Adrenergic Gating of Hebbian Spike-Timing-Dependent Plasticity in Cortical Interneurons

Huang, Shiyong; Huganir, Richard L.; Kirkwood, Alfredo

doi:10.1523/jneurosci.5741-12.2013

Cited by 57 publications

(61 citation statements)

References 53 publications

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“…; Huang et al . ). To avoid fluorescence cross‐talk, fluorophores were imaged sequentially using a confocal microscope (SPE; Leica Microsystems, Wetzlar, Germany).…”

Section: Methodsmentioning

confidence: 97%

Synapse‐specific expression of calcium‐permeable AMPA receptors in neocortical layer 5

Lalanne

Oyrer

Mancino

et al. 2015

The Journal of Physiology

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Key points In the hippocampus, calcium‐permeable AMPA receptors have been found in a restricted subset of neuronal types that inhibit other neurons, although their localization in the neocortex is less well understood.In the present study, we looked for calcium‐permeable AMPA receptors in two distinct populations of neocortical inhibitory neurons: basket cells and Martinotti cells. We found them in the former but not in the latter. Furthermore, in basket cells, these receptors were associated with particularly fast responses.Computer modelling predicted (and experiments verified) that fast calcium‐permeable AMPA receptors enable basket cells to respond rapidly, such that they promptly inhibit neighbouring cells and shut down activity.The results obtained in the present study help our understanding of pathologies such as stroke and epilepsy that have been associated with disordered regulation of calcium‐permeable AMPA receptors. AbstractAMPA‐type glutamate receptors (AMPARs) lacking an edited GluA2 subunit are calcium‐permeable (CP) and contribute to synaptic plasticity in several hippocampal interneuron types, although their precise role in the neocortex is not well described. We explored the presence of CP‐AMPARs at pyramidal cell (PC) inputs to Martinotti cells (MCs) and basket cells (BCs) in layer 5 of the developing mouse visual cortex (postnatal days 12–21). GluA2 immunolabelling was stronger in MCs than in BCs. A differential presence of CP‐AMPARs at PC‐BC and PC‐MC synapses was confirmed electrophysiologically, based on measures of spermine‐dependent rectification and CP‐AMPAR blockade by 1‐naphtyl acetyl spermine using recordings from synaptically connected cell pairs, NPEC‐AMPA uncaging and miniature current recordings. In addition, CP‐AMPAR expression in BCs was correlated with rapidly decaying synaptic currents. Computer modelling predicted that this reduces spike latencies and sharpens suprathreshold responses in BCs, which we verified experimentally using the dynamic clamp technique. Thus, the synapse‐specific expression of CP‐AMPARs may critically influence both plasticity and information processing in neocortical microcircuits.

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“…; Huang et al . ). To avoid fluorescence cross‐talk, fluorophores were imaged sequentially using a confocal microscope (SPE; Leica Microsystems, Wetzlar, Germany).…”

Section: Methodsmentioning

confidence: 97%

Synapse‐specific expression of calcium‐permeable AMPA receptors in neocortical layer 5

Lalanne

Oyrer

Mancino

et al. 2015

The Journal of Physiology

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“…1b). Interestingly, activation of each pathway also suppresses the other, suggesting a push-pull rule for the neuromodulation of long-term synaptic plasticity [66] that seems to be independent of the underlying mechanisms of LTP and LTD [67 • ]. …”

Section: Neuromodulation Of Synaptic Dynamicsmentioning

confidence: 99%

Neuromodulation of neurons and synapses

Nadim

Bucher

2014

Current Opinion in Neurobiology

269

230

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Neuromodulation underlies the flexibility of neural circuit operation and behavior. Individual neuromodulators can have divergent actions in a neuron by targeting multiple physiological mechanisms. Conversely, multiple neuromodulators may have convergent actions through overlapping targets. Additionally, the divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic. Neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength. In addition, neuromodulators can exert effects at multiple timescales, from short-term adjustments of neuron and synapse function to persistent long-term regulation. This short review summarizes some highlights of the diverse actions of neuromodulators on ion channel and synaptic properties.

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“…Visual cortical slices (300 μm) were cut as described previously (Bridi et al, 2017;Gu et al, 2013;Huang et al, 2013;Huang et al, 2012) in ice-cold dissection buffer containing the following (in mM): 212.7 sucrose, 5 KCl, 1.25 NaH2PO4, 10 MgCl2, 0.5 CaCl2, 26 NaHCO3, 10 dextrose, bubbled with 95% O2/5% CO2, pH 7.4. Slices were transferred to normal artificial CSF (ACSF) at 30 ˚C for 30 min.…”

Section: Preparation Of Visual Cortical Slicesmentioning

confidence: 99%

Dynamic recovery from depression enables rate encoding in inhibitory synapses

Huang

Bridi

Kirkwood

2018

Preprint

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Fast-spiking parvalbumin positive interneurons (PV-INs) are essential for controlling network firing and the gain of the cortical response to sensory stimulation. Crucial for these functions, PV-INs can sustain high frequency firing with no accommodation. However, PV-INs also exhibit short-term depression (STD) during sustained activation, which is largely due to the depletion of synaptic resources (vesicles). In most synapses the rate of replenishment of depleted vesicles is constant, determining an inverse relationship between the STD level and the activation rate, which theoretically, severely limits rate coding capabilities. We examined STD of the PV-IN to pyramidal cell synapse in the mouse visual cortex, and found that in these synapses the recovery of depleted resources is not constant but increases linearly with the frequency of use. By combining modeling, dynamic clamp and optogenetics, we demonstrated that this dynamic regulation of recovery enables PV-INs to reduce pyramidal cell firing in a linear manner, which, theoretically, is crucial for controlling the gain of cortical visual responses.

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Adrenergic Gating of Hebbian Spike-Timing-Dependent Plasticity in Cortical Interneurons

Cited by 57 publications

References 53 publications

Synapse‐specific expression of calcium‐permeable AMPA receptors in neocortical layer 5

Synapse‐specific expression of calcium‐permeable AMPA receptors in neocortical layer 5

Neuromodulation of neurons and synapses

Dynamic recovery from depression enables rate encoding in inhibitory synapses

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