2023
DOI: 10.1021/acs.jpcb.3c02487
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Adsorption and Self-Aggregation of Chiral [5]-Aza[6]helicenes on DNA Architecture: A Molecular Dynamics Study

Giuseppina Raffaini

Abstract: Helicenes are an extremely interesting class of conjugated molecules without asymmetric carbon atoms but with intrinsic chirality. These molecules can interact with double-stranded chiral B-DNA architecture, modifying after their adsorption the hydrophilicity exposed by DNA to the biological environment. They also form ordered structures due to self-aggregation processes with possible different light emissions. Following initial studies based on molecular mechanics (MM) and molecular dynamics (MD) simulations … Show more

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“…All these theoretical results agree with the experimental data [92][93][94][95]. Possible new classes of hydrophobic drug carriers that can adsorb on the chiral DNA structure are currently being studied [99,100]. Interestingly, using MM/MD methods, the possible slower or faster release of drugs adhered and dispersed in nano aggregates or on a solid silica surface for their solubilization may be related to the strength of intermolecular interaction [95,98] as in the present work.…”
Section: Introductionsupporting
confidence: 85%
“…All these theoretical results agree with the experimental data [92][93][94][95]. Possible new classes of hydrophobic drug carriers that can adsorb on the chiral DNA structure are currently being studied [99,100]. Interestingly, using MM/MD methods, the possible slower or faster release of drugs adhered and dispersed in nano aggregates or on a solid silica surface for their solubilization may be related to the strength of intermolecular interaction [95,98] as in the present work.…”
Section: Introductionsupporting
confidence: 85%