Adrenergic Receptor (ADR) Genotypes Influence the Effects of Strength Training on Mid-Thigh Intermuscular Adipose Tissue

Yao, Lili; Delmonico, Mattew J.; Hand, Brian D.; Johns, Joshua; Hurley, Ben F.

doi:10.1249/00005768-200605001-01095

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“…First, our subject pool was limited to postmenopausal women in the sedentary state. This was done to reduce inter-subject variability as it has been well established in the literature that age, sex and exercise training state are associated with variation in thigh skeletal muscle composition (Maughan et al, 1983;Fiatarone et al, 1990;Conley et al, 1995;Sipila & Suominen, 1995;Frontera et al, 2000;Yao et al, 2007). Secondly, the Berg et al (1993) study employed both CT technology and BIA in an effort to establish whether fluid shifting out of the lower limbs was associated with changes in mid-thigh CSA.…”

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confidence: 99%

Effects of acute supine rest on mid‐thigh cross‐sectional area as measured by computed tomography

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Delmonico

Lindle

et al. 2007

Clin Physio Funct Imaging

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The loss of hydrostatic pressure that occurs as a person moves from the standing to the supine position causes a fluid redistribution that may confound the measurement of thigh cross-sectional area (CSA) if data are obtained while tissue fluid content is in flux. To determine the effects of changing postural position on thigh tissue CSA, mid-thigh axial scans of 13 older women were obtained at 5, 10 and 15 min of supine rest using computed tomography (CT). Scans were analysed for changes in CSA of subcutaneous fat (SF), low density muscle (LDM) and normal density muscle (NDM). A significant decrease from baseline was found in the CSA of NDM at 15 min [2.3+/-0.8 cm2 (+/-SE), 1.6%, P<0.05], with no change in LDM or SF CSA among any of the time intervals. The results of the current study suggest that potential measurement error can be minimized when baseline and follow-up CT-derived images of mid-thigh CSA are obtained within the first 10 min the subject assumes the supine position and that the CSA of NDM and LDM may be affected differently by supine rest.

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