ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A

Zhao, Shu; Liu, Yue; Wang, Jian; Wen, Yi; Wu, Baitong; Yang, Danjing; Wang, Guangming; Xiu, Guanghui; Ling, Bin; Du, Dajiang; Xu, Jun

doi:10.1016/j.intimp.2023.110390

Cited by 3 publications

(1 citation statement)

References 56 publications

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“… 42 , 43 Mouse ADSCs are usually isolated from adipose tissue harvested from the inguinal region. 44 , 45 The enzymatic digestion method stands as the most frequently employed technique for isolating ADSCs. This process involves sequential steps, including tissue fragmentation, enzymatic digestion, filtration, centrifugation, and cultivation, for ADSC isolation.…”

Section: The Fundamental Characteristics Of Adsc-exosmentioning

confidence: 99%

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Wang,

Yang,

Zhang

et al. 2024

IJN

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Section: The Fundamental Characteristics Of Adsc-exosmentioning

confidence: 99%

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Wang,

Yang,

Zhang

et al. 2024

IJN

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WITHDRAWN: The dysregulated autophagy in osteoarthritis: Revisiting molecular profile

Liu,

Wang,

liu

et al. 2024

Progress in Biophysics and Molecular Biology

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Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis

Li,

et al. 2024

Front. Cell Dev. Biol.

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Osteoarthritis (OA) is the most common type of arthritis characterized by progressive cartilage degradation, with its pathogenesis closely related to chondrocyte autophagy. Chondrocytes are the only cells in articular cartilage, and the function of chondrocytes plays a vital role in maintaining articular cartilage homeostasis. Autophagy, an intracellular degradation system that regulates energy metabolism in cells, plays an incredibly important role in OA. During the early stages of OA, autophagy is enhanced in chondrocytes, acting as an adaptive mechanism to protect them from various environmental changes. However, with the progress of OA, chondrocyte autophagy gradually decreases, leading to the accumulation of damaged organelles and macromolecules within the cell, prompting chondrocyte apoptosis. Numerous studies have shown that cartilage degradation is influenced by the senescence and apoptosis of chondrocytes, which are associated with reduced autophagy. The relationship between autophagy, senescence, and apoptosis is complex. While autophagy is generally believed to inhibit cellular senescence and apoptosis to promote cell survival, recent studies have shown that some proteins are degraded by selective autophagy, leading to the secretion of the senescence-associated secretory phenotype (SASP) or increased SA-β-Gal activity in senescent cells within the damaged region of human OA cartilage. Autophagy activation may lead to different outcomes depending on the timing, duration, or type of its activation. Thus, our study explored the complex relationship between chondrocyte autophagy and OA, as well as the related regulatory molecules and signaling pathways, providing new insights for the future development of safe and effective drugs targeting chondrocyte autophagy to improve OA.

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ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A

Cited by 3 publications

References 56 publications

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

WITHDRAWN: The dysregulated autophagy in osteoarthritis: Revisiting molecular profile

Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis

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