Adrenergic and Dopaminergic Response to Chronic Chair Restraint in the Rhesus Monkey

Perlow, Mark J.; Karoum, Farouk; Braun, Delores; Wyatt, Richard Jed

doi:10.1097/00006842-197903000-00007

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…This is among the first reports of a relationship between plasma catecholamine levels and social behavior in an anesthetized subject of any species. Anesthetization obviates the need to maintain an indwelling catheter in an animal chronically restrained outside its accustomed social milieu (19,26) and reduces the impact of poorly controlled exogenous factors tending to influence catecholamine levels. In future studies, an anesthetic, and/or a procedure having less effect on sympathetic function (2) might be employed.…”

Section: Discussionmentioning

confidence: 99%

Plasma catecholamines and social behavior in male vervet monkeys (Cercopithecus aethiops sabaeus)

Dillon

Raleigh²,

McGuire³

et al. 1992

Physiology & Behavior

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Many investigations in humans indicate that epinephrine, norepinephrine and their ratio may correlate with such traits as social competence, academic achievement, and aggression. However, the socioeconomic, dietary, and environmental confounds accompanying most human studies complicate their interpretation. Social status, aggression, and other social behaviors can be reliably assessed in nonhuman primates under conditions controlling for crucial environmental factors. If interpretation of human studies is correct, dominant and subordinate male vervet monkeys should exhibit distinctive patterns of catecholamine secretion. To test this possibility, seventeen adult male monkeys living in six stable social groups were observed for 6 months. Based on their success in agonistic events, subjects were categorized as dominant or subordinate. Alpha scores were calculated from empirically derived factors to provide a noncategorical measure of dominant behavioral style. Plasma epinephrine and norepinephrine samples obtained from anesthetized subjects did not differ between dominant and subordinate males. Alpha scores, however, distinguished high from low norepinephrine/epinephrine ratio groups. These findings are consistent with studies in humans linking high epinephrine, low norepinephrine, and social competence.

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Section: Discussionmentioning

confidence: 99%

Plasma catecholamines and social behavior in male vervet monkeys (Cercopithecus aethiops sabaeus)

Dillon

Raleigh²,

McGuire³

et al. 1992

Physiology & Behavior

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“…In these latter analyses, 0.1 ml of urine was mixed into 1 ml 1 N HCI containing 100 ng of deuterated isomers of each of the metabolites. The metabolites were extracted into ethylacetate and then derivatized to their methylester/pentafluoropropionate derivatives (Karoum et al, 1975a;Perlow et al, 1979). p-Tyramine was measured directly by mixing 10 pl of urine in 20 p1l of a solution containing 25 ng of deuterated p-tyramine ([2H4]-tyramine).…”

Section: Methodsmentioning

confidence: 99%

A Study on the Acute Effect of Amphetamine on the Urinary Excretion of Biogenic Amines and Metabolites in Monkeys

Chuang

Karoum

Perlow

1981

British J Pharmacology

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1 The effects of an acute dose (3 mg/kg) of amphetamine on the urinary excretion of phenylethylamine (PEA), p-tyramine, their metabolites, catecholamine metabolites and phydroxymandelic acid, a major metabolite of p-octopamine were evaluated in the monkey. Amphetamine excretion was also measured. 2 Amphetamine was slowly eliminated from the body, being found in the urine at least six days after administration. 3 Amphetamine increased the excretion of PEA and decreased that of its major metabolite, phenylacetic acid (PAA). This pattern of changes is similar to that previously found in the urine of chronic schizophrenics. 4 The excretion of the dopamine metabolite, 3,4-dihydroxphenylacetic acid (DOPAC) was markedly reduced, that of vanilmandelic acid (VMA) remained unchanged while 3-methoxy-4-hydroxyphenylglycol (MHPG) was increased on the day of drug administration and persisted for at least a further six days. A similar extended effect on the excretion of p-hydroxymandelic acid (it was reduced) was also observed. 5 The excretion of p-tyramine but not its metabolite, p-hydroxyphenylacetic acid, was decreased by amphetamine during treatment and returned to normal levels six days later. 6 From the results obtained, it was concluded that amphetamine effects on behaviour cannot exclusively be attributed to its influence on catecholamines and that other biogenic amines may be involved.7 Since PEA elicits many behavioural changes similar to those seen with amphetamine, and since amphetamine increases PEA excretion, we suggest that amphetamine may exert some of its behavioural responses through the release of PEA.

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Further evidence for the role of the caudate nucleus in programming motor and nonmotor behavior in Java monkeys

Vries¹,

Cools²

1985

Experimental Neurology

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Adrenergic and Dopaminergic Response to Chronic Chair Restraint in the Rhesus Monkey

Cited by 6 publications

References 21 publications

Plasma catecholamines and social behavior in male vervet monkeys (Cercopithecus aethiops sabaeus)

Plasma catecholamines and social behavior in male vervet monkeys (Cercopithecus aethiops sabaeus)

A Study on the Acute Effect of Amphetamine on the Urinary Excretion of Biogenic Amines and Metabolites in Monkeys

Further evidence for the role of the caudate nucleus in programming motor and nonmotor behavior in Java monkeys

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