1973
DOI: 10.1161/01.res.33.1.82
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Adrenergic Component of Renin Release Induced by Vasodilating Antihypertensive Drugs in the Rat

Abstract: The capacity of the vasodilating drugs, minoxidil and hydralazine, for inducing renin release was characterized in rats according to chronology and dose response. Propranolol inhibition of this renin release was also characterized and related to serum levels of propranolol. Minoxidil and hydralazine (1.0 mg/kg) induced sevenfold elevations of serum renin activity. Treatment with propranolol, resulting in plasma propranolol concentrations as low as 50 ng/ml, impaired vasodilatory drug-induced renin release. The… Show more

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Cited by 100 publications
(51 citation statements)
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“…Several vasodilating agents have already been shown to increase renin release from the kidney (24)(25)(26). In the present study, intrarenal infusion of KB-2796 (30 ,ug/kg/min) increased PRA and RSR.…”
Section: Discussionsupporting
confidence: 61%
“…Several vasodilating agents have already been shown to increase renin release from the kidney (24)(25)(26). In the present study, intrarenal infusion of KB-2796 (30 ,ug/kg/min) increased PRA and RSR.…”
Section: Discussionsupporting
confidence: 61%
“…In all three studies there have been changes in the urinary electrolytes, so that renin release could have been stimulated by changes in ionic fluxes at the macula densa. /J-adrenergic stimulation produces renin release, and is involved in the renin response to vasodilators such as hydrallazine and minoxidil (Pettinger, Campbell & Keeton, 1973). However, fl-blockade does not alter the renin response to VIP in the conscious rabbit although the tachycardia is abolished.…”
Section: Discussionmentioning
confidence: 99%
“…The absence of discernible renin stimulation by dihydralazine was surprising, since hydralazine has been shown to provoke renin release in the intact rat (Pettinger et al, 1973). One explanation could be that dihydralazine is a weak stimulus and that its effect is not clearly distinguishable from the basal secretion rate as seen in the controls.…”
Section: Discussionmentioning
confidence: 98%