Adrenergic Blocking Agents. III. N-(Aryloxyisopropyl)-β-haloethylamines¹

!-Substituted 2,5-Bischloromethylpyrrolidines. A New Class of Adrenolytic Agents

“…or 5-5 mg/kg (p.o.) of ERL-491 reversed the pressor response to 1 • 5 µg/kg of ( -Epinephrine for approximately 90 min; [10][11][12][13][14][15][16][17][18][19][20] µg/kg (i.v.) or 5-0 mg/kg (p.o.)…”

A Synthesis of Formaldehyde-C14 1

“…Received November 2,1951 Adrenergic Blocking Agents. V. Synthesis of N -Benzyl -' -(1 -phenoxyisopropyl) -ßchloroethylamine Hydrochloride Labeled with C14 By Edward J. Nikawitz, William S. Gump, James F.…”

Toluene and its Derivatives as Atom-Efficient Benzylating Agents for Secondary Amines

“…20 examples, up to 80% yield R 3 R 3 10 mol% Ni(OTf) 2 10 mol% PPh 3 2.0 equiv NaHCO 3 2.0 equiv C 3 F 7 I 140 °C, 24 h + H Benzylation reactions of aromatic and aliphatic amines are important transformations in synthetic chemistry since the benzyl group is a frequently applied protecting group for this functionality. 1 Typically, N-benzylation is carried out via the reaction with benzyl bromide 2,3 or benzyl chloride, 4 via reductive amination with benzaldehyde, [5][6][7] or using benzylic alcohol in combination with a metal catalyst. 8,9 All these transformations have in common the need for a reactive functional group leading to the formation of an acid equivalent (in case of a halide) or the requirement for a subsequent transformation (e.g., reduction in case of reductive amination).…”