Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid

Tucker, I.; Burley, A.; Petkova, R.E.; Hosking, Sarah; Penfold, J.; Thomas, Robert K.; Li, Peixun; Webster, John R. P.; Welbourn, Rebecca J. L.; Doutch, James

doi:10.1016/j.jcis.2021.03.101

Cited by 53 publications

(29 citation statements)

References 51 publications

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“…21,26 Additionally, GA is a natural sweetener, and its sweetness is 30 times that of glucose. 32 As already mentioned, GA has broad application prospects in the food industry. Whey proteins are viewed as a kind of high-quality proteins owing to their nutritional and functional properties.…”

Section: Introductionmentioning

confidence: 95%

“…Importantly, GA is also proven to be relatively safe unless consumed in large quantities during application . Meanwhile, a range of studies have been reported about the absorption behavior of GA in aqueous solution owing to its distinctive structure . GA is also used as a foam/bubble stabilizer in food processing, such as beer and soft drinks, due to its surface activity. , Additionally, GA is a natural sweetener, and its sweetness is 30 times that of glucose .…”

Section: Introductionmentioning

confidence: 99%

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pH-Dependent Binding Behavior of the α-Lactalbumin/Glycyrrhizic Acid Complex in Relation to Their Foaming Characteristics in Bulk

Shi

Liu

et al. 2022

J. Agric. Food Chem.

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This work aimed to understand the relationships of the interaction mechanism and foaming characteristics of αlactalbumin (α-La) and glycyrrhizic acid (GA) after acidic (pH 2.5) and neutral (pH 7.0) treatment. The critical aggregation concentration (CAC) of GA in the presence of α-La was 0.6 mM at pH 7.0, while it was 1.0 mM at pH 2.5. Also, in the presence of a GA concentration of 0−15.00 mM, more GA molecules combined onto the α-La surface at pH 2.5 than at pH 7.0, as evident from the binding isotherms. The turbidity and particle size of α-La/GA were greater in acidic solution than those under neutral conditions. This result could be interpreted by the formation of aggregates under higher GA concentration at pH 2.5. Meanwhile, the viscosity of the complex was higher at pH 2.5 than at pH 7.0 in the presence of 3.00−15.00 mM GA, as analyzed from the rheological properties. The foaming ability (FA) of α-La was significantly enhanced in the presence of 10.00 mM GA. Simultaneously, acidic solution could generate a more stable foaming system with a thicker film layer stabilized by the complex compared with neutral solution. These findings could be beneficial for developing a kind of acidic food-grade foaming agent.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

pH-Dependent Binding Behavior of the α-Lactalbumin/Glycyrrhizic Acid Complex in Relation to Their Foaming Characteristics in Bulk

Shi

Liu

et al. 2022

J. Agric. Food Chem.

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“…Next, spherical micelles were observed in the GA aqueous solution with modest anisotropy. 40 The addition of metal ions affected the minimal micelle growth. In addition, Zhao et al 41 found GA formed an injectable low-molecular-weight hydrogel with nanocluster morphology in the aqueous solution.…”

Section: Glycyrrhizic Acidmentioning

confidence: 99%

Self-assembled Natural Product-based Carrier-free Nanoplatforms for Efficient Bioactivity

Xu¹,

Xu²,

Wang³

et al. 2022

J Explor Res Pharmacol

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Natural products featured by an abundant molecule skeleton and structural complexity exhibit extensive pharmacological or biological activities. Thus, natural active ingredients are an important source of drug research and development. However, the inherent defects, including low solubility, low bioavailability, and unacceptable off-target toxicity, affect their development into clinical drugs. Recently, carrier-free supermolecule nanodrugs have attracted considerable attention. These nanodrugs are self-assembled by pure drugs mainly through hydrophobicity, hydrogen bond, π-π stacking, and electrostatic interaction, which possess a high drug loading capability, enhanced water solubility of the drugs, and synergistic therapeutic efficacy. In this review, natural product-based carrier-free nanoplatforms with self-assembly for efficient bioactivity were examined. These self-assembled natural products included triterpenoids, alkaloids, flavonoids, and anthraquinones. Moreover, the morphology of the formed nanoplatforms could be a nanosphere, nanofiber, nanorod, or fibrillar network, and they could exhibit several bioactivities, such as antitumor, anti-inflammatory, immunoregulation, and liver protection. Briefly, we analyzed the types and sources, formation mechanism, biological activity, and mode of action of the nanomedicine, and discussed the future of this field. We believe this review would provide a landscape of natural product-based carrier-free nanoplatforms.

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“…Glycyrrhizic acid is a saponin component extracted from the traditional Chinese medicine licorice [ 9 , 10 ]. Glycyrrhizic acid has anti-inflammatory, immunomodulatory, anticoagulant and steroid-like effects and is widely used in clinical practice [ 11 , 12 ]. Studies have found that glycyrrhizic acid has an inhibitory effect on P450 enzymes, so it can be inferred that glycyrrhizic acid combined with hydrocortisone can reduce the inactivation of glucocorticoids in the liver and enhance its bioavailability [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome

Zhao

Xiang

et al. 2021

J Nanobiotechnol

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Clinically, steroid-resistant nephrotic syndrome (SRNS) is always prolonged and difficult to treat and easily develops into end-stage renal disease, resulting in a low survival rate. Strategies to reverse steroid resistance and reduce the long-term use of high doses of steroid medicines are urgently needed. In this study, a novel nanoparticle drug system (Pm-GCH) with a core–shell structure was designed. Metal–organic frameworks, synthesized by glycyrrhizic acid (G) and calcium ions (Ca2+) loaded with hydrocortisone (H) were the core of the nanoparticles. Platelet membrane vesicles were the shells. The natural platelet membrane endows Pm-GCH with good biocompatibility and the ability to promote immune escape. In addition, under the chemotaxis of inflammatory factors, platelet membranes assist Pm-GCH in nonspecific targeting of the inflammatory sites of the kidney. Under an inflammatory acid environment, GCH slowly degrades and releases glycyrrhizic acid and hydrocortisone. Glycyrrhizic acid inhibits the inactivation of hydrocortisone, jointly inhibits the activity of phospholipase A2 (PLA2) and the classic activation pathway of complement C2, blocks the production of inflammatory factors, plays an anti-inflammatory role, and enhances the efficacy of hydrocortisone in the treatment of SRNS. Moreover, glycyrrhizic acid alleviates osteoporosis induced by long-term use of glucocorticoids. These results indicate that Pm-GCH is a promising treatment strategy for SRNS. Graphical Abstract

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Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid

Cited by 53 publications

References 51 publications

pH-Dependent Binding Behavior of the α-Lactalbumin/Glycyrrhizic Acid Complex in Relation to Their Foaming Characteristics in Bulk

pH-Dependent Binding Behavior of the α-Lactalbumin/Glycyrrhizic Acid Complex in Relation to Their Foaming Characteristics in Bulk

Self-assembled Natural Product-based Carrier-free Nanoplatforms for Efficient Bioactivity

A novel biomimetic nanomedicine system with anti-inflammatory and anti-osteoporosis effects improves the therapy efficacy of steroid-resistant nephrotic syndrome

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