Adsorption Equilibria of Rutin and Kaempferol-3-<i>O</i>-Rutinoside on CN-Bonded Silica from Supercritical Carbon Dioxide/Methanol

Lv, Huisheng; Yang, Shuyuan; Zhou, Jianqin; Zhang, Jia; Zhai, Ziwei; Geng, Zhongfeng

doi:10.1021/acs.jced.0c00345

Cited by 10 publications

(9 citation statements)

References 27 publications

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“…The two-component competitive Langmuir adsorption equilibrium isotherm model equation of rutin and K3R is shown as Equations ( 13) and ( 14) [36] :…”

Section: Tmb/smb Modelmentioning

confidence: 99%

“…For extract and raffinate nodes:

c_{ij} = c_{italicij + 1, 0}

For the desorbent node:

c_{ij} = \frac{v_{1}}{v_{4}} c_{italicij + 1, 0}

For the feed node:

c_{ij} = \frac{v_{3}}{v_{2}} c_{italicij + 1, 0} - \frac{v_{F}}{v_{2}} c_{i}^{F}

The two‐component competitive Langmuir adsorption equilibrium isotherm model equation of rutin and K3R is shown as Equations () and () [ 36 ] :

q_{A} = \frac{q_{mA} C_{A}}{1 + K_{A} C_{A} + K_{B} C_{B}}

q_{B} = \frac{q_{mB} C_{B}}{1 + K_{A} C_{A} + K_{B} C_{B}}

where

q_{A}

and

q_{B}

are the adsorption capacities of K3R and rutin, respectively. The parameters of

q_{mA}, q_{mB}

, K A , and K B are the same as those of the model of one‐component Langmuir adsorption isotherm.…”

Section: Theorymentioning

confidence: 99%

“…To determine the SMB process configuration and operating conditions, simulation was carried out based on the isotherm and kinetic parameters previously reported by our group. [ 36 ] According to the SFC chromatography experimental results, 318.15 K and 14 MPa were selected from temperature of 308.15–323.15 K and pressure of 8–16 MPa as the optimum technological conditions for the separation of rutin and K3R. The adsorption equilibrium data of rutin and kaempferol 3‐O‐rutoside were determined by the elution at characteristic point (ECP) method.…”

Section: Theorymentioning

confidence: 99%

“…The adsorption equilibrium data of rutin and kaempferol 3‐O‐rutoside were determined by the elution at characteristic point (ECP) method. [ 36 ] The diffusion coefficients of rutin and kaamphenol‐3‐O‐rutoside were determined by the chromatographic peak expansion method. [ 19 ] The isotherm and kinetic parameters in the optimum conditions obtained from experiments are shown in Table 1.…”

Section: Theorymentioning

confidence: 99%

“…Therefore, the model can be used to simulate the adsorptive processes of rutin and K3R corresponding to the extend Langmuir model in Aspen Chromatography. [ 36 ]…”

Section: Theorymentioning

confidence: 99%

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Purification of rutin by supercritical fluid simulated moving bed chromatography

Geng

Yang

et al. 2021

Can J Chem Eng

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Recent studies have shown that rutin (Quercetin‐3‐O‐rhamnosylglucoside) may have an inhibitory effect on COVID‐19. Rutin can be extracted from Tartary buckwheat as an active pharmaceutical ingredient. Nevertheless, its purification is mainly hindered by Kaempferol‐3‐O‐rutinoside (K3R) due to their similar molecular structures. This study intends to propose a simulated moving bed (SMB) chromatography process of rutin and K3R to achieve continuous production. True moving bed (TMB) and SMB models were established to numerically analyze and optimize this process. The system consists of a four‐zone SMB with two columns in each zone. The effects of the switch interval, feed flowrate, desorbent flowrate, extract flowrate, raffinate flowrate, and recycle flowrate on the purity and yield of rutin and K3R were investigated and the optimized conditions were chosen as 5 min, 3.5, 40, 34, 9.5, and 24.5 L/min, respectively. Consequently, the purities of 99.64% and 99.25%, and the yields of 99.81% and 99.37% for rutin and K3R were obtained, respectively. The simulation results can provide a guidance for the future industrial application of SF‐SMB to separate rutin and K3R.

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“…The two-component competitive Langmuir adsorption equilibrium isotherm model equation of rutin and K3R is shown as Equations ( 13) and ( 14) [36] :…”

Section: Tmb/smb Modelmentioning

confidence: 99%

“…For extract and raffinate nodes:

c_{ij} = c_{italicij + 1, 0}

For the desorbent node:

c_{ij} = \frac{v_{1}}{v_{4}} c_{italicij + 1, 0}

For the feed node:

c_{ij} = \frac{v_{3}}{v_{2}} c_{italicij + 1, 0} - \frac{v_{F}}{v_{2}} c_{i}^{F}

The two‐component competitive Langmuir adsorption equilibrium isotherm model equation of rutin and K3R is shown as Equations () and () [ 36 ] :

q_{A} = \frac{q_{mA} C_{A}}{1 + K_{A} C_{A} + K_{B} C_{B}}

q_{B} = \frac{q_{mB} C_{B}}{1 + K_{A} C_{A} + K_{B} C_{B}}

where

q_{A}

and

q_{B}

are the adsorption capacities of K3R and rutin, respectively. The parameters of

q_{mA}, q_{mB}

, K A , and K B are the same as those of the model of one‐component Langmuir adsorption isotherm.…”

Section: Theorymentioning

confidence: 99%

Section: Theorymentioning

confidence: 99%

Section: Theorymentioning

confidence: 99%

“…Therefore, the model can be used to simulate the adsorptive processes of rutin and K3R corresponding to the extend Langmuir model in Aspen Chromatography. [ 36 ]…”

Section: Theorymentioning

confidence: 99%

See 3 more Smart Citations