal response to vitamin D, sex hormones (e.g., estrogen and testosterone), parathyroid hormone, pituitary-derived hormones (e.g., growth hormone), and adipocyte-derived hormones (e.g., leptin) [24, 25]. Alcohol self-administration lowered dehydroepiandrosterone-sulfate and selectively altered its adrenocortical regulation in rhesus macaques but did not lower testosterone levels [73]. Low 25-hydroxyvitamin D levels, due to poor nutritional status, are often found in chronic alcohol consumers [46, 47].…”
Section: Discussionmentioning
confidence: 99%
“…We have also observed the same relationship between age and heavy alcohol intake in female rhesus macaques (unpublished observation). Of the HPA-related hormones studied in the late adolescent/young adult male monkeys (ACTH, cortisol, deoxycorticosterone (DOC), DHEA-S, and aldosterone) the neurosteroid DOC at baseline was uniquely predictive of attaining high BECs during open-access self-administration (Helms et al, 2014b). Thus, both the young adult stage and circulating DOC appear related to risk for heavy drinking, although these factors cannot be disentangled with the current datasets.…”
Section: Ii: Assessment Of Risks For Heavy Drinking and Stress Interamentioning
confidence: 99%
“…In this context, there is not a general lack of ACTH sensitivity at the adrenal gland, as hormones from each layer of the adrenal cortex were not uniformly desensitized. Specifically, male rhesus macaques have significantly lower basal ACTH following long-term daily alcohol self-administration while the adrenal steroids are differentially affected (Helms et al, 2014b). Cortisol (secreted from the zona fasciculata) remained constant across the experimental phases, similar to sulfated dehydroepiandrosterone (DHEA-S, an androgen secreted from the zona reticularis).…”
Section: Iii: Consequences Of Heavy Drinking On Stress Systemsmentioning
confidence: 99%
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“…Finally, in order to explore whether the putative moderator effect of BP may also relate to peripheral neuroendocrine biomarkers, we also assessed blood levels of cortisol and aldosterone. In fact, both hormones may play a role in BP tone (Lyngso et al, 2016; Ullian, 1999), as well as in excessive alcohol drinking (Helms et al, 2014; Leggio et al, 2008; Spencer and Hutchison, 1999). …”
Section: Introductionmentioning
confidence: 99%