Adrenocortical factors in hypertension

Ulick, Stanley

doi:10.1016/0002-9149(76)90360-x

Cited by 54 publications

(4 citation statements)

References 68 publications

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“…DOC, unlike 19-nor-DOC, is a relatively weak mineralocorticoid and is seldom elevated to biologically significant levels. 12 l5 l6 The increased TH-DOC in the present study is by itself unlikely to be physiologically significant, but increased DOC could be a marker for altered adrenocortical steroid synthesis. Furthermore, subtle increases in DOC can be demonstrated by ACTH-induced DOC responses wheh are selectively increased in low-renin hypertension.…”

Section: Discussionmentioning

confidence: 67%

Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.

Griffing¹,

Dale²,

Holbrook³

et al. 1983

Hypertension

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SUMMARY A number of mineralocorticoids have been proposed as etiologic factors in low-renin hypertension. In this study, urinary free 19-nor-deoxycorticosterone (UF 19-nor-DOC) was compared to other mineralocorticoids -aldosterone, deoxycorticosterone (DOC), and 18-OH-DOC, in 11 lowrenin hypertensive patients on a controlled diet in a metabolic unit. Results demonstrated that both UF 19-nor-DOC and tetrahydro-DOC (TH-DOC) excretion were elevated (2086 ± 926, nl = 339-579 ng/day, and 18 ± 7, nl = 5-15 meg/day, respectively), and positively correlated (r = 0.95). Neither 18-OH-DOC nor aldosterone secretion rates were elevated, and neither of these hormones correlated with UF 19-nor-DOC, with exception of the supine plasma aldosterone (SPA) (r = 0.86). In conclusion, both UF 19-nor-DOC and TH-DOC were increased and positively correlated in the present series of hypertensives. This association is possibly indicative of a precursor-product relationship between DOC and 19-nor-DOC. 19-Nor-DOC, furthermore, correlated with supine plasma aldosterone (SPA), which could, in part, reflect their shared adrenocorticotropic hormone (ACTH) dependence.

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Section: Discussionmentioning

confidence: 67%

Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.

Griffing¹,

Dale²,

Holbrook³

et al. 1983

Hypertension

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“…The product formed at this temperature has a less intense X-ray diffraction pattern than in the case of the higher hydrate. According to the IR spectrum, another component is found in this product besides the deca- [8] 480 s 590m 820 vs 1020m vanadate of magnesium. This component contains vanadium(IV), the amount of which increases in the mixture in parallel with increasing temperature.…”

Section: Resultsmentioning

confidence: 84%

“…In the IR spectrum of the product (Table 3), besides the vibrations belonging to ~t-Cd(VO3)2, there occur further ones at 1000 and 1015 cm -1. Taking this as well as study of the entire IR spectrum into account, it is possible to elim- Table 3 Wavenumbers of Cd3VloO2a " i 6 H20 and of the products of thermal decomposition, in cm-t a-Cd(VO3)2 [8] 565--585 vs 850 s 960m V.~Os [8] 480 s 590m 820 s 1020m inate the possibility of the presence of a lower oxide of vanadium in the product [9]. It is therefore reasonable to presume that the vanadium in the oxidation state IV is a constituent of vanadium bronze.…”

Section: Resultsmentioning

confidence: 99%

Thermal decomposition of decavanadates of bivalent metals

Ulická¹

1980

Journal of Thermal Analysis

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The thermal decomposition of CdaVloOzs " 16HaO and MgaV100~s " 18H:O has been investigated. It was found by means of IR spectroscopy and X-ray phase analysis that the final products of decomposition of the given compounds are V.On, the corresponding metavanadates and the vanadium bronzes of cadmium and magnesium. Present and previous results allow conclusions on the thermal decomposition of decavanadates of bivalent metals.The thermal reactivity of deeavanadates has become the subject of thorough research only in the last few years. Recent results have brought not only new information but also stimuli for further research.Analysis of the thermal properties of decavanadates of bivalent metals has been carried out in the cases of ZnaVi0028 " 16H20 [1], CaaV1002s " 16H~.O, SraVloO2~' 24 H,,O and BaaVl002 a 9 19 H20 [2]. Further research into decavanadates proved to be necessary for the explanation of certain phenomena connected with the thermal decomposition of the given compounds and also for purposes of obtaining a larger number of experimental data.The present paper deals with the problem of dehydration and thermal decomposition of CdaVmO,~ 8 " 16 H,,O and MgaVmO2s " 18 H20. ExperimentalCdaVloO:, ~ " 16 H20 and MgaVloOzs 9 18 HzO were prepared by the reaction of HaV1002s with the corresponding acetates [3].The cadmium or magnesium content was determined complexometrically [4]. Vanadium(V) was determined volumetrically by titrating with a 0.1 N solution of iron(II) sulphate using diphenylamine as indicator [5], and vanadium(IV) by titrating with a 0.01 M solution of potassium permanganate [5], but also qualitatively by using e.p.r, spectra. The amount of crystal water was estimated by drying the substances at 350 ~ as well as by DTA.For CdaVloO28 The thermal analysis of the compounds was performed on the Paulik-PaulikErdey derivatograph (MOM, Budapest), sample weight 200 mg. Gaseous products were sucked off by a water pump. For the study of the processes connected with heating of the compounds, products obtained by interrupted DTA, by drying over silica gel, and by isothermal heating at definite temperatures in a crucible furnace, were used. The samples obtained isothermally were always heated to constant weight and investigated by means of IR spectroscopy and X-ray phase analysis.The infrared spectra were taken on a Perkin-Elmer type 221 instrument, with the Nujol technique.X-ray diffraction patterns were taken on a Philips PW 1058 diffractograph equipped with a copper anticathode and a nickel filter.The e.p.r, spectra were taken on a Varian instrument of the Strong Pitch type (modulation amplitude 10 G, frequency 9.5 GHz, power of microwave radiation 25 mW, sensitivity 5 " 10a-2 9 105). Results and discussionThe results of differential thermal analysis of CdaVloO2s 9 16 HzO are shown in Fig. 1. The DTA curve indicates two r processes within the temperature range 75-240 ~ These are immediately followed by an r protess (max. at 265~ By long-term drying of CdaV1002s " 16 1-120 over silica gel, it is possible to ob...

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“…5. Several investigators [8,[15][16][17][18] have produced evidence that indicates the one enzyme, P-450 aldo (P-45011B2), introduces, in vitro, two oxygen atoms into deoxycorticosterone, one at C-11 and the other at C-18.…”

Section: Some New Proposals For the Oxidative Processes Involved In Smentioning

confidence: 99%

Other conceivable renditions of some of the oxidative processes used in the biosynthesis of steroid hormones

Lieberman

Kaushik

2006

The Journal of Steroid Biochemistry and Molecular Biology

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Adrenocortical factors in hypertension

Cited by 54 publications

References 68 publications

Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.

Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.

Thermal decomposition of decavanadates of bivalent metals

Other conceivable renditions of some of the oxidative processes used in the biosynthesis of steroid hormones

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