Adrenocorticotropin and Calcitonin in Medullary Thyroid Carcinoma: Frequency of Occurrence and Localization in the Same Cell Type by Immunocytochemistry*

Goltzman, David; Huang, Shao Nan; Browne, Christopher; Solomon, Samuel

doi:10.1210/jcem-49-3-364

Cited by 43 publications

(5 citation statements)

References 23 publications

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“…'~-~~ Recently, evidence that two hormones, calcitonin and ACTH, can appear in the same tumor cells in medullary carcinoma of the thyroid has also appeared. 18 Patient 1 in this report developed the ACTH syndrome at a time when the tumor had significantly regressed and SIADH had clinically disappeared on combination chemotherapy. Given the above cited evidence for heterogeneity of tumor cell populations, it is possible that the combination chemotherapy was successful in eradicating a population of cells that produced ADH but that another group of cells, which had the capacity to produce biologically active ACTH, persisted or emerged.…”

Section: Discussionmentioning

confidence: 66%

Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung—assessment of clinical implications in patients on combination chemotherapy

Abeloff

Trump

Baylin

1981

Cancer

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Small cell carcinoma of the lung is the tumor most commonly associated with ectopic ACTH production and hypercortisolism. The relationship between this paraneoplastic endocrine syndrome and the clinical course of the tumor is examined in this review of patients with the ectopic ACTH syndrome and small cell carcinoma seen at The Johns Hopkins Oncology Center between 1973 and 1979. Five of 157 (3.2%) patients with small cell carcinoma were clinically diagnosed as having the ectopic ACTH syndrome. The onset of this endocrine syndrome appeared to coincide with a more aggressive phase of the course of small cell carcinoma. Further analysis of these cases suggests that the development of the ectopic ACTH syndrome may reflect changes in cell populations within the tumor and/or alterations in tumor behavior with time and perhaps with the effects of drug therapy.

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Section: Discussionmentioning

confidence: 66%

Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung—assessment of clinical implications in patients on combination chemotherapy

Abeloff

Trump

Baylin

1981

Cancer

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“…Medullary carcinoma may show a variable histological appearance and trabecular, glandular and papillary patterns have been described (Freeman & Lindsay 1965, Williams, Brown & Doniach 1966, Goltzman et al 1979, Harach & Williams 1983, Kakudo et al 1979). In addition, amyloid deposition, originally considered as important for its diagnosis is no longer regarded as essential (Hedinger, Williams & Sobin 1988).…”

Section: Discussionmentioning

confidence: 99%

Hyalinizing trabecular adenoma of the thyroid. A report of three cases with immunohistochemical and ultrastructural studies

1989

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We have studied three examples of benign thyroid tumours which conform to the lesion recently described as hyalinizing trabecular adenoma. The prominent feature of this trabecular epithelial lesion is the extracellular deposition of an eosinophilic material that does not show the features of amyloid; the epithelial cells may be elongated, sometimes radially arranged around the eosinophilic material. All three tumours showed positive immunocytochemical staining for thyroglobulin, keratin, chromogranin and neuron-specific enolase. One tumour showed isolated cells with immunoreactivity for somatostatin, argyrophil cytoplasmic granularity with the Grimelius technique, and ultrastructurally demonstrable cytoplasmic electron-dense endocrine granules. The hyaline extracellular material in all three tumours showed strong immunoreactivity for both type IV collagen and laminin. Previous radiation may be important in the causation of this tumour, and it shows a frequent association with severe thyroiditis. We conclude that the main histological feature of this lesion, the hyaline material, is due to the overproduction of a basement membrane-like material by the neoplastic follicular cells. The presence in one tumour of evidence of endocrine differentiation may reflect the potential for follicular cells to show biphasic differentiation, a feature which may be more frequent than has been previously recognized. Several of the other features of this tumour--for example the frequent intranuclear cytoplasmic inclusions--may lead to diagnostic problems, and the entity deserves wider recognition.

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“…I n addition we were unable to confirm the presence of ACTH-immunoreactivity and calcitonin-immunoreactivity in the same cells of the medullary carcinoma of the thyroid of Patient 7. 32 It has been shown that tumors may secrete large precursor molecules ("big" hormones) or other, most often, biologically inactive fragment^.^^,^^ On the basis of our findings we cannot decide if the substances produced by the tumors were identical, or if they were similar in chemical structure and biologic activity and cross-reacting immunologically with antisera produced against physiologically secreted hormones.…”

Section: Vol 48mentioning

confidence: 79%

Ectopic hormone production by endocrine tumors: Localization of hormones at the cellular level by immunocytochemistry

Heitz

Klöppel

Polak

et al. 1981

Cancer

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Clinical and laboratory data, histologic, electron microscopic and immunocytochemical findings of the tumors of eight patients suffering from Cushing's syndrome and of one patient with hypercalcemia are described. The unlabeled antibody enzyme method was used for the detection of insulin, glucagon, somatostatin, pancreatic polypeptide, corticotropin, beta-lipotropin, calcitonin, parathyroid hormone, and gastrin. Ectopic Cushing's syndrome was caused by pancreatic endocrine tumors, medullary thyroid carcinoma, a bronchial, a gastric and a thymic carcinoid, and a carcinoid of the mediastinum. Hypercalcemia in one patient was related to a pancreatic endocrine tumor. After surgery the clinical symptoms disappeared in two patients, but persisted or relapsed in five patients. ACTH-immunoreactivity could be demonstrated in six of eight tumors; calcitonin-immunoreactivity was found in the tumor of the patient suffering from hypercalcemia. ACTH-immunoreactivity could be localized to secretory granules by immunoelectron microscopy, and the presence of ACTH and beta-LPH in the same tumor cells could be shown in one pancreatic tumor. A combination of production of orthotopic and ectopic hormones was found in one, and secretion of two ectopic hormones was detected in another pancreatic endocrine tumor.

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Adrenocorticotropin and Calcitonin in Medullary Thyroid Carcinoma: Frequency of Occurrence and Localization in the Same Cell Type by Immunocytochemistry*

Cited by 43 publications

References 23 publications

Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung—assessment of clinical implications in patients on combination chemotherapy

Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung—assessment of clinical implications in patients on combination chemotherapy

Hyalinizing trabecular adenoma of the thyroid. A report of three cases with immunohistochemical and ultrastructural studies

Ectopic hormone production by endocrine tumors: Localization of hormones at the cellular level by immunocytochemistry

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