Adrenergic regulation of total systemic distensibility

Rutlen, D. L.; Supple, E W; Powell, Wilson M.

doi:10.1016/0002-9149(81)90541-5

Cited by 14 publications

(6 citation statements)

References 10 publications

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“…The animals were ventilated with a Bird Mark 7 constant pressure respirator (Bird Corp., Palm Springs, CA) using 97% 02 and 3% Co2. A right lateral thoracotomy was performed and a total cardiopulmonary bypass preparation, which has previously been used in our laboratory to study vascular capacity (23,24), was used (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

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Effect of prostacyclin on vascular capacity in the dog.

Fulghum¹,

DiMarco²,

Supple³

et al. 1985

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

“…1). After heparin administration ( (23,24). Computer-assisted regression lines were drawn through the control period and the lines were extrapolated for oxygenator blood volume throughout the study as previously described (24).…”

Section: Introductionmentioning

confidence: 99%

Effect of prostacyclin on vascular capacity in the dog.

Fulghum¹,

DiMarco²,

Supple³

et al. 1985

J. Clin. Invest.

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“…Therefore, centhaquine increases venous return and cardiac output while facilitating tissue perfusion. This is confirmed by several experimental studies and clinical trials, which showed the superior effectiveness of centhaquine compared to commonly used resuscitative agents in reducing mortality following hemorrhagic shock [ 14 , 15 , 16 , 17 ]. Of note, centhaquine is the only late-stage clinical developmental drug that has demonstrated an 8.8% absolute reduction in mortality after hypovolemic shock.…”

Section: Introductionmentioning

confidence: 60%

“…Centhaquine (2-[2-(4-(3-methyphenyl)-1-piperazinyl)]ethyl-quinoline) citrate is a novel vasopressor acting on α2B-adrenoreceptors which are abundantly present in veins while scarcely present in arteries, contributing most to venoconstriction [ 14 ]. It also activates central α2A-adrenoreceptors, reducing systemic vascular resistance and afterload by attenuating sympathetic outflow.…”

Section: Introductionmentioning

confidence: 99%

Effect of Centhaquine on the Coagulation Cascade in Normal State and Uncontrolled Hemorrhage: A Multiphase Study Combining Ex Vivo and In Vivo Experiments in Different Species

Chalkias,

Pais,

Gulati

2024

IJMS

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Centhaquine is a novel vasopressor acting on α2A- and α2B-adrenoreceptors, increasing venous return and improving tissue perfusion. We investigated the effects of centhaquine on blood coagulation in normal state and uncontrolled hemorrhage using ex vivo and in vivo experiments in different species. Thromboelastography (TEG) parameters included clotting time (R), clot kinetics [K and angle (α)], clot strength (MA), and percent lysis 30 min post-MA (LY30). In normal rat blood, centhaquine did not alter R, K, α, MA, or LY30 values of the normal vehicle group or the antithrombotic effects of aspirin and heparin. Subsequently, New Zealand white rabbits with uncontrolled hemorrhage were assigned to three resuscitation groups: Sal-MAP 45 group (normal saline to maintain a mean arterial pressure, MAP, of 45 mmHg), Centh-MAP 45 group (0.05 mg kg−1 centhaquine plus normal saline to maintain a MAP of 45 mmHg), and Sal-MAP 60 group (normal saline to maintain a MAP of 60 mmHg). The Sal-MAP 45 group was characterized by no change in R, reduced K and MA, and increased α. In the Centh-MAP 45 group, TEG showed no change in R, K, and α compared to saline; however, MA increased significantly (p = 0.018). In the Sal-MAP 60 group, TEG showed no change in R, an increase in α (p < 0.001), a decrease in K (p < 0.01), and a decrease in MA (p = 0.029) compared to the Centh-MAP 45 group. In conclusion, centhaquine does not impair coagulation and facilitates hemostatic resuscitation.

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“…In the latter case (severe hypovolemia), veins are usually maximally constricted and exogenous pure alpha-1 adrenergic agonists (e.g., phenylephrine) would not further increase venoconstriction and will only constrict arteries [41,42]. On the contrary, the activation of the abundant alpha-adrenergic receptors in the (already constricted) hepatic veins increases the impedance of the outflow of blood from the splanchnic system into systemic circulation, which leads to sequestration of blood within the liver [43][44][45][46][47], possibly depriving a valuable amount of volume (autotransfusion) from the systemic circulation (venous return), while further constriction of arteries aggravates tissue perfusion and hypoxia. Compared to alpha-1 adrenergic agonists, norepinephrine might exert an additional benefit by stimulation of beta-2 adrenoceptors, facilitating emptying of the venous system, but may also decrease pulmonary vascular compliance [45,46].…”

Section: Perspectivesmentioning

confidence: 99%

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

Laou,

Papagiannakis,

Papadopoulou

et al. 2023

Preprint

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Background: The clinical impact of vasopressin in hemorrhagic shock remains largely unknown. Objective: This systematic review and meta-analysis was designed to investigate the effects of vasopressin receptor agonists during the resuscitation of hemorrhagic shock. Methods: A systematic search of PubMed (MEDLINE), Scopus, and PubMed Central was conducted for relevant articles. Preclinical (animal) and clinical studies were included. The primary objective was to investigate the correlation of vasopressin receptor agonist use with mortality and various hemodynamic parameters. Results: Data extraction was possible in 13 animal studies and two clinical studies. Differences in risk of mortality between patients who received a vasopressin receptor agonist were not statistically significant when compared to those who were not treated with such agents [RR (95%CI): 1.17 (0.67, 2.08); p=0.562; I2 = 50%]. The available data were insufficient to conduct a meta-analysis assessing the effect of vasopressin receptor agonists on hemodynamics. Drawing safe conclusions from animal studies was challenging, due to significant heterogeneity in terms of species and dosage of vasopressin receptor agonists across studies. Conclusions: Differences in risk of mortality between patients who received a vasopressin receptor agonist were not statistically significant when compared to those who were not treated with such agents after hemorrhagic shock.

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Adrenergic regulation of total systemic distensibility

Cited by 14 publications

References 10 publications

Effect of prostacyclin on vascular capacity in the dog.

Effect of prostacyclin on vascular capacity in the dog.

Effect of Centhaquine on the Coagulation Cascade in Normal State and Uncontrolled Hemorrhage: A Multiphase Study Combining Ex Vivo and In Vivo Experiments in Different Species

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

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