Adrenaline-Induced Pulmonary Oedema and Its Treatment. A Report of Two Cases

Optimal Concentration of Epinephrine for Vasoconstriction in Ear Surgery

“… 7 Pulmonary edema develops secondary to epinephrine causing increased peripheral vascular resistance and tachycardia leading to decreased diastolic filling time, cardiac failure, and subsequent increased pulmonary circulation pressure. 8 Certain inhaled anesthetics, specifically halogenated hydrocarbons like halothane, sensitize myocardium to epinephrine, increasing the chance for complication. 9 …”

Adrenaline‐induced acute massive pulmonary oedema in the dog

“…Lung oedema occurred in man after accidental injection of a large dose of adrenaline (Ersoz & Finestone, 1971), and a large dose of adrenaline consistently induced acute massive oedema in the rat, rabbit and other small laboratory animals (Cheng, 1958;Worthen, Placik, Argano, MacCanon & Luisada, 1969). The haemodynamic changes of adrenaline-induced lung oedema have been little studied because of the exceptional difficulty in producing the condition in large experimental animals such as the dog (Jordan & DeLaney, 1951;Saitoh, Kinoshita, Tokumasa, Nakamura, Usami & Doba, 1967).…”

Does the administration of the calcium-antagonist verapamil in tocolysis with beta-sympathicomimetics still make sense?

“…The reason for this is the rapid biotransformation of the active substance Verapamil into ineffective or only weakly effective metabolites [34], Our own studies [38] have revealed that the average serum concentration of the mother after administration of Verapamil at a dosage rate of 2 Mg/kg/min was 19.3 ± 3 ng/ml. Since fluid displacements in the lungs up to the severity of manifest pulmonary edema after administration of adrenergics is due at least in part to hemodynamic factors [3,10,36], it comes äs no surprise that the administration of Verapamil has no influence on the fluid displacement from the intravascular to the extravascular space induced by Fenoterol.…”