Adsorption and thermal release of highly volatile compounds in silica aerogels

Gorle, B. S. K.; Смирнова, Ирина; McHugh, Mark A.

doi:10.1016/j.supflu.2008.09.010

Cited by 50 publications

(26 citation statements)

References 14 publications

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“…Freeze drying and supercritical drying preempt capillary effects and leaves large pore sizes ranging from 10 to 30 nm. As a result, the drug release rate from critical dried silica with large pores is much faster than from conventionally dried xerogels [85][86][87].…”

Section: Pore Parametermentioning

confidence: 99%

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

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Section: Pore Parametermentioning

confidence: 99%

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

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“…Because of their high porosity, aerogels can also be utilized for this purpose. Menthol was used as a model compound and adsorbed onto silica aerogels and the thermal stability of the composite demonstrated [16]. The corresponding mass loss of menthol from various formulations upon heating (sublimation) is shown in Figure 31.14.…”

Section: Thermal Release Of Active Compounds From Silica Aerogelsmentioning

confidence: 99%

“…Hence, aerogel carriers could find application in the pharmaceutical and food industry for stabilization, retention, and/or release of flavour compounds during thermal treatment. Further, the thermally triggered release of an adsorbate-loaded aerogel might be useful as temperature sensor [16].…”

Section: Thermal Release Of Active Compounds From Silica Aerogelsmentioning

confidence: 99%

“…The precipitation of various organic substances ranging from polar to nonpolar (1-menthol, 2-methoxy pyrazine, naphthalene, benzoic acid, octacosane, dodecane, and ibuprofen) inside the pores of silica aerogels having different physical and surface properties was investigated [9,12,16]. Supercritical CO 2 was again used as a solvent since high supersaturation rates are needed to initiate the precipitation, which can be achieved by a rapid depressurization.…”

Section: Crystallization/precipitation Of Drugs In Aerogelsmentioning

confidence: 99%

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Pharmaceutical Applications of Aerogels

Смирнова

2011

Aerogels Handbook

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At present, an interest has grown in the field of biocompatible aerogels and composite aerogel materials in life science, especially in biomedical and pharmaceutical applications. Due to their large surface area, open pore structure, and biocompatibility, aerogels are very promising candidates for drug delivery systems. The use of both inorganic and organic aerogels as carriers for pharmaceutically active compounds is discussed in this chapter. Both the stability and the release kinetics of the drug can be significantly improved by loading them into aerogels. First attempts to prepare semisolid and solid pharmaceutical formulations have been made. Furthermore, aerogels can be used as a host matrix for bioactive compounds (enzymes and proteins), which improve or enable their performance. Taking into account all research activities in the area of aerogels, a number of promising pharmaceutical applications can be expected in future. IntroductionSilica aerogels were used in daily life products since 1960s, when Monsanto's aerogels were introduced as additives for cosmetics and toothpaste. At present, an interest has grown in the field of biocompatible aerogels and composite aerogel materials in life sciences, especially for biomedical and pharmaceutical applications. In principle, biocompatible aerogels can be made from any organic compound, whose properties such as toxicity and biodegradation are suitable for the given application. In the case of aerogel composites, the final material consists of an aerogel matrix and one or more additional phases (of any composition or scale), which influence the properties of the final product. Thus, at least one phase has a physical structure with dimensions in the order of nanometres (the particles and pores of the aerogel). The aerogel composites can be prepared in two different ways: through the addition of a target compound during the sol-gel process (Figure 31.1A) and by post-treatment of the dried aerogels (Figure 31.1B), for example, by adsorption, vapour phase deposition, or reactive gas treatment.The first method (a) is attractive by its simplicity and flexibility, since virtually every material can be easily added to the sol solution before gelation. This added material can be of I. Smirnova

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“…Supercritical carbon dioxide, sc-CO 2 , one of the most usable supercritical fluids, is capable of dissolving many organic and organometallic compounds and introducing them into porous materials and also through sorption procedure into nonporous substances that founds an application for the modification of polymers [1][2][3][4]. Application of the supercritical carbon dioxide in organometallic chemistry, mostly as a reaction medium, has been pioneered by Polyakoff and co-workers [5].…”

Section: Introductionmentioning

confidence: 99%