Adrenergic mechanism in cold stored taenia caecum after rewarming

Shivata, Shoji; Miyahara, J. T.; Mori, Jo; Ohashi, Tomoo

doi:10.1016/0014-2999(77)90159-5

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…It had been believed for a long time that a prolonged cold storage causes an irreversible degeneration of adrenergic nerve fibres leading to a depletion of tissue catecholamines ( Shibata et al ., 1970 , 1971 , 1977 ). In 1993, Kristek et al .…”

Section: Discussionmentioning

confidence: 99%

Effects of prolonged cold storage on double peaked vasoconstrictor responses to periarterial nerve stimulation in isolated canine splenic arteries

Yang

Chiba

1999

British J Pharmacology

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1 P2X-Purinoceptors and a 1 -adrenoceptors have previously been shown to involve in the double peaked vasoconstrictor responses to periarterial electrical nerve stimulation in the isolated and perfused canine splenic artery. The present study made an attempt to investigate eects of prolonged cold storage (7 days at 48C) on vasoconstrictor responses to periarterial electrical nerve stimulation, tyramine, noradrenaline and adenosine 5'-triphosphate (ATP) in the isolated canine splenic artery. 2 The periarterial nerve stimulation (1 ± 10 Hz) readily causes a double peaked vasoconstriction in the non-stored preparations. After cold stored for 7 days, the double peaked vasoconstriction was still recognized, although the response became signi®cantly smaller. The ®rst phase was decreased relatively greater than the second phase by the cold storage. 3 In the cold stored preparations, the dose-response curve for tyramine was shifted to the right in a parallel manner. Prazosin almost completely inhibited tyramine-induced vasoconstriction but a,bmethylene ATP failed to in¯uence the response to tyramine. 4 The vasoconstrictor responses to noradrenaline and ATP were not signi®cantly modi®ed by the prolonged cold storage. 5 From these results, it is concluded that the functions of sympathetic co-transmission of purinergic components might be in¯uenced more than that of adrenergic components in the cold storage canine splenic artery.

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Section: Discussionmentioning

confidence: 99%

Effects of prolonged cold storage on double peaked vasoconstrictor responses to periarterial nerve stimulation in isolated canine splenic arteries

Yang

Chiba

1999

British J Pharmacology

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“…As a result, it was necessary to bring about the recovery of the decreased intraneuronal noradrenaline level in isolated small strips dissected from the atria 3-5 h after death. The supplies of oxygen and glucose in the Krebs solution can preserve the intraneuronal noradrenaline level for several hours or induce the recovery of the previously decreased transmitter pool (16)(17)(18).…”

Section: Methodsmentioning

confidence: 99%

Innervation of Atrial Stumps in Calves Living with the TNS‐Brno II Artificial Heart

Dolezel

Vasků²,

Hartmannová

et al. 1985

Artificial Organs

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The remnant stumps of the atria in six calves surviving with the artificial TNS-Brno II methacrylate heart for up to 5 months were examined by means of the Bodian silver-impregnating technique and by the formalin-induced fluorescence technique visualizing noradrenaline in monoaminergic nerve terminals. The degeneration of the nerve terminal system detected in animals surviving for 2 days and 1 week was followed by regeneration of the vegetative nerve system in four animals surviving for greater than 1 month. Moreover, thick myelinated nerves afferent in character were detected within the atrium of one animal surviving for 5 months.

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“…Shibata 27 has shown that fluorescence in adrenergic fibers is not always a reliable index of 6-OHDA depletion of NE, so 3 HNE uptake and content were also measured. CA uptake and retention were effectively curtailed as evidenced by the drastic reduction in the 3 HNE concentrations.…”

mentioning

confidence: 99%

Role of adrenergic nerves in blood-induced cerebral vasospasm.

Simeone¹,

Vinall²,

Alderman³

et al. 1979

Stroke

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Cerebral arteries have an abundant supply of adrenergic nerve fibers which are believed to release vasoactive substances responsible for the induction of cerebral vasospasm. To assess the importance of adrenergic nerves in this phenomenon, high doses (600 microgram/ml) of 6-hydroxydopamine (6-OHDA) were used to produce in vitro chemical sympathectomy in bovine middle cerebral artery. 6-OHDA reduced catecholamine fluorescence to undectable limits. H3-norepinephrine re-uptake was reduced to 1.5% of intact controls. Arterial norepinephrine content was reduced by 92%. Contractile responses to norepinephrine, serotonin, and fresh human whole blood were modestly reduced after denervation. This reduction was probably due to alpha receptor inactivation by 6-OHDA, because after protection of the alpha receptors with phentolamine the vessel response was the same as in untreated controls. Contractions in response to aged human whole blood were not affected by denervation. The results suggest that the endogenous release of catecholamines does not play a major role in the initiation or spread of blood-induced vasospasm in large cerebral arteries.

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Adrenergic mechanism in cold stored taenia caecum after rewarming

Cited by 5 publications

References 23 publications

Effects of prolonged cold storage on double peaked vasoconstrictor responses to periarterial nerve stimulation in isolated canine splenic arteries

Effects of prolonged cold storage on double peaked vasoconstrictor responses to periarterial nerve stimulation in isolated canine splenic arteries

Innervation of Atrial Stumps in Calves Living with the TNS‐Brno II Artificial Heart

Role of adrenergic nerves in blood-induced cerebral vasospasm.

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