Adrenergic innervation and receptors in the sphincter of Oddi

Mori, Jyo; Azuma, Hiroshi; Fujiwara, Motohatsu

doi:10.1016/0014-2999(71)90191-9

Cited by 25 publications

(7 citation statements)

References 5 publications

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“…On the other hand, the response of the sphincter of Oddi to high concentrations of noradrenaline (10-5 to 10-4 M) can be explained by a excitatory and 9-inhibitory adrenergic mecha nisms, as already reported, since the contractile response to high concentrations of noradrenaline was enhanced by pretreat ment with propranolol and was inhibited by phentolamine. The discrepancy between our findings and those of other investigators may be due to different preparations and higher concentrations of sympathomimetic drugs (1)(2)(3)(4). Activation of the a-adrenoceptors in the sphincter of Oddi induced opposite responses, depending on the concentration of nor adrenaline.…”

Section: Discussioncontrasting

confidence: 99%

“…Excitatory a and inhibitory Q-adreno ceptors have been demonstrated in tissues such as the sphincter of Oddi and gallbladder (1)(2)(3)(4).…”

Section: Discussionmentioning

confidence: 99%

“…Muscle tone and motility of the biliary system are regulated by the autonomic nervous system, and the presence of cho linergic excitatory and adrenergic a-excitatory and 3-inhibitory receptors has been proposed (1)(2)(3)(4). The biliary system is also regulated by humoral agents such as cholecystokinin (CCK) and prostaglandins.…”

mentioning

confidence: 99%

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Effects of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi.

Nakata

Kurahashi

1981

Jpn.J.Pharmacol

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Abstract-Effects of C-terminal octapeptide of cholecystokinin (CB-CCK) and prostaglandins E1, E2 and F2ai on noradrenaline-induced responses and 3H -noradrenaline release in the gallbladder and sphincter of Oddi of guinea pigs were examined. In the sphincter of Oddi, noradrenaline in low concentrations induced a relaxation which was blocked by either phen tolamine or propranolol, while noradrenaline in high concentrations induced a contraction which was blocked by phentolamine. These results suggest the existence of excitatory and inhibitory a-receptors and inhibitory 8 receptors in the sphincter of Oddi. In the gallbladder, the adrenergic receptors are a-excitatory and (3-inhibitory. CB-CCK (10-9 g/ml) poten tiated both contractile and relaxing responses to noradrenaline, in the gallbladder. The same concentration of prostaglandins potentiated only contractile response to noradrenaline. In the sphincter of Oddi, nor adrenaline-induced responses were not affected by CB-CCK and prosta glandins. Prostaglandins inhibited 3H-efflux evoked by electrical stimu lation, while CB-CCK had no effect on the 3H-efflux from both preparations. These results suggest that CB-CCK enhances the contractile and relaxing responses to noradrenaline, and that prostaglandins act in a similar way on the postsynaptic response and, in addition, inhibit presynaptically the release of noradrenaline in the gallbladder. In the sphincter of Oddi, only prostaglandins inhibit the presynaptic event.

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Section: Discussioncontrasting

confidence: 99%

“…Excitatory a and inhibitory Q-adreno ceptors have been demonstrated in tissues such as the sphincter of Oddi and gallbladder (1)(2)(3)(4).…”

Section: Discussionmentioning

confidence: 99%

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Effects of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi.

Nakata

Kurahashi

1981

Jpn.J.Pharmacol

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“…The relationship of these fibres to the sphincter remain uncertain. They have been related to the sphincter musculature in dogs by Kydsola and Rechardt (7) and in guinea pigs and rabbits by Mori et al (8), but Baumgarten and Lange (1) believe that they are related to the adjacent blood vessels in cats, guinea pigs and rhesus monkeys. It is therefore not surpris ing that their physiological role is obscure.…”

Section: Discussionmentioning

confidence: 99%

Effects of Adrenergic Stimulation on the Choledochoduodenal Sphincter Mechanism

Broughton¹,

Secord²,

Scott³

1977

Pharmacology

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The object of this study was to assess the effects of systemic bolus injections of epinephrine and of norepinephrine upon the sphincter at the choledochoduodenal junction in the cat and the dog. The bile duct was transected and the downstream segment was cannulated. Two methods were used to assess sphincteric activity. In method I the bile duct was perfused with Ringer’s solution at a constant pressure and the flow rate of the solution was recorded. In method II the bile duct was perfused at a constant rate of flow and the terminal intraductal pressure was recorded. Intraduodenal pressure and respiratory movements were also recorded. There was a significant decrease in sphincteric activity following both epinephrine and norepinephrine administration in both cats and dogs, using both constant pressure and constant flow methods.

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“…Previous reports from our laboratory have shown that cholinergic innervation of the gall bladder and sphincter of Oddi in guinea pigs and rabbits are excitatory and that adrenergic innervation can be a-excitatory and ^-inhibitory (2,12,14,16). The biliary system is known to be also regulated by autacoids such as prosta glandins, as well as gastrointestinal hormones such as cholecystokinin (1, 8 -1 0 , 15, 17, 19 21).…”

Section: Introductionmentioning

confidence: 99%

Prostaglandins and the Contractility of the Guinea Pig Biliary System

Nakata¹,

Osumi²,

Fujiwara³

1981

Pharmacology

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The effects of exogenously applied prostaglandins on the contractile responses of the gallbladder and sphincter of Oddi isolated from guinea pigs were examined in normal and indomethacin-treated preparations. Indomethacin reduced the tone and the contractile responses to transmural stimulation and to exogenously applied ACh of the gallbladder, while the tone and contractile responses of the sphincter of Oddi were little affected by indomethacin. Prostaglandins E₁, E₂ and F₂_α potentiated the contractile responses of the gallbladder to transmural stimulation and ACh, and furthermore, treatment with indomethacin enhanced the potentiating effects of prostaglandins E₁ and E₂ but not the effect of PGF_2α. The reduced tone and contractility of the gallbladder were restored to the control level by addition of PGE₁ and PGE₂ but not by PGF_2α. These results suggest that endogenous PGE₁ and PGE₂ may play an important role in neurogenic control of contractility of the gallbladder, but not of the sphincter of Oddi.

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Adrenergic innervation and receptors in the sphincter of Oddi

Cited by 25 publications

References 5 publications

Effects of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi.

Effects of C-terminal octapeptide of cholecystokinin and prostaglandins on adrenergic functions in the guinea-pig gallbladder and sphincter of Oddi.

Effects of Adrenergic Stimulation on the Choledochoduodenal Sphincter Mechanism

Prostaglandins and the Contractility of the Guinea Pig Biliary System

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