Adsorption/desorption phenomena on pure and Teflon® AF‐coated titania surfaces studied by dynamic contact angle analysis

Rupp, Frank; Axmann, Detlef; Ziegler, Christiane; Geis-Gerstorfer, J

doi:10.1002/jbm.10198

Cited by 52 publications

(34 citation statements)

References 30 publications

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“…In this way, the contact angle could approach 0°, which greatly facilitates osteoblasts to spread on the treated surface [ 49 ]. But at the same time, some researchers believe that the chemical or plasma treatment yields satisfactory hydrophilicity that could not last for long in air [ 50 ].…”

Section: The Common Methods Of Surface Modifi Cationsmentioning

confidence: 99%

Effect of Titanium Surface Modifications of Dental Implants on Rapid Osseointegration

Lin

2016

Interface Oral Health Science 2016

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The initial cellular response to the dental implant is essential for the subsequent tissue regeneration around the foreign implant surface. There are many cells and proteins involved in the integration process which leads to the fi nal osseointegration between implants and peri-implant bone tissue. With regard to materials used in dental implants, titanium is a prevalent biomaterial applied in orthopedic or dental implants due to its premium mechanical and biological properties and osteoconductivity. The roughness and chemical composition of the titanium surface affect the process and rate of the osseointegration of dental implants. Different studies on the effect of roughness and wettability of titanium surface on the process of early events in the osseointegration are reviewed in this article. In addition, in order to accelerate this wound-healing process, varied surface topography and chemical composition have been produced depending on different types of surface modifi cations. The desirable dental implant surface design caters for the development of implantology for immediate loading and the improvement of long-term stability. An appropriate understanding of the interaction between cells and implant surfaces is essential for the future design of new surface which could enhance the speed and stability of osseointegration of dental implants.

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Section: The Common Methods Of Surface Modifi Cationsmentioning

confidence: 99%

Effect of Titanium Surface Modifications of Dental Implants on Rapid Osseointegration

Lin

2016

Interface Oral Health Science 2016

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“…DCA has been previously described in detail. 24,47 The chemical composition of the surfaces was examined by X-ray photoelectron spectroscopy (XPS, VG/SSI 2803 S-Probe, Kratos Analytical Ltd., Hofheim, Germany).…”

Section: Preparation and Characterization Of Ti Disksmentioning

confidence: 99%

High surface energy enhances cell response to titanium substrate microstructure

Zhao

Schwartz

Wieland

et al. 2005

J Biomedical Materials Res

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831

703

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Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase bone-to-implant contact and removal torque forces in vivo and induce osteoblast differentiation in vitro. Studies examining osteoblast response to controlled surface chemistries indicate that hydrophilic surfaces are osteogenic, but TiO2 surfaces produced until now exhibit low surface energy because of adsorbed hydrocarbons and carbonates from the ambient atmosphere or roughness induced hydrophobicity. Novel hydroxylated/hydrated Ti surfaces were used to retain high surface energy of TiO2. Osteoblasts grown on this modified surface exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1. Moreover, 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy. This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts.

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“…Differences in surface chemistry and energy can affect adsorption of serum proteins (29), including fibronectin (30), which can alter cell attachment (31,32). Microtopography also alters osteoblast attachment to a substrate (33), although surface chemistry may be a more critical variable for many materials (34).…”

mentioning

confidence: 99%

Integrin α2β1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates

Olivares-Navarrete

Raz

Zhao

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

215

182

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Efforts to improve bone response to biomaterials have focused on ligands that bind ␣5␤1 integrins. However, antibodies to ␣5␤1 reduce osteoblast proliferation but do not affect differentiation when cells are grown on titanium (Ti). ␤1-silencing blocks the differentiation stimulus of Ti microtopography, suggesting that other ␤1 partners are important. Stably ␣2-silenced MG63 human osteoblast-like cells were used to test whether ␣2␤1 specifically mediates osteoblast response to Ti surface micron-scale structure and energy. WT and ␣2-silenced MG63 cells were cultured on tissue culture polystyrene (TCPS) and Ti disks with different surface microtopographies: machined pretreatment (PT) surfaces [mean peak to valley roughness (R a) < 0.02 m], PT surfaces that were grit-blasted and acid-etched (SLA; R a ‫؍‬ 4 m), and SLA with high surface energy (modSLA). Alkaline phosphatase (ALP), ␣2 and ␤1 mRNA, but not ␣5, ␣v, ␤3, type-I collagen, or osteocalcin, increased on SLA and modSLA at 6 days. ␣2 increased at 8 days on TCPS and PT, but remained unchanged on SLA and modSLA. ␣2-protein was reduced 70% in ␣2-siRNA cells, whereas ␣5-mRNA and protein were unaffected. ␣2-knockdown blocked surface-dependent increases in ␤1 and osteocalcin and decreases in cell number and increases in ALP and local factors typical of MG63 cells grown on SLA and modSLA [e.g., prostaglandin E 2, osteoprotegerin, latent and active TGF-␤1, and stimulatory effects of 1␣,25(OH)2D3 on these parameters]. This finding indicates that ␣2␤1 signaling is required for osteoblastic differentiation caused by Ti microstructure and surface energy, suggesting that conclusions based on cell behavior on TCPS are not predictive of behavior on other substrates or the mechanisms involved.␣-2 integrin siRNA ͉ MG63 human osteoblasts ͉ titanium surface roughness T itanium (Ti) and Ti alloys are commonly used as biomaterials because their surface properties provide a biocompatible interface with peri-implant tissues. Strategies for modifying the nature of this interface frequently involve changes to the surface, thereby affecting protein adsorption, cell-substrate interactions, and tissue development (1). A common modification has been to create micron-scale and submicron scale roughness. Preclinical and clinical studies (2-12) show that these surfaces support greater bone-to-implant contact than smooth surfaces.How surface microstructure promotes an osteogenic response is an important question, because bone-forming osteoblasts preferentially colonize bone surfaces that have been preconditioned by bone-resorbing osteoclasts (13), resulting in complex micron-scale and submicron-scale morphologies (14). In vitro experiments using model surfaces indicate that migration, growth, and colony morphology of rat bone marrow cells (15) and osteoblasts (16-18) are sensitive to microstructure. These observations suggest that structural elements can modulate the spatial organization of cells and their ECM.The topography of osteoclast resorption pits in bone can be modeled by using Ti subs...

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Adsorption/desorption phenomena on pure and Teflon® AF‐coated titania surfaces studied by dynamic contact angle analysis

Cited by 52 publications

References 30 publications

Effect of Titanium Surface Modifications of Dental Implants on Rapid Osseointegration

Effect of Titanium Surface Modifications of Dental Implants on Rapid Osseointegration

High surface energy enhances cell response to titanium substrate microstructure

Integrin α2β1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates

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