Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Ohashi, Masao; Kato, Kanefusa; Nawata, Hajime; Itoh, Hiroshi

doi:10.1159/000212764

Cited by 70 publications

(32 citation statements)

References 8 publications

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“…These findings are consistent with the previous observation that the basal concentration and response to ACTH of plasma cortisol and aldosterone in aged men are essentially the same as those in young men (Ohashi et al, 1986).…”

Section: Discussionsupporting

confidence: 93%

Evidence for Age-Related Change in Plasma 19-Hydroxyandrostenedione.

et al. 1989

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The steroid, 19-hydroxyandrost-4-ene-3, 17-dione (19-hydroxyandrostenedione, 19-OH-A-dione) has been known to enhance the mineralocorticoid action of aldosterone. To investigate the age-related change in the plasma 19-OH-Adione concentration, plasma 19-OH-A-dione, androst-4-ene-3, 17-dione (A-dione), aldosterone and cortisol of 38 non-hypertensive healthy subjects (18 young men and 20 aged men) measured by specific radioimmunoassays.The basal plasma 19-OH-A-dione and A-dione concentration in aged men was significantly lower than in young men (P<0.01).Moreover, there was found to be a positive correlation between plasma 19-OH-A-dione and A-dione (P<0.01). On the other hand, plasma aldosterone and cortisol in aged men showed a tendency to decrease, but no statistical significance compared to young men was observed. This study demonstrated that there was an apparent age-related decrease not only in plasma A-dione, but also in plasma 19-OH-A-dione, an amplifier of aldosterone action.

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Section: Discussionsupporting

confidence: 93%

Evidence for Age-Related Change in Plasma 19-Hydroxyandrostenedione.

et al. 1989

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“…In conscious and healthy normotensive humans fed a normal sodium diet, all published data have shown that the aldosterone response to corticotropin infusion [24] or to acute ACTH injection [26][27][28] is not significantly altered in the elderly. Furthermore, the only previous study of in vivo aldosterone response to ACTH in the rat was that of Magdich and Frolkis [7,29] in male Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in Plasma Corticosterone and Aldosterone Responses to Exogenous ACTH in the Rat

Ait-Chaoui¹,

Rakotondrazafy²,

Brudieux³

1995

Horm Res

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Age related changes in the time courses of response of plasma corticosterone and aldosterone to exogenously applied ACTH were simultaneously studied in old (female and male) Long-Evans rats and compared to both young and adult pentobarbitone-anesthetized and dexamethasone-pretreated control rats. Acute intravenous injection of either 0.5 or 50.0 ng ACTH (1-24)/100 g body weight increased plasma concentrations of the two steroids with a similar time course in all groups of rats. However, we observed a significant age-related attenuation in the plasma corticosteroid response. Thus, in old as compared to young rats there was a decrease of approximately 45, 40 and 30% in plasma corticosterone levels respectively 8 min after the lower dose of ACTH in female and 45 min after the higher dose in female and male rats. Similarly, an attenuated (approximately -38%) response of plasma aldosterone levels, induced 45 min after the higher dose of ACTH, was observed both in old female and male rats. These results suggest that the previously reported age-related decreases of in vivo corticosterone and aldosterone secretion are, at least in part, due to a reduced capacity of adrenocortical cells for steroid biosynthesis and release in response to stimulation by ACTH.

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“…The secretions of cortisol and adrenal androgens are mainly regulated by ACTH, however, the production of adre nal androgens may be influenced by cortical androgen stimulating factor (CASH), a pos sible pituitary factor [10]. We reported that the response of plasma adrenal androgens to ACTH in elderly individuals was remarkably reduced compared with that in the young individuals, whereas the secretory capacity of cortisol in response to ACTH was well maintained in the aged [7], We suggested the presence of a selective alteration in adrenal androgen secretion in aged subjects [4,7], In the present study, we examined whether the human pituitary-adrenal axis exhibits agerelated changes in response to o-CRF and whether o-CRF-induced secretions of this adrenal androgen is mediated by ACTH and/or other factors.…”

Section: Introductionmentioning

confidence: 99%

Aging Is without Effect on the Pituitary-Adrenal Axis in Men

Ohashi¹,

Fujio²,

Kato³

et al. 1986

Gerontology

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The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations, in all subjects. Moreover, there were no significant differences in the time-dependent responses of plasma ACTH, cortisol and DHEA to o-CRF between the young and elderly male individuals o-CRF showed no significant rise of plasma DHEA-S, in all subjects. We conclude that the pituitary-adrenal sensitivity to the hypothalamic CRF in the elderly does not change with aging.

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Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

Cited by 70 publications

References 8 publications

Evidence for Age-Related Change in Plasma 19-Hydroxyandrostenedione.

Evidence for Age-Related Change in Plasma 19-Hydroxyandrostenedione.

Age-Related Changes in Plasma Corticosterone and Aldosterone Responses to Exogenous ACTH in the Rat

Aging Is without Effect on the Pituitary-Adrenal Axis in Men

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