Adsorption kinetics of lysozyme on multi-walled carbon nanotubes and amino functionalized multi-walled carbon nanotubes from aqueous solution

Enayatpour, Behdad; Rajabi, Mostafa; Moradi, Omid; Asdolehzade, Neda; Nayak, Arunima; Agarwal, Shilpi; Gupta, Vinod Kumar

doi:10.1016/j.molliq.2018.01.079

Cited by 23 publications

(4 citation statements)

References 47 publications

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“…The value of the second rate constant of the adsorption process (k 2 ) 6.92 × 10 −5 g mg −1 min −1 obtained assuming the model of pseudo-second order proves that the process of adsorption is much faster than of DOX adsorption on the carrier modified by Wang [43] (3.52 × 10 −8 g mg −1 min −1 ), however, it is much slower than that of adsorption of lysozyme [65] or curcumin [55] on MWCNTs modified in different ways.…”

Section: Kinetic Model Parameters Valuesmentioning

confidence: 73%

Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Chudoba

Łudzik

Jażdżewska

et al. 2020

IJMS

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This study provides deep insight into the adsorption process of doxorubicin onto different types of carbon nanotubes that have been proved to show attractive properties as a drug delivery system. The main aim of the work was to propose probable adsorption mechanisms and interactions between the anticancer drug and surface of modified and pristine carbon nanotubes at blood pH. The carbon nanotubes were oxidized to optimize the absorbance efficiency relative to that of pristine multiwalled carbon nanotubes. The adsorption isotherm of the modified system was well described by the Temkin equation. It confirms that the adsorption in the system studied involves also hydrogen and covalent bonding and is exothermic in nature. The experimental kinetic curves of adsorption were fitted to different mathematical models to check if the kinetics of doxorubicin adsorption onto the modified multiwalled carbon nanotubes follows a pseudo-second-order model and the chemical sorption is bound to be the rate-limiting. On the basis of the molecular dynamics simulation, it was shown that in vacuo the aggregation tendency of doxorubicin molecules is far more favorable than their adsorption on pristine carbon nanotubes (CNTs). It suggests that only functionalization of the nanotube surface can affect the interaction between doxorubicin and functional groups of the carriers and increases the efficiency of the drug loading process.

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Section: Kinetic Model Parameters Valuesmentioning

confidence: 73%

Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Chudoba

Łudzik

Jażdżewska

et al. 2020

IJMS

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“…Therefore, understanding the adsorption process is critical to control, predict, and manipulate protein adsorption to design suitable membranes to yield intended applications. Protein adsorption has been thoroughly studied in the last two decades . Nevertheless, it is difficult to predict the interaction at the interfaces between proteins and polymeric particles for several reasons including the large size of proteins molecules compared to particles of the polymeric membrane.…”

Section: Introductionmentioning

confidence: 99%

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Sadegh

Sahay

Soni

2019

J of Applied Polymer Sci

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The adsorption of proteins onto polymeric surfaces is encountered in many natural and industrial processes and is a prerequisite to their efficient identification, separation, and purification by methods such as chromatography, and filtration. Nevertheless, the exact nature of the adsorption mechanisms and interfacial interactions is not easy to identify for a given protein-polymer system. Here, we aim to document the adsorption mechanism of a protein-polymer system by investigating the adsorption as well as desorption phenomenon of a protein [bovine serum albumin (BSA)] from the polymeric surface [polyethersulfone (PES)]. The analyses performed to document the adsorption mechanism of the BSA-PES system include scanning electron microscope (SEM), attenuated total reflection-Fourier transform infrared (FTIR), contact angle, zeta potential, surface charge density measurement, and Derjaguin-Landau-Verwey-Overbeek (DLVO). Here, SEM and FTIR identified the physical and chemical properties of pure PES and PES-BSA membranes. The low water contact angle of the PES-BSA membrane confirms its applicability for tissue engineering applications. Further, the zeta potential, surface charge density measurement, and DLVO analyses were performed to document the adsorption mechanism. The adsorption of BSA particles on the PES surface was carried out for pH values that ranged from 4 to 10 for contact times that ranged from 1 to 3 days. A monotonic increase in the zeta potential of the PES-BSA system indicated considerable adsorption of BSA particles on the PES surface. Further, BSA adsorption was very strong for pH values greater than 4.7 which confirms to strong electrostatic interactions between BSA and PES. The strong electrostatic interaction is also collaborated by low desorption rate, which was only 22% for pH 10 after 3 days of contact.

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“…Subsequently, the concentration of collected water (unbound peptides) ( C 1 ) was determined according to the standard curve at 238 nm by the microplate reader (Epoch 2, BioTek, USA). Last, the amount of peptide on 1 mg of MWNTs was calculated according to eq where C 0 are the concentrations of peptides at the initial time, and m is the mass of the MWNTs used. Measurements were repeated six times.…”

Section: Methodsmentioning

confidence: 99%

Terminal Group Modification of Carbon Nanotubes Determines Covalently Bound Osteogenic Peptide Performance

Wang

Cao

Zhao

et al. 2020

ACS Biomater. Sci. Eng.

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Osteogenic peptides are often introduced to improve biological activities and the osteogenic ability of artificial bone materials as an effective approach. Covalent bindings between the peptide and the host material can increase the molecular interactions and make the functionalized surface more stable. However, covalent bindings through different functional groups can bring different effects on the overall bioactivities. In this study, carboxyl and amino groups were respectively introduced onto carbon nanotubes, a nanoreinforcement for synthetic scaffold materials, which were subsequently covalently attached to the RGD/BMP-2 osteogenic peptide. MC3T3-E1 cells were cultured on scaffolds containing peptide-modified carbon nanotubes. The results showed that the peptide through the amino group binding could promote cell functions more effectively than those through carboxyl groups. The mechanism may be that the amino group could bring more positive charges to carbon nanotube surfaces, which further led to differences in the peptide conformation, protein adsorption, and targeting osteogenic effects. Our results provided an effective way of improving the bioactivities of artificial bone materials by chemically binding osteogenic peptides.

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Adsorption kinetics of lysozyme on multi-walled carbon nanotubes and amino functionalized multi-walled carbon nanotubes from aqueous solution

Cited by 23 publications

References 47 publications

Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Kinetic and Equilibrium Studies of Doxorubicin Adsorption onto Carbon Nanotubes

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Terminal Group Modification of Carbon Nanotubes Determines Covalently Bound Osteogenic Peptide Performance

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