2008
DOI: 10.1016/j.diabres.2008.02.013
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Adsorption of insulin onto infusion sets used in adult intensive care unit and neonatal care settings

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Cited by 38 publications
(65 citation statements)
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“…Insulin adsorption can also be decreased by infusing insulin solutions with a higher concentration or at higher rates. 5,7,9,12,13 These methods may not be possible in patients requiring small titrations, such as infants and small children, or those who cannot tolerate high fluid volumes. Flushing the intravenous tubing with insulin or dwelling the insulin solution within the tubing for a period of time prior to the start of therapy also decreases adsorption losses by saturating binding sites within the tubing.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Insulin adsorption can also be decreased by infusing insulin solutions with a higher concentration or at higher rates. 5,7,9,12,13 These methods may not be possible in patients requiring small titrations, such as infants and small children, or those who cannot tolerate high fluid volumes. Flushing the intravenous tubing with insulin or dwelling the insulin solution within the tubing for a period of time prior to the start of therapy also decreases adsorption losses by saturating binding sites within the tubing.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] Insulin adsorption lowers the concentration of insulin delivered to the patient within the first 6-22 h of an infusion, which can be clinically significant. 5,[7][8][9] Different strategies have been proposed to minimize insulin adsorption. Priming tubing with albumin or whole blood prior to initiating an insulin infusion decreases adsorption 5,10,11 ; however, this method unnecessarily exposes patients to blood products.…”
Section: Introductionmentioning
confidence: 99%
“…At 0.1 mL/h the initially measured concentration was 54.19% after 180 min. At either flow rate, the concentration of insulin had not reached 100% of the syringe concentration after 24 h [8]. Moreover, the sorption of drugs to infusion materials may have clinical consequences by physically affecting the materials themselves, which may lead to changes in mechanical properties and biocompatibility [49,50].…”
Section: Container-content Interactionmentioning
confidence: 99%
“…Moreover, the sorption of drugs to infusion materials may have clinical consequences by physically affecting the materials themselves, which may lead to changes in mechanical properties and biocompatibility [49,50]. Drugs affected by this problem include, non-exhaustively, nitroglycerin [51], isosorbide dinitrate [52], diazepam [53], chlorpromazine [54], vitamin A [55] and insulin [8,56].…”
Section: Container-content Interactionmentioning
confidence: 99%
“…[4][5][6] Significant adsorption was also observed during administration of undiluted protein drug products. 7,8 Current pharmaceutical regulations require that i.v.-delivered medications be consistently within 10% of the nominal concentration. [9][10][11] Thus, protein loss due to adsorption onto containers, filters, and tubing used for administration must be investigated and addressed in parallel with the formulation development efforts, particularly for low-dose products.…”
Section: Introductionmentioning
confidence: 99%