Adsorption of 3‐ and 4‐benzoylpyridine on colloidal silver particles: a surface‐enhanced Raman scattering study

In this study, surface-enhanced Raman scattering (SERS) spectra of 6-propylthiouracil (6-PTU) on Au surface and the interaction between 6-PTU and human serum albumin (HSA) were studied. The Raman bands were assigned by the density functional theory calculations at the B3LYP/6-311++g(d,p) level. Furthermore, the effects of concentration on the SERS spectra of 6-PTU were analyzed. It shows that with the changes of the concentrations of 6-PTU, the SERS spectra of 6-PTU present significant changes, and it can be concluded that with the changing of concentrations, the orientation of 6-PTU on Au surface also changes. In addition, the SERS spectra of the interaction between 6-PTU and HSA show that the binding sites of 6-PTU to HSA are the functional groups N3H and C¼O. The information will not only be references to the study of the mechanism of the interaction between drugs and blood plasma or serum albumin but also a guidance to understand the metabolism of drugs in human body.

Section: Resultsmentioning

confidence: 99%

Characterization of 6‐propylthiouracil and its interaction with human serum albumin on Au surface by surface‐enhanced Raman scattering

2015

“…The SERS signal increases as the concentration of the adsorbate molecule is lowered, attains a maximum at a particular concentration or a particular range of concentrations and then decreases again with a further decrease in concentration. [60] It is now well established that on the silver colloidal surface a maximum enhancement of the Raman signal is observed when a monolayer of the adsorbate molecule is found on the surface, and as multilayers are formed the SERS signal decreases. [14,61] This conjecture assumes that the orientation of the molecule does not change with the surface coverage and the predicted behaviour holds for all the SERS bands.…”

Section: Concentration Dependence Of the Sers Spectra Of Sanamentioning

confidence: 99%

“…[14,61] This conjecture assumes that the orientation of the molecule does not change with the surface coverage and the predicted behaviour holds for all the SERS bands. [60] However, there have been a number of reports in recent years that suggest a change of orientation of the adsorbed molecule with surface coverage and therefore with adsorbate concentration in the sol. [62 -65] The effect of concentration on SERS in relation to the orientation of the molecule with respect to the metal surface has been reported.…”

Section: Concentration Dependence Of the Sers Spectra Of Sanamentioning

confidence: 99%

Concentration and pH dependent SERS spectra of sulfanilic acid sodium salt on colloidal silver particles

Panicker¹,

Varghese

Ushakumari³

et al. 2009

Self Cite

IR, Raman and surface-enhanced Raman scattering (SERS) spectra of sulfanilic acid sodium salt (SANA) were recorded and analysed. The vibrational wavenumbers were computed by the density functional theory method using the B3LYP/6-31G * basis and found to be in good agreement with the experimental values. The effect of concentration and pH dependence on the SERS intensity of the molecule was also studied. The molecular plane assumes a tilted orientation with respect to the silver surface. The observed changes of the relative intensities of some enhanced bands and the presence of in-plane and out-of-plane modes of the phenyl ring suggest that the molecule assumes a more tilted orientation upon lowering the concentration of the adsorbate.

“…The SERS signal increases as the concentration of the adsorbate molecule is lowered, attains a maximum at a particular concentration or a particular range of concentrations and then decreases again with a further decrease in concentration. 52 It is now well established that on the silver colloidal surface a maximum enhancement of the Raman signal is observed when a monolayer of the adsorbate molecule is formed on the surface, and as multilayers are formed the SERS signal decreases. 53,54 This conjecture assumes that the orientation of the molecule does not change with the surface coverage and the predicted behaviour holds for all the SERS bands.…”

Section: Sers Spectramentioning

confidence: 99%

“…53,54 This conjecture assumes that the orientation of the molecule does not change with the surface coverage and the predicted behaviour holds for all the SERS bands. 52 However, there have been a number of reports in recent years that suggest a change of orientation of the adsorbed molecule with surface coverage and therefore with adsorbate concentration in the sol. 55 -58 The effect of concentration on SERS in relation to the orientation of the molecule with respect to the metal surface has been reported.…”

Section: Sers Spectramentioning

confidence: 99%

IR, Raman and SERS spectra of 3,5‐dinitrosalicylic acid

Varghese

Panicker²,

Philip³

et al. 2006

Self Cite

IR, Raman and surface enhanced Raman scattering (SERS) spectra of 3,5-dinitrosalicylic acid (DNSA) were recorded and analysed. The vibrational wavenumbers were computed by the ab initio method using RHF/6-21G * basis and they were found to be in good agreement with the experimental values. The effect of the concentration dependence on the SERS intensity of the molecule was studied. The molecular plane assumes a tilted orientation with respect to the silver surface.