Adrenergic mechanisms in canine mesenteric circulation

Swan, KG; Dg, Reynolds

doi:10.1152/ajplegacy.1971.220.6.1779

Cited by 36 publications

(17 citation statements)

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“…Increased sympathetic activity constricts the mesenteric arterioles and capacitance vessels. These responses are mediated by α-adrenergic receptors, which are predominant in the mesenteric circulation; however, β-adrenergic receptors are also present [52].…”

Section: Influence Of Neural Factorsmentioning

confidence: 99%

Functional vascular anatomy of the peritoneum in health and disease

Solaß

Horvath

Struller

et al. 2019

Pleura and Peritoneum

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Abstract:The peritoneum consists of a layer of mesothelial cells on a connective tissue base which is perfused with circulatory and lymphatic vessels. Total effective blood flow to the human peritoneum is estimated between 60 and 100 mL/min, representing 1-2 % of the cardiac outflow. The parietal peritoneum accounts for about 30 % of the peritoneal surface (anterior abdominal wall 4 %) and is vascularized from the circumflex, iliac, lumbar, intercostal, and epigastric arteries, giving rise to a quadrangular network of large, parallel blood vessels and their perpendicular offshoots. Parietal vessels drain into the inferior vena cava. The visceral peritoneum accounts for 70 % of the peritoneal surface and derives its blood supply from the three major arteries that supply the splanchnic organs, celiac and superior and inferior mesenteric. These vessels give rise to smaller arteries that anastomose extensively. The visceral peritoneum drains into the portal vein. Drugs absorbed are subject to firstpass hepatic metabolism. Peritoneal inflammation and cancer invasion induce neoangiogenesis, leading to the development of an important microvascular network. Anatomy of neovessels is abnormal and characterized by large size, varying diameter, convolution and blood extravasation. Neovessels have a defective ultrastructure: formation of large "mother vessels" requires degradation of venular and capillary basement membranes. Mother vessels give birth to numerous "daughter vessels". Diffuse neoangiogenesis can be observed before appearance of macroscopic peritoneal metastasis. Multiplication of the peritoneal capillary surface by neoangiogenesis surface increases the part of cardiac outflow directed to the peritoneum.

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Section: Influence Of Neural Factorsmentioning

confidence: 99%

Functional vascular anatomy of the peritoneum in health and disease

Solaß

Horvath

Struller

et al. 2019

Pleura and Peritoneum

View full text Add to dashboard Cite

show abstract

“…But it is speculated that its inhibitory effects do not depend on the activity o f exogeneous gut hormones and pancreatic blood flow [1,4,7,8], but that it acts on the nerve o f the acinar cells o f the pancreas [1,4]. In other words, these observations support evidence that (3-adrenergic stimulators act in the splanchnic nervous system o f the acinar cells, resulting in inhibition o f the exocrine pancreatic secretion.…”

Section: Discussionmentioning

confidence: 95%

Clinical Evaluation of Terbutaline Sulfate as a Potential Agent for Treating Anastomotic Leakage after Gastric Operation: Effect of Terbutaline Sulfate on Pancreatic Exocrine Secretion

Nagami¹,

Tamura²,

Kin³

et al. 1995

Dig Surg

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Clinical advantage of terbutaline sulfate (Bricanyl®) was evaluated in 6 patients with anastomotic leakage after gastric operation. Terbutaline sulfate was administered subcutaneously for the purpose of inhibiting exocrine pancreatic secretion during 3 or 4 weeks just after anastomotic leakage was recognized by postoperative upper gastrointestinal series (GIS). We first used the conventional treatment for any anastomotic gastric leakage; intravenous hyperalimentation, nasogastric intubation, antibiotics etc. In addition to these conventional treatments, we added terbutaline sulfate to inhibit pancreatic exocrine secretion. With this treatment, exudates from anastomotic leakage and the levels of pancreatic exocrine enzyme were gradually decreased and eventually the injured anastomosis was completely healed in all cases. In conclusion, treatment with terbutaline sulfate could possibly be useful for stopping anastomotic leakage after gastric operation. The important mechanism by which pancreatic exocrine secretion is inhibited by terbutaline sulfate administration may be due to direct action to the acinar cells of the pancreas.

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“…The increase of INA during norepinephrine administration is in a direction opposite to the expected effect of the four major baroceptor reflex. It has been shown that the injection of epinephrine or norepinephrine causes the portal blood pressure to increase (SEMBA, 1954;SWAN and REYNOLDS, 1971). Although the origin of the increase in INA during norepinephrine administration is not yet clear, recent findings (ANDREWS et al, 1972) of the presence of mesentery "venous volume" or "stretch" receptors in the portal vein suggest that norepinephrine caused the portal blood pressure to increase and this in turn caused an increase in the efferent nerve discharge to the intestine.…”

Section: Resultsmentioning

confidence: 99%

Efferent Activity in Renal and Intestinal Nerves During Circulatory Reflexes

1973

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Summary The effects of baroceptor reflex on the sympathetic nerve activity to the intestine (INA) and kidney (RNA) were compared in anesthetized cats. Grouped discharges synchronous with the cardiac cycle was not the major pattern in INA and approximately 73 % of the total INA was composed of a continuous or fluctuating pattern. With increase in mean aortic pressure from 116 to 216 mmHg after administration of norepinephrine, INA showed various response patterns : initial inhibition followed by an increase (Type A), increase without inhibition (Type B), slight inhibition (Type C) and no change (Type D), whereas RNA decreased to the noise level. Type A and B were the most common response patterns. In the open loop condition, initial inhibition in Type A disappeared, while the increase of INA in Types A and B remained unchanged. When RNA was completely inhibited by baroceptor inputs during occlusion of the descending thoracic aorta, INA was not inhibited but rather slightly increased. It is concluded that INA showed quantitatively and qualitatively different responses to baroceptor inputs as compared to RNA.

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Adrenergic mechanisms in canine mesenteric circulation

Cited by 36 publications

References 0 publications

Functional vascular anatomy of the peritoneum in health and disease

Functional vascular anatomy of the peritoneum in health and disease

Clinical Evaluation of Terbutaline Sulfate as a Potential Agent for Treating Anastomotic Leakage after Gastric Operation: Effect of Terbutaline Sulfate on Pancreatic Exocrine Secretion

Efferent Activity in Renal and Intestinal Nerves During Circulatory Reflexes

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