Adropin – a circulating factor in metabolic control or a drop in the ocean?

Gao, Su; Stevens, Joseph R.; Butler, Alice

doi:10.1080/17446651.2016.1175938

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Plasma adropin concentrations are related to indices of hepatic lipid metabolism in nonhuman primates and humans (31,(53)(54)(55)(56). Adropin is a secreted peptide that has insulin-sensitizing actions in mouse models of insulin resistance (35)(36)(37)(38)(39)(40)(41)(42).…”

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confidence: 99%

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi

Butler

Graham

Stanhope

et al. 2020

Journal of Lipid Research

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Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques. Plasma ANGPTL3 concentrations increased ∼30% to 40% after 1 and 3 months of a high-fructose diet (both P < 0.001 vs. baseline). During fructose-induced metabolic dysregulation, plasma ANGPTL3 concentrations were positively correlated with circulating indices of insulin resistance [assessed with fasting insulin and the homeostatic model assessment of insulin resistance (HOMA-IR)], hypertriglyceridemia, adiposity (assessed as leptin), and systemic inflammation [C-reactive peptide (CRP)] and negatively correlated with plasma levels of the insulin-sensitizing hormone adropin. Multiple regression analyses identified a strong association between circulating APOC3 and ANGPTL3 concentrations. Higher baseline plasma levels of both ANGPTL3 and APOC3 were associated with an increased risk for fructose-induced insulin resistance. Fish oil previously shown to prevent insulin resistance and hypertriglyceridemia in this model prevented increases of ANGPTL3 without affecting systemic inflammation (increased plasma CRP and interleukin-6 concentrations). ANGPTL3 RNAi lowered plasma concentrations of ANGPTL3, triglycerides (TGs), VLDL-C, APOC3, and APOE. These decreases were consistent with a reduced risk of atherosclerosis. In summary, dietary sugar-induced increases of circulating ANGPTL3 concentrations after metabolic dysregulation correlated positively with leptin levels, HOMA-IR, and dyslipidemia. Targeting ANGPTL3 expression with RNAi inhibited dyslipidemia by lowering plasma TGs, VLDL-C, APOC3, and APOE levels in rhesus macaques.

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confidence: 99%

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi

Butler

Graham

Stanhope

et al. 2020

Journal of Lipid Research

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“…This is consistent with reports of adropin's involvement in preventing insulin resistance and impaired glucose tolerance. [ 42 ] In the VegGI study, a time and meal‐dependent postprandial decrease in plasma adropin was observed. These results agree with Stevens et al., (2016), who reported significant meal effects of adropin and a decrease over time compared to baseline following a mixed meal containing 60% energy as carbohydrate.…”

Section: Discussionmentioning

confidence: 99%

Inter‐Individual Variation in Postprandial Glycemic Responses in Women Co‐Ingesting Green Leafy Vegetables with a Carbohydrate Meal: Interactions with the Sirtuin System

Sayegh

Henderson

Farquharson

et al. 2021

Molecular Nutrition Food Res

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Scope: Green leafy vegetables (GLV) may improve postprandial glycemic responses (PGR) and metabolic health. However, inter-individual variations (IIV) preclude conclusive evidence. Sirtuin system is emerging as a key player in blood glucose control. This study investigates IIV in PGR in women co-ingesting GLV with a carbohydrate meal and interactions with the sirtuin system. Methods and Results: Volunteers (n = 31 women) consume rice, rice with bok choy, or spinach (75g available carbohydrate) on separate occasions. Postprandial glucose, insulin, adropin, and lipid levels are measured. Anthropometric measurements and sex hormones are measured. GeXP assay measures whole blood postprandial gene expression profiles of 25 markers involved in sirtuin signaling. GLV consumption has no significant effect on PGR, which shows high variation. PGR correlated with age, but no other consistent associations are observed. Sirtuin gene expression profiles reveal distinct stratified subgroups associated with PGR, lipid, insulin, fat mass, waist/hip circumferences, and adropin levels. Conclusion: PGR to co-ingesting GLV with a carbohydrate meal are highly variable in this cohort and fail to reveal a significant reduction in PGR. Variable responses are largely independent of menopausal status and meal consumed. However, lower expression of sirtuin gene targets is associated with higher PGR and with markers linked to health status.

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“…Animal studies demonstrated improved glucose homeostasis, fatty liver, and dyslipidemia after adropin infusion, which indicates its potential role in therapy. Moreover, the level of adropin in animal studies was associated with the amount of fat intake, indicating that its expression is regulated by feeding and suppressed by fasting [ 33 , 65 , 66 ]. Adropin presumably inhibits fat oxidation by suppressing the expression and activity of carnitine palmitoyltransferase-1b [ 66 ].…”

Section: Adropinmentioning

confidence: 99%

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

Močnik

Varda

2022

Children

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Cardiovascular diseases are the leading cause of morbidity and mortality in the modern world. Their common denominator is atherosclerosis, a process beginning in childhood. In pediatrics, the aim of preventive measures is to recognize children and adolescents at risk for accelerated atherosclerosis and possible premature cardiovascular events in adulthood. Several diagnostic procedures and biomarkers are available for cardiovascular risk assessment in adults. However, reliable markers in pediatrics are still insufficiently studied. In this contribution, we discuss five potential biomarkers of particular interest: kidney injury molecule-1, salusin-α and -β, uromodulin, and adropin. Studies regarding the pediatric population are scarce, but they support the evidence from studies in the adult population. These markers might entail both a prognostic and a therapeutic interest.

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Adropin – a circulating factor in metabolic control or a drop in the ocean?

Cited by 5 publications

References 26 publications

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi

Inter‐Individual Variation in Postprandial Glycemic Responses in Women Co‐Ingesting Green Leafy Vegetables with a Carbohydrate Meal: Interactions with the Sirtuin System

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

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