Adrenocortical Tumors (Act) in Children: Relationship Between Disease Stage and Outcome

Sandrini, Romolo; Lacerda, Luiz de; Sampaio, Gilberto Antunes; Sabbaga, Cesar Cavalli; Schmit-Lobe, M C; Roberson, Paula K.; Cat, Izrail; Ribeiro, Raul C.

doi:10.1203/00006450-199305001-00111

Cited by 5 publications

(6 citation statements)

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“…The extent of disease was retrospectively defined as localized or advanced on the basis of a modified staging system proposed previously (Table 1) [5,8]. Assignment to the localized disease (stage I or II) category required complete tumor resection and no evidence of disease elsewhere.…”

Section: Eligibility Criteria and Data Collectionmentioning

confidence: 99%

Clinical and Outcome Characteristics of Children With Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Michalkiewicz

Sandrini

Figueiredo

et al. 2004

JCO

455

506

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Section: Eligibility Criteria and Data Collectionmentioning

confidence: 99%

Clinical and Outcome Characteristics of Children With Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Michalkiewicz

Sandrini

Figueiredo

et al. 2004

JCO

455

506

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“…Several staging systems have been proposed, of which the modified Sandrini staging system is the most popular. [2][3][4] Michalkiewitz et al reported on the overall prognosis of childhood ACC based on an international registry and showed that the prognosis of this disease is related to tumor stage. 4 They reported a 5-year event-free survival rate of 72.8% for stage I/II ACC, whereas patients with stage III/IV disease had a 5-year event-free survival rate of approximately 20%.…”

Section: Discussionmentioning

confidence: 99%

“…Acquired etiologies of MAS include neurofibromatosis, fibromuscular dysplasia, retroperitoneal fibrosis, mucopolysaccharidosis, Williams syndrome, and giant cell arteritis, including Takayasu disease and temporal (cranial) arteritis. 3 Therapies for MAS include medical treatment, surgery, and endovascular treatment. 3 Treatment of MAS should be individualized and depends on patient age, size, degree of renal artery stenosis, and concomitant medical problems.…”

Section: Introductionmentioning

confidence: 99%

“…3 Therapies for MAS include medical treatment, surgery, and endovascular treatment. 3 Treatment of MAS should be individualized and depends on patient age, size, degree of renal artery stenosis, and concomitant medical problems. 1 Previous studies have reported MAS as a disease of late childhood or early adulthood, 4,5 but more recently, a lower age at diagnosis has been reported (mean age, 4.5 years).…”

Section: Introductionmentioning

confidence: 99%

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Contralateral pleural recurrence of adrenocortical carcinoma after surgical resection

Inage¹,

Saito²,

Saito³

et al. 2011

Pediatrics International

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HHT can be used as salvage treatment for CML patients who acquire the T315I BCR-ABL mutation. 7 Chemotherapy consisting of daunorubicin, HHT and cytosine arabinoside induced CR in this patient, we added imatinib mesylate afterwards. This combination of drugs maintained complete hematological and cytogenetic remission for 31 months; and no severe side effects was observed in this case.In further studies, the effects of combination use of imatinib mesylate and HHT should be investigated to improve treatment results of Ph(+) AML. Our patient achieved molecular remission shortly after imatinib mesylate plus HHT-based antitumor chemotherapy and has long-term remission on maintenance therapy with imatinib, sustained for at least 31 months. To the best of our knowledge this is the longest reported survival of a child with de novo BCR-ABL-positive AML. Our results suggest that imatinib mesylate combined with HHT-based chemotherapy is very useful for treating childhood Ph(+) AML.Key words adrenocortical carcinoma, familial cancer, functional tumor, mitotane, pleural recurrence.Adrenocortical carcinoma (ACC) in children is rare and constitutes about 0.2% of childhood cancers. There is a strong relationship between ACC and some hereditary cancers, especially Li-Fraumeni syndrome. Most cases of ACC are endocrinologically active tumors, and include hormonal symptoms such as Correspondence: Eisuke Inage, MD,

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“…Hypertension may be seen in up to 43% cases [5]. The following staging criteria can be adopted for ACT [6]: Stage I : Tumour totally excised, tumour volume <200 cm 3 , absence of metastasis, normal hormone levels after surgery. Stage II : Microscopic residual tumour, tumour >200 cm 3 , tumour spillage during surgery or persistence of abnormal hormone levels after surgery.…”

Section: Functional Adrenocortical Tumour In Youngmentioning

confidence: 99%

Functional Adrenocortical Tumour in Young

Prasad¹

2010

Medical Journal Armed Forces India

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Adrenocortical Tumors (Act) in Children: Relationship Between Disease Stage and Outcome

Cited by 5 publications

References 0 publications

Clinical and Outcome Characteristics of Children With Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Clinical and Outcome Characteristics of Children With Adrenocortical Tumors: A Report From the International Pediatric Adrenocortical Tumor Registry

Contralateral pleural recurrence of adrenocortical carcinoma after surgical resection

Functional Adrenocortical Tumour in Young

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