Adropin and glucagon-like peptide-2 are associated with glucose metabolism in obese children

Chen, Rui-Min; Yuan, Xin; Ouyang, Qi; Lin, Xiaoqin; Ai, Zhuanzhuan; Zhang, Ying; Yang, Xiaohong

doi:10.1007/s12519-019-00296-6

Cited by 13 publications

(9 citation statements)

References 17 publications

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“…In contrast, in mice with high-fat diet-induced obesity, serum adropin levels are low (<1 ng/mL). An inverse correlation of adropin levels and body mass index (BMI) was also confirmed by human studies [4,[12][13][14][15][16][17]], suggesting that a low level of adropin is a hallmark of obesity. Nevertheless, a recent detailed study showed that this association should be interpreted cautiously.…”

Section: Modulation Of Adropin By Body Mass Index (Bmi) Diet and DImentioning

confidence: 76%

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating Enho as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer.

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Section: Modulation Of Adropin By Body Mass Index (Bmi) Diet and DImentioning

confidence: 76%

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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“…Our previous research found that serum adropin level was associated with serum insulin level and homeostasis model assessment of insulin resistance (HOMA-IR). Recent studies suggest that the gut microbiota can participate in the regulation of energy metabolism by regulating the levels of adipokines ( 18 ). This study determined the characteristics of gut microbiota in obese Chinese children and adolescents with/without IR, and analyzed the association between gut microbiota and circulating cytokines which impact glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance

et al. 2021

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ObjectiveThe intestinal flora of gut microbiota in obese Chinese children and adolescents with and without insulin resistance (IR) was analyzed, as well as associations between the gut microbiota and two serum cytokines related to glucose metabolism, adropin and angiopoietin-like 4 (ANGPTL4).MethodsClinical data, fecal bacterial composition, glucose-related hormones, and serum adipokines (adropin and ANGPTL4) were analyzed in 65 Chinese children with exogenous obesity. The composition of the gut microbiota was determined by 16S rRNA-based metagenomics and IR was calculated using the homeostasis model assessment (HOMA).ResultsThe 65 obese subjects were divided into two groups: insulin sensitive (IS) (n=40, 57.5% males) or IR (n=25, 60% males). Principal coordinates analysis revealed that the gut microbiota samples from the IS group clustered together and separated partly from the IR group (p=0.008). By Mann-Whitney U-test, at a phylum level, a reduction of Firmicutes and an increase of Bacteroidetes in the IR subjects was observed. LEfSe analysis revealed that IS subject, when compared to their IR counterparts, harbored members of the order Coriobacteriales, Turicibacterales, Pasteurellales and family Turicibacteraceae, that were significantly more abundant. In contrast, the IR subjects had members of family Peptococcaceae that were significantly more prevalent than the IS subjects (all p<0.05). Spearman’s correlation analysis revealed that serum ANGPTL4 was positively associated with genus Bacteroides, Butyricimonas, and Alistipes, and adropin was positively associated with genus Anaerostipes and Alistipes, and negatively associated with genus Blautia (all p<0.05).ConclusionIn obese children, the gut microbiome in IR subjects was significantly discordant from the IS subjects, and the abundance of some metabolism-related bacteria correlated with the serum concentrations of adropin and ANGPTL4. These observations infer that the gut microbiota may be involved in the regulation of glucose metabolism in obesity.

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“…ANGPTL4 de ciency in macrophages results in ER stress due to the cell-intrinsic reprogramming of fatty-acid metabolism [24]. ANGPTL4 has surfaced as principal regulators of plasma lipid metabolism by functioning as potent inhibitors of lipoprotein lipase in cardiovascular disease [25].…”

Section: Discussionmentioning

confidence: 99%

ANGPTL4 supports glutamine metabolism and promotes fatty acid oxidation in nonsmall cell lung cancer cells

Song

Nai-Dong²,

Yan³

et al. 2020

Preprint

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Background Angiopoietin-like proteins (ANGPTLs) 4 is key factor in the regulation of lipid and glucose metabolism in metabolic diseases. It also has been demonstrated highly expressed in cancers, but the regulation of energy metabolism on tumor remains to be determined.Methods Two different NSCLC cells A549 and H1299 were used to investigate the role of ANGPTLs 4 in energy metabolism by tracer technique and seahorse XF technology in ANGPTLs4 knockdown cell. RNA microarray and specific inhibitors were used in identification targets in overexpression ANGPTLs4 cells.Results Knockdown ANGPTLs4 could inhibit the energy metabolism and proliferation of NSCLC cells. Knockdown ANGPTLs4 had no significant effect on glycolysis, but affected the glutamine consumption and fatty acid oxidation. Knockdown ANGPTLs4 also significantly inhibited the growth of metastasis and energy metabolism of tumor in mice, but had a weak effect on glycolysis. RNA microarray analysis showed that ANGPTLs4 significantly affected GLS and CPT1. ANGPTLs4 overexpression cells exposed to glutamine deprivation, the effect on cell proliferation and energy metabolism were significantly decreased, but still has difference compared with normal NSCLC cells. ANGPTLs4 overexpression cells treated with GLS and CPT1 inhibitor at the same time, the regulatory effects on cell proliferation and energy metabolism were disappeared.Conclusions ANGPTLs4 could promote the glutamine consumption and fatty acid oxidation, but not glycolysis, and accelerated the energy metabolism in NSCLC.

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Adropin and glucagon-like peptide-2 are associated with glucose metabolism in obese children

Cited by 13 publications

References 17 publications

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance

ANGPTL4 supports glutamine metabolism and promotes fatty acid oxidation in nonsmall cell lung cancer cells

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