Adrenaline induces calcium signal in astrocytes and vasoconstriction via activation of monoamine oxidase

Novikova, Irina N.; Manole, Andreea; Zherebtsov, Evgeny; Stavtsev, D. D.; Vukolova, Marina N.; Dunaev, Andrey V.; Angelova, Plamena R.; Abramov, Andrey Y.

doi:10.1016/j.freeradbiomed.2020.07.011

Cited by 29 publications

(14 citation statements)

References 28 publications

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“…Effects of inhibitors of MAO on SSCO of neurons under exposure of dopamine can be explained by effective inhibition of the calcium signal in astrocytes [10,18]. Inhibition of SSCO in neurons under application of bifemelane by itself can be explained by decrease of production of ROS in MAO of neurons and reduction of activity of phospholipase C [40].…”

Section: Discussionmentioning

confidence: 99%

“…Considering multiple effects of dopamine on signals of neurons and astrocytes we can suggest that neurons and astrocytes could affect to each other using this monoamine. Dopamine and other catecholamines including tyramine and adrenaline can activate calcium signal astrocytes via production of hydrogen peroxide in MAO that lead to redox changes and stimulation of phospholipase C [10,18,19]. However, activation of dopamine receptors also could have an effect on calcium signalling in astrocytes.…”

Section: Introductionmentioning

confidence: 99%

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Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal

et al. 2021

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“…After isolation, the rat brain was placed in chilled Hanks' Balanced Salt solution (HBSS). Horizontal sections of different brain regions (hippocampus, cortex, cerebellum, brain stem) with a thickness of 500 μm were cut—according to the standard procedures (Angelova & Muller, 2006; Novikova et al., 2020) and stored prior to experiments for at least 1 hr/37°C.…”

Section: Methodsmentioning

confidence: 99%

Variability of mitochondrial energy balance across brain regions

Cheng

Vinokurov

Zherebtsov

et al. 2020

Journal of Neurochemistry

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Despite the fact that the brain is relatively small compared to the rest of the body (1%-1.5%), is one of the most energy-consuming organs and utilizes more oxygen and glucose than any other tissue. The major energy demands of the brain are because of neuronal signaling (~70% is used for calcium signalling, action and resting potentials, glutamate cycling) and the remaining 30% of the energy expenses is associated with non-signaling activities (de novo synthesis of proteins, phospholipids, oligonucleotide turnover, axonal transport, actin cytoskeleton remodelling, etc.) (Dienel, 2019). Importantly, the rate of information processing in the brain is also limited by efficient energy production (Attwell & Laughlin, 2001;Harris et al., 2012).Because of the tight equilibrium between energy production and consumption, the brain is extremely vulnerable to any alterations of this balance, as occurs for example in an ischemic condition.

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“…After extraction, the mice brains were placed in chilled HBSS. Transverse sections of midbrain with a thickness of 100 lm were cut, according to standard procedures [40,41] and stored prior to experiments for at least 1 h/37 °C.…”

Section: Acute Brain Slicesmentioning

confidence: 99%

Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease

et al. 2021

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Parkinson's disease (PD) is a progressive neurodegenerative disorder induced by the loss of dopaminergic neurons in midbrain. The mechanism of neurodegeneration is associated with aggregation of misfolded proteins, oxidative stress, and mitochondrial dysfunction. Considering this, the process of removal of unwanted organelles or proteins by autophagy is vitally important in neurons, and activation of these processes could be protective in PD. Short-time acidification of the cytosol can activate mitophagy and autophagy. Here, we used sodium pyruvate and sodium lactate to induce changes in intracellular pH in human fibroblasts with PD mutations (Pink1, Pink1/Park2, a-synuclein triplication, A53T). We have found that both lactate and pyruvate in millimolar concentrations can induce a shorttime acidification of the cytosol in these cells. This induced activation of mitophagy and autophagy in control and PD fibroblasts and protected against cell death. Importantly, application of lactate to acute brain slices of WT and Pink1 KO mice also induced a reduction of pH in neurons and astrocytes that increased the level of mitophagy. Thus, acidification of the cytosol by compounds, which play an important role in cell metabolism, can also activate mitophagy and autophagy and protect cells in the familial form of PD.

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Adrenaline induces calcium signal in astrocytes and vasoconstriction via activation of monoamine oxidase

Cited by 29 publications

References 28 publications

Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal

Dopamine controls neuronal spontaneous calcium oscillations via astrocytic signal

Variability of mitochondrial energy balance across brain regions

Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease

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