Adsorption of Cetyldimethylbenzylammonium Chloride on Octane Emulsions Droplets: The Effect of the Presence of Tween 80

Avranas, Antonis; Malasidou, Efi; Mandrazidou, Irene

doi:10.1006/jcis.1998.5810

Cited by 19 publications

(10 citation statements)

References 22 publications

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“…The minimum areas per surfactant molecules corre spond to the formation of layers of vertically ori ented molecules; area values are close to the litera ture data [1,[18][19][20]. The composition of mixed surfactant adsorption layers were calculated from interfacial tension values using the Rosen model [1,21,22]. According to this model, adsorption layers are treated as separate phases in the state of thermodynamic equilibrium with solu tions.…”

Section: Resultsmentioning

confidence: 99%

The Distribution of mixtures of dodecyl ether of poly(23)ethylene glycol with sodium dodecyl sulfate and dodecyltrimethylammonium bromide in the water/octane system

Соболева

Pronchenko

Chernysheva

et al. 2012

Russ. J. Phys. Chem.

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The scintillation phase and tensiometry methods were used to study the mutual influence of dode cyl ether of poly(23)ethylene glycol (Brij 35) with sodium dodecyl sulfate and Brij 35 with dodecyltrimeth ylammonium bromide on the distribution in the water/octane system and adsorption at the liquid/liquid interface. The composition of mixed adsorption layers was determined and interaction parameters between molecules were calculated according to the Rosen model.

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Section: Resultsmentioning

confidence: 99%

The Distribution of mixtures of dodecyl ether of poly(23)ethylene glycol with sodium dodecyl sulfate and dodecyltrimethylammonium bromide in the water/octane system

Соболева

Pronchenko

Chernysheva

et al. 2012

Russ. J. Phys. Chem.

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“…Several mechanisms for the destabilization of Pickering emulsions upon surfactant addition have been previously proposed. In surfactant-stabilized emulsions, the introduction of a new surfactant potentially results in a competition for the interface, shifting the interface-bulk equilibrium of both surfactants [ 17 ], with the final interfacial stabilizer composition determined by the relative affinity of each agent for the surface versus the bulk phase. Under the present experimental conditions, GMS was a solid-state material, firmly bonded to the droplet surface, with the energy required for removal orders of magnitude larger than that required for liquid surfactants.…”

Section: Resultsmentioning

confidence: 99%

Oseltamivir phosphate released from injectable Pickering emulsions over an extended term disables human pancreatic cancer cell survival

et al. 2018

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Pickering emulsions are colloidal dispersions stabilized by particles that either migrate to, or are formed at, the oil-water interface during emulsification. Here, we fabricated and characterized Pickering water-in-oil emulsions where molten glycerol monostearate crystallized at the surface of micron-sized water droplets and formed protective solid shells. We tested this emulsion as a reservoir delivery platform for the sustained release of low molecular weight hydrophilic molecules including sodium chloride (NaCl) and sodium citrate as model compounds, and the therapeutic oseltamivir phosphate (OP), the delivery of which was the ultimate goal of this research. The objective was to achieve long-term (30-day) release of challenging to encapsulate actives and ultimately demonstrate the sustained release of OP for 20–30 days from an injectable formulation. OP was used because of its anticancer properties targeting mammalian neuraminidase 1 (Neu1) involved in multistage tumorigenesis. All actives including OP encapsulated in Pickering emulsions displayed a near linear release profile over 30 days. It was demonstrated that the release could be modulated by the addition of a second, competing surfactant sorbitan monooleate, Span 80, to the emulsion at levels above its critical micelle concentration. OP released from the emulsions significantly reduced cell viability in the human PANC-1 pancreatic cancer cell line for up to 30 days. The findings from this study indicate a simple, potentially injectable formulation and method that is easily upscaled resulting in a stable product with the potential to fully retain small hydrophilic molecules/drugs for sustained, near linear release over days, weeks, and potentially months.

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“…The detection limit achieved in this system was 3 counts s −1 , (S/N ratio of 3, with an estimated density of 0.0125 ± 0.0001 molecule/nm 2 or 80 ± 3 nm 2 /molecule, based on literature values for Γ max measured at the air−water interface from surface tension measurements; the actual value at the silica−water interface may be slightly different). 15 This value corresponds to the lowest detectable surface excess at a 0.5 μM surfactant concentration with metal salt addition (when extrapolating the signal intensity at the maximum relative surface coverage) and a fractional relative coverage of 0.075, assuming linear behavior between the Raman signal intensity and molecules adsorbed at the silica−water interface.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Cationic surfactants of this type are employed in 2 and 3° crude oil recovery, that is, hydraulic fracturing processes; they are found as constituents in corrosion inhibitors − or used for modulation of oil-wetting or water-wetting interfacial properties, , as well as control of adsorption to certain soil and rock formations. One representative surfactant of this type is benzyldimethylhexadecylammonium chloride (BDMHA + Cl – ), the compound of interest in the present study. − …”

Section: Introductionmentioning

confidence: 99%

“…The bulky benzyldimethyl ligand on the BDMHA + head group alters both thermodynamic and kinetic properties of a surfactant as compared to other homologues with small head groups, ,,, giving strong incentives to identify the relationship between the head group function and the surfactant adsorption behavior at an interface of interest, that is, a hydrophobic silica surface. Adsorption of BDMHA + Cl – at OTS-modified quartz surfaces was investigated in this study with the goal to evaluate the effects of hydrophobic surface properties on thermodynamic and kinetic adsorption parameters in contrast to the previously studied adsorption behavior of the same surfactant at the bare, hydrophilic silica. ,− Adsorption trends at a hydrophobic silica surface are of interest because quartz or silica surfaces may be altered by nonpolar hydrocarbon-rich deposits. , In addition, the wettability of hydrophobic surfaces and solubilization of nonpolar mixtures are desirable in many interfacial processes. ,,− One important aspect of surfactant formulation in these application areas is optimum surfactant performance at low production costs and minimum adverse effects on the environment. , …”

Section: Introductionmentioning

confidence: 99%

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Adsorption of Benzyldimethylhexadecylammonium Chloride at the Hydrophobic Silica–Water Interface Studied by Total Internal Reflection Raman Spectroscopy: Effects of Silica Surface Properties and Metal Salt Addition

Grenoble

Baldelli

2013

J. Phys. Chem. B

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The adsorption of the cationic surfactant benzyldimethylhexadecylammonium (BDMHA(+)) chloride was studied at an octadecyltrichlorosilane (OTS)-monolayer-modified silica-water interface by Raman spectroscopy in total internal reflection (TIR) geometry. The present study demonstrates the capabilities of this spectroscopic technique to evaluate thermodynamic and kinetic BDMHA(+)Cl(-) adsorption properties at the hydrophobic silica surface. The surface coverage of BDMHA(+) decreased by 50% at the hydrophobic OTS-silica surface relative to the surface coverage on bare silica; the dominating driving mechanisms for surfactant adsorption were identified as hydrophobic effects and head group charge screening by the electrolyte counterions. Addition of magnesium metal salt (MgCl2) to the aqueous solution (∼ neutral pH) lowered the surface coverage and moderately increased the Langmuir adsorption constants relative to those of the pure surfactant. These trends were previously observed at the hydrophilic, negatively charged silica surface but with a smaller change in the Gibbs free energy of adsorption at the hydrophobic silica surface. The hydrophobic OTS-silica surface properties resulted in shorter times for the surfactant to reach steady-state adsorption conditions compared to the slow adsorption kinetics previously seen with the surfactant at the hydrophilic surface. Adsorption isotherms, based on Raman signal intensities from spectral analysis, were developed according to the Langmuir adsorption model for the pure surfactant at the OTS-silica-water interface; the modified Langmuir model was applied to the surfactant adsorption in the presence of 5, 10, 50, and 100 mM magnesium chloride. Spectral analysis of the Raman scattering intensities and geometric considerations suggests a hemimicelle-type surface aggregate as the most likely surfactant structure at the OTS-silica surface. The different kinetics observed at the hydrophilic versus the hydrophobic silica surface further indicate that the surface charge and potential influence the surfactant diffusion and kinetic rates of adsorption at the silica-water interface.

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Adsorption of Cetyldimethylbenzylammonium Chloride on Octane Emulsions Droplets: The Effect of the Presence of Tween 80

Cited by 19 publications

References 22 publications

The Distribution of mixtures of dodecyl ether of poly(23)ethylene glycol with sodium dodecyl sulfate and dodecyltrimethylammonium bromide in the water/octane system

The Distribution of mixtures of dodecyl ether of poly(23)ethylene glycol with sodium dodecyl sulfate and dodecyltrimethylammonium bromide in the water/octane system

Oseltamivir phosphate released from injectable Pickering emulsions over an extended term disables human pancreatic cancer cell survival

Adsorption of Benzyldimethylhexadecylammonium Chloride at the Hydrophobic Silica–Water Interface Studied by Total Internal Reflection Raman Spectroscopy: Effects of Silica Surface Properties and Metal Salt Addition

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