2006
DOI: 10.1038/sj.bjp.0706698
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Adrenomedullin in the rostral ventrolateral medulla inhibits baroreflex control of heart rate: a role for protein kinase A

Abstract: 1 The rostral ventrolateral medulla (RVLM) is an essential vasomotor center in the brainstem which participates in maintaining resting levels of arterial pressure and for regulating baroreflex activity. We have demonstrated that microinjections of adrenomedullin (ADM), a vasoactive neuropeptide, into the RVLM cause increased resting mean arterial pressure (MAP) and heart rate (HR). However, the effect of ADM on baroreflex function remains unclear. 2 The purposes of the present study were to investigate the eff… Show more

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Cited by 16 publications
(12 citation statements)
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“…The pressor effect evoked by H-89 in the RVLM confirm what has been previously noted (Xu and Krukoff, 2006). ZD 7288, which blocks HCN channels but is ineffective alone in the RVLM, as described previously (Miyawaki et al, 2003), contributed to inhibitory effects when preceded by other drugs.…”
Section: Discussionsupporting
confidence: 89%
“…The pressor effect evoked by H-89 in the RVLM confirm what has been previously noted (Xu and Krukoff, 2006). ZD 7288, which blocks HCN channels but is ineffective alone in the RVLM, as described previously (Miyawaki et al, 2003), contributed to inhibitory effects when preceded by other drugs.…”
Section: Discussionsupporting
confidence: 89%
“…As adrenomedullin is a vasodilator, this might buffer sympathetic actions and dampen baroreflex-driven responses (Xu and Krukoff 2006) as they occur with central hypovolemia caused by HUT, the cardiovascular stimulus in our study. Our results further suggest that with increased supine epinephrine levels (epinephrine infusion clamping systolic arterial pressure at 120% control level), supine cardiac performance rises to a level otherwise reached by head up tilting, while adrenomedullin is still elevated with HUT.…”
Section: Discussionmentioning
confidence: 93%
“…This we believe is important as many of the observed hemodynamic effects during increased sympathetic activity [e.g., during passive head up tilt (HUT)] and simultaneous epinephrine administration might be associated with changes in adrenomedullin activity. Adrenomedullin, a potent peptide with a half-life of about 20 min (Meeran et al 1997), plays a central role in fine-tuning of humoral responses provoked by different physiological stimuli (Haditsch et al 2007;Ishimitsu et al 2006), triggers adrenal catecholamine release and may buffer the sympathetic response to hypotension and thereby dampens baroreflex-driven reactions (Xu and Krukoff 2006).…”
Section: Introductionmentioning
confidence: 99%
“…We have demonstrated that microinjections of ADM, a vasoactive neuropeptide, into the RVLM cause increased resting mean arterial pressure and heart rate), and inhibited baroreflex control of heart rate [51,52].…”
Section: Functions Of Admmentioning
confidence: 99%