Adsorption and Leachable Contamination of Flucloxacillin, Cyclosporin and Amiodarone Following Delivery Through an Intravenous Administration Set

Abstract

Drug/administration set interactions may modify pharmaceuticals during delivery. In this study, only 90% of the amiodarone was delivered through a generic administration set. Given the growing use of generic administration sets in hospital settings, validation of the suitability of their use is required to ensure patient safety and expected levels of efficacy.

Understanding and Characterizing the Drug Sorption to PVC and PE Materials

“…A loss of isosorbide dinitrate, tacrolimus, diazepam, amiodarone, insulin has been observed during infusions via PVC tubings. [2][3][4][5][6][7][8][9] These losses of API by sorption can require an adjustment of the dose administered, based on the expected biological effect of the drug. Sometimes, rinsing the tubing by the drug before its administration is a possible way to limit these interactions.…”

“…Sorption (including the adsorption of a drug to the polymer surface, absorption into the polymer matrix, and permeation) can affect the efficacy and result in the loss of an important component, such as an active pharmaceutical ingredient (API) − or an excipient . This can lead to ineffective or variable drug responses after the administration of injectable drugs, and makes it difficult to control the concentration of the delivered drug.…”

“…This can lead to ineffective or variable drug responses after the administration of injectable drugs, and makes it difficult to control the concentration of the delivered drug. A loss of isosorbide dinitrate, tacrolimus, diazepam, amiodarone, and insulin has been observed during infusions via PVC tubings. − These losses of API by sorption can require an adjustment of the dose administered, based on the expected biological effect of the drug. Sometimes, rinsing the tubing with the drug before its administration is a possible way to limit these interactions.…”

Insulin Adsorption onto PE and PVC Tubings

“…[5][6][7][8] A loss of isosorbide dinitrate, tacrolimus, diazepam, amiodarone, insulin has been observed during infusions via PVC tubings. 1,3,[8][9][10][11][12][13] These losses of API by sorption can require an adjustment of the dose administered, based on the expected biological effect of the drug. Flushing the tubing with the infused drug before its administration is a possible way to limit these interactions.…”