2016
DOI: 10.1142/s1793292016500387
|View full text |Cite
|
Sign up to set email alerts
|

Adsorption and Self-Assembly of Anticancer Antibiotic Doxorubicin on Single-Walled Carbon Nanotubes

Abstract: We performed a combined experimental and theoretical study of the conjugates obtained from single-walled carbon nanotubes and anticancer antibiotic doxorubicin (DOX). Atomic force microscopy (AFM) imaging at lower magnification revealed, extended regions of single-walled carbon nanotubes (SWNTS) fully covered with DOX adsorbed molecules, along with some bare parts without the adsorbed drug, thus suggesting that the DOX adsorption is a cooperative process. Ambient atmosphere scanning tunneling microscopy (STM) … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
19
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 21 publications
(19 citation statements)
references
References 38 publications
0
19
0
Order By: Relevance
“…[25] We interpret them as the conductive tricyclic dihydroxyanthraquinone subunit in Dox, which is hold by π-π interactions on the benzene rings of the CNT. In contrast to Rodriguez-Galvan, [16] we interpret the arrangement of the tricyclic aromatic system as parallel to the CNT axis. Probably the less crowded side of Dox is interacting with the CNT and the sugar moiety is pointing away from the CNT (Figure 2a′,f).…”
Section: Structure Of Dox@cntmentioning
confidence: 75%
See 4 more Smart Citations
“…[25] We interpret them as the conductive tricyclic dihydroxyanthraquinone subunit in Dox, which is hold by π-π interactions on the benzene rings of the CNT. In contrast to Rodriguez-Galvan, [16] we interpret the arrangement of the tricyclic aromatic system as parallel to the CNT axis. Probably the less crowded side of Dox is interacting with the CNT and the sugar moiety is pointing away from the CNT (Figure 2a′,f).…”
Section: Structure Of Dox@cntmentioning
confidence: 75%
“…[3,14] The supramolecular Dox@CNT complex is reasonably stable, has been characterized by many methods, e.g., UV-vis, [3,5,9] Raman, [1] FTIR, [12] and zeta potential, [7,9] and exhibits a large drug loading efficiency, of 70-130%, as measured by UV-vis. [1] Recently, scanning tunneling microscopy (STM) results with molecularly resolved Dox physically adsorbed on CNT have been reported, [16] showing Dox on the cylindrical CNT surface in a helical arrangement with a 50° inclination of Dox with respect to the CNT axis. [5] Transmission electron microscopy (TEM) measurements on the self-assembled systems [7,9,14] show Dox as clusters on CNT, [14] and adsorbed at the interstitial space of helically wrapping polymers, [7,9] as further supported by atomic force microscopy (AFM) [1,3] and (scanning electron microscopy) SEM studies.…”
mentioning
confidence: 99%
See 3 more Smart Citations