Adrenergic regulation of catecholamine secretion from trout (Oncorhynchus mykiss) chromaffin cells

Montpetit, CJ; Perry, Steven F.

doi:10.1677/joe.0.1730187

Cited by 15 publications

(5 citation statements)

References 44 publications

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“…It functions as a physiological modulator of CA secretion by non-competitively suppressing ACh-induced cytosolic Ca 2+ dynamics in bovine adrenal chromaffin cells (Suzuki et al, 1999). And also there had a feedback inhibition of CA secretion by activating chromaffin cell membrane beta (2) -receptors and presynaptic alpha (2) -adrenergic receptors (Montpetit and Perry, 2002).…”

Section: Discussionmentioning

confidence: 99%

Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells

Mao¹,

Zhang²,

Wang³

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells

Mao¹,

Zhang²,

Wang³

et al. 2009

Journal of Ethnopharmacology

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“…A systematic study revealed which function of the carp immune system was most affected by hypoxic stress and how the duration of stress influences the expression of these functions. Acute stress enhances the fast pathway that activates the sympathetic nervous system to release catecholamines, such as adrenaline and noradrenaline, from chromaffin cells in the head kidney, and the released catecholamines bind to their receptors in leucocytes [ 101 , 102 ]. As a result, the proinflammatory function (IL‐1b, IL‐6 and tumour necrotic factor α (TNFa)) is upregulated and, at the same time, the activity of regulatory function (TGFb and IL‐10) is upregulated, probably in order to return proinflammatory activity to homeostasis [ 100 , 103 ].…”

Section: Influence Of Stress On the Immune Systemmentioning

confidence: 99%

Influence of chronic stress on the mechanism of the cytotoxic system in common carp (Cyprinuscarpio)

Shimon-Hophy

Avtalion

2021

Immunology

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Aquaculture conditions expose fish to internal and environmental stressors that increase their susceptibility to morbidity and mortality. The brain accumulates stress signals and processes them according to the intensity, frequency duration and type of stress, recruiting several brain functions to activate the autonomic or limbic system. Triggering the autonomic system causes the rapid release of catecholamines, such as adrenaline and noradrenaline, into circulation from chromaffin cells in the head kidney. Catecholamines trigger blood cells to release proinflammatory and regulatory cytokines to cope with acute stress. Activation of the limbic axis stimulates the dorsolateral and dorsomedial pallium to process emotions, memory, behaviour and the activation of preoptic nucleus-pituitary gland-interrenal cells in the head kidney, releasing glucocorticoids, such as cortisol to the bloodstream. Glucocorticoids cause downregulation of various immune system functions depending on the duration, intensity and type of chronic stress. As stress persists, most immune functions, with the exception of cytotoxic functions, overcome these effects and return to homeostasis. The deterioration of cytotoxic functions during chronic stress appears to be responsible for increased morbidity and mortality.

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“…In a study on β‐adrenergic effects on insulin signaling in adipocytes from β 3 ‐adrenoceptor “knock‐out mice”, dobutamine was used as “the classical β 1 ‐adrenoceptor agonist” (Jost et al 2002). Furthermore, dobutamine was employed to investigate the mechanism of adrenergic inhibition of catecholamine secretion from trout cromaffin cells in vitro (Montpepit & Perry 2002) and to test “the hypothesis that nitric oxide has a positive inotropic effect on mammalian cardiac muscle contractility and that this effect sums with the positive inotropic effect of β 1 ‐adrenergic agonists when both are present” (Reading & Barclay 2002). None of these authors appear to have considered the chiral nature of dobutamine.…”

Section: Classical Delusionsmentioning

confidence: 99%

Three‐Dimensional Pharmacology, a Subject Ranging from Ignorance to Overstatements

Waldeck

2003

Pharmacology & Toxicology

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Stereoselectivity has been known to play a role in drug action for 100 years or more. Nevertheless, chiral drugs have been developed and used as racemates, neglecting the fact that they comprise mixtures of two or more compounds which may have quite different pharmacological properties. A very limited access to pure enantiomers in the past has been responsible for this unsatisfactory state of affairs. During the last 20 years, significant achievements have made it possible to perform stereoselective synthesis and analysis. Today, novel chiral drugs are as a rule developed as single enantiomers. Yet, studies of old racaemic drugs are still designed, performed and published without mention of the fact that two or more compounds are involved. In recent years, a number of old racaemic drugs have been re-evaluated and re-introduced into the clinical area as the pure, active enantiomer (the eutomer). While in principle correct, the clinical benefit of this shift from a well established racaemate to a pure enantiomer often seems to be limited and sometimes exaggerated. Racaemic drugs with a deleterious enantiomer that does not contribute to the therapeutic effect (the distomer), may have been sorted out in the safety evaluation process. However, in the future any pharmacological study of racaemic drugs must include the pure enantiomers. This will generate new, valuable information on stereoselectivity in drug action and interaction.The interaction between a drug and its receptor is a threedimensional event. If the drug molecule is chiral, thus forming optically active isomers, this interaction is usually stereoselective. The first definitive example of a difference in pharmacological action between optical isomers, or enantiomers, of a chiral molecule was offered by Arthur Cushny almost hundred years ago. He showed that the natural, levorotatory alkaloid hyoscyamine was twice as potent as its racaemic form, atropine, in antagonizing cholinergic stimuli. Moreover, Cushny was able to show that endogenous adrenaline, which is also levorotatory, is twice as potent as synthetic adrenaline which is racaemic. The dextrorotatory isomer of adrenaline was much less potent. These and other fundamental observations were discussed in a monograph (Cushny 1926). A few years later, Easson & Stedman (1933) postulated a three-point interaction between a drug and its receptor to explain stereoselectivity in drug action.Despite this early understanding of the problem, chiral drugs were developed and used as racemates throughout the twentieth century, often on the assumption that only one enantiomer (the eutomer) is pharmacologically active in relevant doses and that the counterpart (the distomer) is inactive as well as harmless. A major reason for this policy was

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Adrenergic regulation of catecholamine secretion from trout (Oncorhynchus mykiss) chromaffin cells

Cited by 15 publications

References 44 publications

Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells

Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells

Influence of chronic stress on the mechanism of the cytotoxic system in common carp (Cyprinuscarpio)

Three‐Dimensional Pharmacology, a Subject Ranging from Ignorance to Overstatements

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