Adsorption Behavior of Bone Morphogenetic Protein-2 on a Graphite Substrate for Biomedical Applications

Marquetti, Izabele; Desai, Salil

doi:10.3844/ajeassp.2018.1037.1044

Cited by 18 publications

(18 citation statements)

References 20 publications

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“…Different studies have conducted in vivo studies of a fabricated MN to deliver drugs and vaccines. However, an upcoming challenge is the fabrication of a MN that has the ability to deliver macromolecules with high molecular weights and high hydrophilicity [ 69 , 231 , 232 , 233 ]. Other issues associated with using a MN for drug delivery are irritation, skin allergy, and redness [ 16 ].…”

Section: Gaps In Research and Future Outlookmentioning

confidence: 99%

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

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Drug delivery through the skin offers many advantages such as avoidance of hepatic first-pass metabolism, maintenance of steady plasma concentration, safety, and compliance over oral or parenteral pathways. However, the biggest challenge for transdermal delivery is that only a limited number of potent drugs with ideal physicochemical properties can passively diffuse and intercellularly permeate through skin barriers and achieve therapeutic concentration by this route. Significant efforts have been made toward the development of approaches to enhance transdermal permeation of the drugs. Among them, microneedles represent one of the microscale physical enhancement methods that greatly expand the spectrum of drugs for transdermal and intradermal delivery. Microneedles typically measure 0.1–1 mm in length. In this review, microneedle materials, fabrication routes, characterization techniques, and applications for transdermal delivery are discussed. A variety of materials such as silicon, stainless steel, and polymers have been used to fabricate solid, coated, hollow, or dissolvable microneedles. Their implications for transdermal drug delivery have been discussed extensively. However, there remain challenges with sustained delivery, efficacy, cost-effective fabrication, and large-scale manufacturing. This review discusses different modes of characterization and the gaps in manufacturing technologies associated with microneedles. This review also discusses their potential impact on drug delivery, vaccine delivery, disease diagnostic, and cosmetics applications.

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Section: Gaps In Research and Future Outlookmentioning

confidence: 99%

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

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“…http: //www.ijmp.jor.br v. 11, n. 1, January-February 2020ISSN: 2236 It primarily filters the blood that comes from the organs of the digestive tract, which is the main entry point of toxins in the body, but in fact the liver fills all the blood in the body, retaining and metabolizing substances harmful to the body (AVERSA et al, 2018a;AVERSA et al, 2018b;AVERSA et al, 2017a;AVERSA et al, 2017b;AVERSA et al, 2016a;AVERSA et al, 2016b;AVERSA et al, 2016c;AVERSA et al, 2016d;AVERSA et al, 2016e;AVERSA et al, 2016f;AVERSA et al, 2016g;AVERSA et al, 2016h;AVERSA et al, 2016i;AVERSA et al, 2016j;AVERSA et al, 2016k;AVERSA et al, 2016l;AVERSA et al, 2016m;AVERSA et al, 2016n;ALJOHANI;ALEXANDER;WANG, 2018;APICELLA et al, 2018 a-c;MARQUETTI;ARMAH, 2018;WILK et al, 2017;BABAEV et al,…”

Section: Independent Journal Of Management and Production (Ijmandp)mentioning

confidence: 99%

Some aspects related to the human body plant

Petrescu¹,

Petrescu²

2020

Ind. Jour. Manag. & Prod.

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The paper presents some important aspects related to the human liver, which is a real human body's plant, having essential roles in human life, especially in the preparation of the food necessary for the organism, in the production of the various essential substances necessary for the body and the basic chemical elements. At the same time, the human liver has the role of detoxifying the body, processing and eliminating toxic elements from ingested foods. The liver secretes various substances necessary for the human body. The more we keep this vital organ healthier, the more human body becomes free, healthier, younger and vigorous. The liver is probably the organ with the most diverse functions in the human body. After ingestion of food, they are processed along the digestive tract and degraded to nutrients that will reach all tissues and organs in the body. The liver is an annexe of the digestive tract with a very complex structure. The morphological unit of the liver is the liver lobe. It has a pyramid shape and a length of a few millimeters. The liver contains up to 100,000 lobules.

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“…Antioxidants will reduce, thus, the radicals so dangerous for the body because of their power of oxidation very high. Thus, antioxidants from food, protects the organic molecules, for example fats or DNA, of oxidation and appear to play a role safeguards against carcinogenicity (AVERSA et al, 2018a;AVERSA et al, 2018b;AVERSA et al, 2017a;AVERSA et al, 2017b;AVERSA et al, 2016a;AVERSA et al, 2016b;AVERSA et al, 2016c;AVERSA et al, 2016d;AVERSA et al, 2016e;AVERSA et al, 2016f;AVERSA et al, 2016g;AVERSA et al, 2016h;AVERSA et al, 2016i;AVERSA et al, 2016j;AVERSA et al, 2016k;AVERSA et al, 2016l;AVERSA et al, 2016m;AVERSA et al, 2016n;ALJOHANI;ALEXANDER;WANG, 2018;APICELLA et al, 2018a;APICELLA et al, 2018b;APICELLA et al, 2018c;MARQUETTI;;…”

Section: Independent Journal Of Management and Production (Ijmandp)mentioning

confidence: 99%

New natural antioxidants

Petrescu¹,

Petrescu²,

Buzea

2020

Ind. Jour. Manag. & Prod.

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Antioxidants are, no doubt, an essential part of an optimal health and even traditional doctors support the importance of an appropriate contribution of antioxidants taken through food. Antioxidants are a category of molecules able to inhibit the oxidation of other molecules. The body distributes various nutrients in the body due to their antioxidant properties and also factory antioxidant enzymes to keep under control the reaction in the chain of free radicals. Some antioxidants are produced by the body, but others don't. In addition, the body's natural ability to produce antioxidants decreases with age. Antioxidants play a significant role for health as it may influence the aging by fighting free radicals. There are antioxidants which can’t be produced in the human body, and to be taken through antioxidant-rich foods, or supplements powerful antioxidant. The paper aims to present some natural sources of oxidants that can be obtained through diet.

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Adsorption Behavior of Bone Morphogenetic Protein-2 on a Graphite Substrate for Biomedical Applications

Cited by 18 publications

References 20 publications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

Some aspects related to the human body plant

New natural antioxidants

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