??-Adrenergic Receptor Blocking Drugs in Hyperthyroidism

Turner, Paul

doi:10.2165/00003495-197407010-00004

Cited by 45 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past few years, the use of,-adrenoceptor blocking drugs, particularly propranolol, has become established in various aspects of the management of hyperthyroidism (Turner, 1974;McDevitt, 1976). No information is currently available on the influence of thyroid disease on the metabolism of ,B-adrenoceptor blocking drugs.…”

Section: Studies Of the Effect Of Thyroid Dysfunction On The Eliminatmentioning

confidence: 99%

Studies of the effect of thyroid dysfunction on the elimination of beta‐ adrenoreceptor blocking drugs.

Bell¹,

Russell²,

Nelson³

et al. 1977

Brit J Clinical Pharma

View full text Add to dashboard Cite

Section: Studies Of the Effect Of Thyroid Dysfunction On The Eliminatmentioning

confidence: 99%

Studies of the effect of thyroid dysfunction on the elimination of beta‐ adrenoreceptor blocking drugs.

Bell¹,

Russell²,

Nelson³

et al. 1977

Brit J Clinical Pharma

View full text Add to dashboard Cite

“…Prior to 1960, the hyperdynamic circulatory state of hyperthyroidism was ascribed to catecholamine hypersensitivity said to occur in this disease (Harrison, 1964;Waldenstein, 1966) and the existence of such hypersensitivity is still widely believed and quoted (Turner, 1974;Turner, 1976). However, the investigations on which this concept was based have been criticised because they were largely uncontrolled and because they failed to examine concentration -response relationships to catecholamines, essential to conclusions regarding sensitivity (Levey, 1971).…”

Section: Introductionmentioning

confidence: 99%

Catecholamine sensitivity in hyperthyroidism and hypothyroidism.

McDevitt¹,

Riddell²,

Hadden³

et al. 1978

Brit J Clinical Pharma

View full text Add to dashboard Cite

1. Catecholamine sensitivity in hyper‐ and hypothyroidism has been studied using a standardised isoprenaline sensitivity test. 2. Seven patients with hyperthyroidism and seven with hypothyroidism were tested both when showing evidence of thyroid dysfunction and again when euthyroid. 3. No significant differences were seen in heart rate responses to isoprenaline when patients became euthyroid compared to their response when either hyperthyroid or hypothyroid. 4. These results indicate that sensitivity to catecholamines is not altered in thyroid dysfunction and, in particular, that hypersensitivity does not occur in spontaneous hyperthyroidism.

show abstract

“…On the basis of their apparently different effect on resting heart rate in patients with hyperthroidism, distinction has been drawn between ,B-adrenoceptor blocking drugs without intrinsic sympathomimetic activity (propranolol, and those possessing such activity (alprenolol, oxprenolol, pindolol and practolol) (Turner, 1974). Drugs of the former group produce significant dose-dependent slowing of resting heart rate in such patients, whereas those of the latter group do not.…”

Section: Introductionmentioning

confidence: 99%

“…Drugs of the former group produce significant dose-dependent slowing of resting heart rate in such patients, whereas those of the latter group do not. The lesser effectiveness of the second group has been attributed to their intrinsic sympathomimetic activity and to the increased sensitivity to adrenergic receptor stimulation said to occur in hyperthyroidism (Turner & Hill, 1968) and it has been concluded that only those 3-adrenergic receptor blocking drugs without intrinsic sympathomimetic activity are predictably effective in hyperthyroidism (Turner, 1974).…”

Section: Introductionmentioning

confidence: 99%

Comparative trial of propranolol and practolol in hyperthyroidism.

Nelson¹,

McDevitt²

1975

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The possible role of practolol in the management of hyperthyroidism has been studied by comparing it with propranolol. 2 In a double-blind cross-over trial, propranolol (40 mg), practolol (120 mg) and a placebo four times daily for one week were compared in twenty-one hyperthyroid patients by sequential analysis. 3 Judged by their effect on the symptoms and signs of thyrotoxicosis, both propranolol and practolol were significantly better than the placebo but no clear distinction could be made between the two active compounds. 4 Propranolol and practolol reduced heart rate by 24 and 17% respectively compared with placebo. 5 Patients generally preferred propranolol or practolol to placebo but this preference did not achieve significance with either drug. 6 Only in its effect on heart rate was practolol significantly inferior to propranolol, and it would appear to be a useful alternative to propranolol in the management of the peripheral manifestations of hyperthyroidism.

show abstract

??-Adrenergic Receptor Blocking Drugs in Hyperthyroidism

Cited by 45 publications

References 24 publications

Studies of the effect of thyroid dysfunction on the elimination of beta‐ adrenoreceptor blocking drugs.

Studies of the effect of thyroid dysfunction on the elimination of beta‐ adrenoreceptor blocking drugs.

Catecholamine sensitivity in hyperthyroidism and hypothyroidism.

Comparative trial of propranolol and practolol in hyperthyroidism.

Contact Info

Product

Resources

About