Adrenic acid Δ4 desaturation and fatty acid composition in the liver of marine-oil fed streptozotocin diabetic rats

Long-term streptozotocin diabetes impairs arachidonic and docosahexaenoic acid metabolism and ∆5 desaturation indices in aged rats

“…The expression of transcription factors such as PPARs is also changed Son et al, 2007) and in some experiments insulin restores values to normal . The most consistent changes in the fatty acid composition of different tissues in IDDM experimental rats include: a decrease in palmitic acid (Chanussot et al, 1997;Comte et al, 2004;Ghebremeskel et al, 2002;Malaisse et al, 2006) and a decrease in monounsaturated fatty acids (MUFA) (Comte et al, 2004;Montanaro et al, 2005). Other important changes are not consistent and include a decrease in 20:4n6 and/or increase in its precursors (18:2n6 and 20:3n6), and an unusual increase in 22:6n3 (Brenner, 2003).…”