Adrenomedullin—A New Marker in Febrile Neutropenia: Comparison With CRP and Procalcitonin

Demirkaya, Metin; Tuğcu, Deniz; Akçay, Arzu; Aydoğan, Gönül; Akıcı, Ferhan; Salcioglu, Zafer; Ekmekçi, Hakan; Sevinir, Betül; Ekmekçi, Özlem Balcı

doi:10.3109/08880018.2015.1057310

Cited by 19 publications

(13 citation statements)

References 25 publications

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“…ADM showed a stronger correlation as severity predictor than the other two tested biomarkers, CRP and PCT. (62) In adults, ADM has been extensively studied not only in sepsis but also in specific infections such as severe community-acquired pneumonia. (63,64) …”

Section: Introductionmentioning

confidence: 99%

Use of biomarkers in pediatric sepsis: literature review

Lanziotti

Póvoa

Soares

et al. 2016

Revista Brasileira De Terapia Intensiva

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Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

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Section: Introductionmentioning

confidence: 99%

Use of biomarkers in pediatric sepsis: literature review

Lanziotti

Póvoa

Soares

et al. 2016

Revista Brasileira De Terapia Intensiva

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“…PCT levels were significantly higher in the sepsis group than those in the CDI group at admission, day 3, and days 7 -10. In the sepsis group, PCT levels on days 7 -10 days were significantly higher than those in the sepsis group (4). PCT values from the deceased patients on days 7 -10 were significantly higher than those from patients who survived.…”

Section: Contextmentioning

confidence: 82%

“…First, in his study, adrenomedullin was used as a biomarker in the febrile neutropenia episodes of children with cancer. Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection (4).…”

Section: Contextmentioning

confidence: 99%

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Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

Frieri¹,

Kumar²,

Boutin³

2016

J Pediatr Rev

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Context: There is a logical connection with biomarkers, trauma, and sepsis. This review paper provides new information and clinical practice implications. Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Stress management both in trauma is based upon the notion that stress causes an immune imbalance in susceptible individuals. Evidence Acquisition: Data sources included studies indexed in PubMed, a meta-analysis, predictive values, research strategies, and quality assessments. A recent paper by one of the authors stated marked increase in serum procalcitonin during the course of a septic process often indicates an exacerbation of the illness, and a decreasing level is a sign of improvement. A review of epidemiologic studies on pediatric soccer patients was also addressed. Keywords for searching included biomarkers, immunity, trauma, and sepsis. Results: Of 50 reviewed articles, 34 eligible articles were selected including biomarkers, predictive values for procalcitonin, identifying children at risk for intra-abdominal injuries, blunt trauma, and epidemiology, a meta-analysis. Of neonatal associated sepsis, the NF-kappa B pathway by inflammatory stimuli in human neutrophils, predictive value of gelsolin for the outcomes of preterm neonates, a metaanalysis interleukin-8 for neonatal sepsis diagnosis. Conclusions: Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms, and physiological functions of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Various topics were covered such as biomarkers, trauma, sepsis, inflammation, innate immunity, role of neutrophils and IL-8, reactive oxygen species, neonatal hypoxia, NF-kappa B related to inflammation. These topics are clearly linked and are very important for pediatricians, pulmonologists, and immunologists in academic centers and in practice.

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“…Numerous studies reported the applicability of ADM as a biomarker in cardiovascular diseases, including the prognosis of future cardiovascular events in high-risk patients or the clinical outcomes after acute heart failure and myocardial infarction [191][192][193]. In addition, ADM levels can be used as a risk marker for ischemic stroke, for the prediction of short-term mortality in community-acquired pneumonia and sepsis, as an indicator for ectopic pregnancy or febrile neutropenia and for the prognosis of cancer progress [189,[194][195][196][197][198].…”

Section: Cancermentioning

confidence: 99%

Adrenomedullin – new perspectives of a potent peptide hormone

Schönauer

Els‐Heindl

Beck‐Sickinger

2017

Journal of Peptide Science

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Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the calcitonin gene-related peptide (CGRP) superfamily of vasoactive peptide hormones. ADM exhibits a significant vasodilatory potential and plays a key role in various regulatory mechanisms, predominantly in the cardiovascular and lymphatic system. It exerts its effects by activation of the calcitonin receptor-like receptor associated with one of the receptor activity-modifying proteins 2 or 3. ADM was first isolated from human phaeochromocytoma in 1993. Numerous studies revealed a widespread distribution in various tissues and organs, which is reflected by its multiple physiological roles in health and disease. Because of its anti-inflammatory, anti-apoptotic and proliferative properties, ADM exhibits potent protective functions under diverse pathological conditions, but it is also critically involved in tumor progression. ADM has therefore raised great interest in therapeutic applications and several clinical trials already revealed promising results. However, because the receptor activation mode has not yet been fully elucidated, a rational design of potent and selective ligands is still challenging. Detailed information on the binding mode of ADM from a recently reported crystal structure as well as efforts to improve its plasma stability and bioavailability may help to overcome these limitations in the future. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

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Adrenomedullin—A New Marker in Febrile Neutropenia: Comparison With CRP and Procalcitonin

Cited by 19 publications

References 25 publications

Use of biomarkers in pediatric sepsis: literature review

Use of biomarkers in pediatric sepsis: literature review

Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

Adrenomedullin – new perspectives of a potent peptide hormone

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