A novel sonocatalyst, Er(3+):Y3Al5O12/KNbO3 composite, was synthesized, and then, characterized by X-ray diffractometer (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). In order to evaluate the sonocatalytic activity of prepared Er(3+):Y3Al5O12/KNbO3 composite, the sonocatalytic degradation of ketamine, a kind of narcotic drug, was studied. In addition, some influencing factors such as mass ratio, heat-treated temperature and heat-treated time on the sonocatalytic activity of prepared Er(3+):Y3Al5O12/KNbO3 powders and ultrasonic irradiation time on the sonocatalytic degradation of ketamine were examined by using GC-MS machine. The experimental results showed that the Er(3+):Y3Al5O12/KNbO3 composite is a good sonocatalyst in the field of ultrasonic chemistry and the sonocatalytic degradation was an effective method for the innocent treatment of ketamine.