Adrenomedullin and galanin responses to orthostasis in older persons

Broadbent, James C.; Reichmuth, Johannes; Trozić, Irhad; Kneihsl, Markus; Rössler, Andreas; Green, David A.; Rodríguez, Joel S; Hinghofer‐Szalkay, Helmut; Fazekas, Franz; Goswami, Nandu

doi:10.1111/eci.12803

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…A systematic review by Heinrich et al ( 2010 ) indicates that 0.85–1.5% of all health care costs are dedicated solely to the consequences of falls. Therefore, understanding the mechanisms that contribute to falls as well as how risk of falls and falls-related injuries can be reduced is an important aspect in geriatric healthcare delivery (Blain et al, 2016 ; Bousquet et al, 2017 ; Broadbent et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Orthostatic Intolerance in Older Persons: Etiology and Countermeasures

et al. 2017

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Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population. This review examines current scientific knowledge regarding orthostatic intolerance and how it comes about and provides a framework for understanding of (patho-) physiological concepts of cardiovascular (in-) stability in ambulatory and bedrest confined senior citizens as well as in individuals with disease conditions [e.g., orthostatic intolerance in patients with diabetes mellitus, multiple sclerosis, Parkinson's, spinal cord injury (SCI)] or those on multiple medications (polypharmacy). Understanding these aspects, along with cardio-postural interactions, is particularly important as blood pressure destabilization leading to orthostatic intolerance affects 3–4% of the general population, and in 4 out of 10 cases the exact cause remains elusive. Reviewed also are countermeasures to orthostatic intolerance such as exercise, water drinking, mental arithmetic, cognitive training, and respiration training in SCI patients. We speculate that optimally applied countermeasures such as mental challenge maintain sympathetic activity, and improve venous return, stroke volume, and consequently, blood pressure during upright standing. Finally, this paper emphasizes the importance of an active life style in old age and why early re-mobilization following bedrest confinement or bedrest is crucial in preventing orthostatic intolerance, falls and falls-related injuries in older persons.

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Section: Introductionmentioning

confidence: 99%

Orthostatic Intolerance in Older Persons: Etiology and Countermeasures

et al. 2017

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“…X 53 Adrenomedullin and galanin concentrations were similar between genders and did not change following adoption of the standing posture. To further clarify the roles, these hormones play in orthostatic intolerance, adrenomedullin and galanin concentrations should be assessed in participants who show presyncopal symptoms during an orthostatic challenge.…”

Section: Bmentioning

confidence: 93%

Research update for articles published in EJCI in 2017

Arellano-Orden

Bacopoulou

Băicuș

et al. 2019

Eur J Clin Investigation

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“…The evidence that has accumulated in the meanwhile weakens this statement. We recently investigated hormonal responses (adrenomedullin and galanin) during a sit-to-stand protocol in older males and females [96]. We observed that adrenomedullin and galanin levels were similar between gender and did not change during standing.…”

Section: Involvement Of Leucocyte/endothelial Cell Interactions In Anmentioning

confidence: 94%