2011
DOI: 10.1016/j.pbb.2011.06.015
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Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats

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Cited by 39 publications
(16 citation statements)
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“…In this study, treatment with the combination of doxorubicin and cyclophosphamide was found to decrease the [23,30]. These reports suggest that the anxiety-like behavior induced by doxorubicin is associated with oxidative stress and reduced total antioxidant capacity [30].…”
Section: Discussionsupporting
confidence: 61%
“…In this study, treatment with the combination of doxorubicin and cyclophosphamide was found to decrease the [23,30]. These reports suggest that the anxiety-like behavior induced by doxorubicin is associated with oxidative stress and reduced total antioxidant capacity [30].…”
Section: Discussionsupporting
confidence: 61%
“…Acute administration of adriamycin, an effective anti-cancer chemotherapy drug used in humans, increased anxiety-like behavior was showed, and impaired the locomotor and exploratory activities in male rats, when compared to controls. Additionally, drug-treated animals revealed an increased glutathione-S-transferase activity and MDA levels, while brain glutathione concentration decreased, when compared to controls [38]. …”
Section: Anxiety and Oxidative Stress In Animal Modelsmentioning
confidence: 99%
“…Doxorubicin (DOX; Adriamycin) is an anthracycline antibiotic commonly used as chemotherapy of solid tumors, especially for treating breast and esophageal carcinomas . However, it has been noted that long‐term use of DOX tends to induce neurotoxicity and may cause neuropsychiatric diseases including depression and impaired cognition function . Previous studies of patients undergoing chemotherapy for breast cancer have consistently shown their depressed mood and decreased interest in surroundings, which highlight the importance of further understanding the neurotoxic effects of DOX and seeking potential therapeutic strategies.…”
Section: Introductionmentioning
confidence: 99%