increased nutrient levels and algal blooms can also cause drinking water problems in communities near dead zones and upstream. humans, fish, marine mammals, birds, and other animals are all adversely affected by the toxins produced by toxic algal blooms. The purpose of this study is The effect of The combined system of Hydrodynamic Cavitation, Ozone (O3), and Hydrogen Peroxide (H2O2) on the removal of Chlorophyll a and Organic substances in the raw water entering the Sanandaj treatment plant. In this study, we examined the following variables: pH, Retention Time, Pressure, Distance, Ozone dose, and Hydrogen Peroxide dose. Utilizing Taguchi design methodology, experiments were planned and optimized. Chlorophyll a and Total Organic Carbon (TOC) can be removed most effectively under the following conditions: 5 bar of cavitation pressure, 90 min of retention time, a pH of 5, 1 m3/h of Flow, a distance of 25 cm from the orifice, 3 gr/h of ozone, and 2 gr/l of Hydrogen Peroxide. The most efficient factor in the degradation of TOC and Chlorophyll a was determined to be cavitation pressure based on the percentage contributions of each factor (38.64 percent and 35.05 percent, respectively). H2O2 was found to have the most negligible impact on degradation efficiency (4.24 percent and 4.11 percent, respectively).