Adrenomedullin and total nitrite levels in children with Henoch-Sch�nlein purpura

İşlek, İsmail; Balat, Ayşe; Çekmen, Mustafa; Yürekli, Muhittin; Muslu, Ali; Şahinöz, Saime; Sivaslı, Ercan

doi:10.1007/s00467-003-1193-2

Cited by 16 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adrenomedullin levels in childhood have been studied in Bartter syndrome [7], Henoch-Schönlein purpura [8] and primary nocturnal enuresis [9]. However, there is only one study in the literature on urinary tract infections (UTI), which is one of the major health problems in childhood.…”

Section: Introductionmentioning

confidence: 99%

Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux

et al. 2005

View full text Add to dashboard Cite

Adrenomedullin (AM) is a strong vasodilator peptide with proven antimitogenic and antiproliferative effects in renal mesangial cells, as well as diuretic and natriuretic actions. Its gene expression is stimulated by endotoxins (lipopolysacharides) and cytokines. Consequently, its plasma and urinary levels are known to deviate from normal levels in many renal diseases. The purpose of this study is to determine plasma and urinary AM levels in children with renal parenchymal scar (RPS) and vesicoureteral reflux (VUR). The study was carried out on 74 children with recurrent urinary tract infections, arranged in groups: 25 patients with RPS with VUR (group I), 16 patients with RPS without VUR (group II), 12 patients with VUR without RPS (group III) and 21 healthy children as the control group. Plasma and urinary AM concentrations were both determined by high performance liquid chromotography (HPLC). Plasma AM was measured as picomoles per milliliter (pM/ml) and urinary AM as pM/mg urinary creatinine. In addition, serum creatinine, creatinine clearance and fractional sodium excretion (FE(Na)) were measured. All cases with RPS and VUR had normal blood pressure levels. The plasma AM levels were higher, although not significantly, in the control group (56.2+/-14.0 pM/ml) than in group I (50.6+/-4.2 pM/ml), group II (49.6+/-3.7 pM/ml) and group III (50.6+/-3.6 pM/ml) ( P =0.162). The urinary AM levels were higher in the control group (80.1+/-33.9 pM/mg) than in the three study groups (52+/-7.6 pM/mg, 58.6+/-7.5 pM/mg and 44.2+/-6.4 pM/mg; P =0.003, P =0.002 and P =0.002, respectively). There were no differences among the 4 groups (group I, group II, group III and the control group) in terms of FE(Na) and creatinine clearance ( P >0.05 and P >0.05, respectively). The finding that diminished urinary AM levels in patients with RPS and VUR implies that AM can be a prognostic factor in the long-term follow-up of cases with these diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Activation of coagulation cascade including hyperfibrinolysis, increased thrombomodulin, tissue plasminogen activator, and plasminogen activator inhibitor levels and decreased factor XIII levels have been reported in HSP [46][47][48]. Increased nitric oxide, adrenomedullin, and endothelin levels, impaired vascular endothelium-dependent relaxation, and increased apoptosis have also been shown in patients with HSP [49][50][51][52][53][54]. However none of these findings has yet been confirmed to have a causal relationship in HSP rather than being the result of vascular damage.…”

Section: Pathogenesismentioning

confidence: 99%

Henoch Schonlein Purpura in Childhood

Öner¹,

Demircin

2005

CPR

View full text Add to dashboard Cite

Henoch Schönlein purpura (HSP) is one of the most common vasculitis in childhood characterized by nonthrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Depending on the anatomical sites of involvement many other manifestations including every other organ of the body can be seen. However the most important involvement determining the longterm prognosis is the severity of renal disease. The pathogenesis of HSP is not clear, but it is believed to be an immunoglobulin-mediated inflammatory process resulting from immune complex reaction to various antigenic stimuli. Although none of them has been confirmed to be the exact cause, many bacterial, viral and parasitic infections, insect bites, vaccinations, and exposure to drug and dietary allergens have been described as triggering factors for HSP. Immune complexes are deposited in the vascular walls and mesangium triggering the mediators of inflammation. Treatment of HSP is supportive, and a clear advantage of glucocorticoids over supportive therapy has not been shown in the management of the disease except rapidly progressive type of glomerulonephritis. In this article the epidemiological, clinical and pathogenetic features, current treatment strategies, and outcome of the disease will be reviewed.

show abstract

“…Henoch-Schönlein purpura (HSP) is one of the most common types of multisystemic vasculitis seen in childhood and characterized by non-thrombocytopenic, non-blanching purpura, arthritis, abdominal pain, and renal involvement (1). The epidemiology of HSP is obscure and in the literature there are different values of incidence of this disease.…”

mentioning

confidence: 99%

A case of scrotal swelling mimicking testicular torsion preceding Henoch-Schönlein vasculitis

Akgün¹

2012

BLL

View full text Add to dashboard Cite

Henoch-Schönlein purpura, is one of the most common types of multisystemic vasculitis seen in childhood. The major clinical manifestations are cutaneous purpura, arthritis, abdominal pain, gastrointestinal bleeding, and nephritis. Isolated central nervous system vasculitis, seizures, coma and hemorrhage, Guillan--Barré syndrome, ataxia and central and peripheral neuropathy, ocular involvement, orchitis, epididymitis or testicular torsion are medical or surgical complications. In this study, we report a 7-year-old boy with scrotal swelling mimicking testicular torsion with ultrasonographic and clinical fi ndings that the typical clinical features of Henoch-Schönlein purpura including rashes and arthritis were developed after one week of surgery (Ref. 15) Henoch-Schönlein purpura (HSP) is one of the most common types of multisystemic vasculitis seen in childhood and characterized by non-thrombocytopenic, non-blanching purpura, arthritis, abdominal pain, and renal involvement (1). The epidemiology of HSP is obscure and in the literature there are different values of incidence of this disease. An incidence of 13.5 cases per 100,000 children per year was observed by Stewart M. et al. whereas 0.2-10 cases per 100,000 were reported by Farley et al (2, 3). Although the major clinical manifestations are cutaneous purpura, arthritis, abdominal pain, gastrointestinal bleeding, and nephritis, other manifestations include an isolated central nervous system vasculitis, seizures, coma and hemorrhage, Guillan-Barré syndrome, ataxia and central and peripheral neuropathy, ocular involvement, orchitis, epididymitis or testicular torsion are other medical or surgical conditions that can be seen with HSP (4). The present report details a case of a young Turkish boy with scrotal swelling mimicking testicular torsion with ultrasonographic fi ndings and with the typical clinical features of HSP developed one week after the surgery. Case reportA 7-year-old boy was brought to emergency department with complaints of scrotal swelling and pain lasting 1 day. Except a history of brucellosis 2 years ago, the personal and family histories were unremarkable. Moreover, recent history of infectious disease or trauma was not described. At the time of admission, there were left scrotal edema and testicular pain and he had no rash in any part of the body. The laboratory investigations revealed hemoglobin 13.1 g/dl, white blood cell count 13000/μL and platelet count 462,000/μL. Serum electrolytes, liver enzymes, blood coagulation tests, antinuclear antibody, rheumatoid factor, antistreptolysin O, serum IgA level and urinalysis were within normal levels. On ultrasonographic examination decreased blood fl ow and enlarged testis were seen. Surgical exploration revealed a hematocele, with bloody fl uid accumulation mainly in the tunica vaginalis testis and an edematous, hyperemic testis and epydidymis without torsion of both of them. Edema of testis and epydidymis resolved after surgery. The patient was discharged without any complication on t...

show abstract

Adrenomedullin and total nitrite levels in children with Henoch-Sch�nlein purpura

Cited by 16 publications

References 31 publications

Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux

Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux

Henoch Schonlein Purpura in Childhood

A case of scrotal swelling mimicking testicular torsion preceding Henoch-Schönlein vasculitis

Contact Info

Product

Resources

About