Adsorption of technetium-99m tetrofosmin and technetium-99m furifosmin on plastic syringes

Bartosch, Rainer; Granegger, Susanne; Sinzinger, H.

doi:10.1007/s002590050304

Cited by 14 publications

(10 citation statements)

References 2 publications

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“…The residual doses that we observed here were on average lower than those for 99m Tc-sestamibi that were observed in the MILLISIEVERT study, in which residual activity for a similar ULD injection averaged 64 MBq and ranged from 6.3 to 144 MBq (9). Although limited data suggest that tetrofosmin may be less adsorptive than some other 99m Tc-based radiopharmaceuticals (22), numerous factors influence 99m Tc residual activity, including not just the particular radiopharmaceutical but also the type of syringe and length of time the radiopharmaceutical is in the syringe before injection (23,24). The determinants of residual activity for ULD injections is a subject that requires further study.…”

Section: Discussioncontrasting

confidence: 68%

Radiation Dose and Prognosis of Ultra-Low-Dose Stress-First Myocardial Perfusion SPECT in Patients with Chest Pain Using a High-Efficiency Camera

et al. 2015

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Although SPECT myocardial perfusion imaging (MPI) provides valuable information about patients with chest pain, there is growing concern regarding its radiation burden and lengthy duration. New high-efficiency (HE) cameras and stress-first protocols both offer the potential to markedly reduce radiation. No previous study has assessed outcomes and radiation doses of patients undergoing MPI on an HE-SPECT camera using an ultra-low-dose stress-first protocol. Methods: One hundred patients presenting to the emergency department with chest pain who were candidates for stress-first MPI underwent injection of approximately 185 MBq (5 mCi) of 99m Tctetrofosmin at peak stress, followed by supine and prone imaging on an HE-SPECT camera. Same-day rest imaging was performed on patients with any abnormality on imaging after stress. Radiation effective dose was calculated from administered and residual activities. Patients were contacted 3 mo after discharge, and electronic records were accessed to evaluate the need for reevaluation for chest pain, additional imaging, or cardiac events. Results: Stress-only imaging was performed in 69 patients, for whom radiation effective dose averaged 0.99 mSv and study duration, 117 min. Radiation dose averaged 2.22 mSv over all patients. At 3 mo, 96 patients were free of major adverse cardiac events, repeat hospital chest pain evaluation, and repeat imaging or stress testing. One year after MPI and hospital discharge, all patients were living and without acute coronary syndrome. Conclusion: HE-SPECT stress-only imaging can be performed in more than two thirds of chest pain patients without a high pretest probability of a stress perfusion defect, with excellent prognosis, a radiation dose averaging 1 mSv, and a test duration of less than 2 h.

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Section: Discussioncontrasting

confidence: 68%

Radiation Dose and Prognosis of Ultra-Low-Dose Stress-First Myocardial Perfusion SPECT in Patients with Chest Pain Using a High-Efficiency Camera

et al. 2015

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“…Several authors report that, in their hands, the adsorption of a substantial number of tracers to the syringe was below 3-4%, which was seemingly not affected by the syringe brand [3,4]. Several authors report that, in their hands, the adsorption of a substantial number of tracers to the syringe was below 3-4%, which was seemingly not affected by the syringe brand [3,4].…”

mentioning

confidence: 99%

Retention of 99mTc-DMSA(III) and 99mTc-nanocolloid in different syringes affects imaging quality

Bauwens

Pooters²,

Pol³

et al. 2014

Nuclear Medicine Communications

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(99m)Tc-dimercaptosuccinic acid [DMSA(III)] and colloidal human serum albumin ((99m)Tc-nanocolloid) are widely used radiopharmaceuticals. Recently, in our institution we encountered image quality problems in DMSA scans after changing the brand of syringes we were using, which triggered us to look into the adsorption properties of syringes from different brands for (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid. We also describe a clinical case in which adsorption of (99m)Tc-DMSA(III) caused inferior imaging quality. DMSA and nanocolloid were labeled with (99m)Tc following manufacturer guidelines. After synthesis, syringes with (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid were stored for 15, 30, 60, and 120 min. We evaluated Luer Lock syringes manufactured by different brands such as Artsana, Henke-Sass-Wolf, B. Braun Medical N.V., CODAN Medizinische Geräte GmbH & Co KG, Becton Dickinson and Company, and Terumo Europe. Adsorption of (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid was acceptably low for all syringes (<13%), except for two brands with (99m)Tc-DMSA(III) adsorption rates of 36 and 30%, respectively, and for one brand with a (99m)Tc-nanocolloid adsorption rate of 27%. Adsorption of (99m)Tc-DMSA(III) and (99m)Tc-nanocolloid reaches critical levels in syringes produced by two brands, potentially causing poor image quality--for example, in DMSA scans using pediatric radiopharmaceutical doses. It is advised to check the compatibility of any radiopharmaceutical with syringes as an integral part of the quality assurance program.

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“…The adsorption behavior of some radiopharmaceuticals on glass vials has been studied (3,4). The adsorption of 99m Tc-methylene diphosphonate, 99m Tc-sestamibi, 99m Tc-tetrofosmin, 99m Tc-furifosmin, and 99m Tc-macroaggregated albumin on plastic syringes has also been reported (5,6).…”

mentioning

confidence: 99%

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

Ahmad¹,

Rehman²,

Mansur³

et al. 2008

Journal of Nuclear Medicine Technology

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Many groups have reported the adsorption or retention of 99m Tcradiopharmaceuticals on injection vials and disposable plastic syringes. Such an enormously high loss of radioactivity would result in poor images, radiation exposure, waste, and economic burdens. We therefore decided to investigate the extent of adsorption or retention of several 99m Tc-radiopharmaceuticals on injection vials, rubber stoppers, and plastic syringes. These radiopharmaceuticals are produced as lyophilized kits in our department and supplied to various hospitals practicing nuclear medicine in Pakistan. Methods: A vial containing lyophilized material was reconstituted with 3 mL of freshly eluted Na 99m TcO 4 . A 1-mL aliquot of the resulting solution was withdrawn into a syringe at 0.25, 0.5, 1, 3, and 5 h after preparation. All preparations were stored at room temperature (;22°C). After each withdrawal, the vial was reweighed and the activity remaining in the vial was measured using a radioisotope calibrator. The sample was reinjected into the vial. From the original weight and activity of solution in the vial, the initial activity per gram was calculated. From the weight and activity remaining in the vial after withdrawal of the sample, the activity per gram of the sample was calculated. From the difference between the initial activity per gram and the activity per gram of the sample, the percentage of 99m Tc adsorbed on the vial was calculated. All preparations were kept in the syringe for 15 min, and the activity was measured before and after the syringe was emptied. The needle and plunger of the syringe were separated, and activity in the needle and plunger was also measured. Results: The labeling efficiency of all radiopharmaceuticals used during these studies was more than 95%. In most cases, the activity of 99m Tc found on the rubber stopper was less than 1%. Adsorption of 99m Tc onto vials increased gradually with storage time. Adsorption was minimal at the initial stages, whereas maximum retention was noted after 5 h. Nearly 5% adsorption of activity was observed after 5 h of storage time on vials of sestamibi, mercaptoacetyltriglycine, dextran, ciprofloxacin, and dimercaptosuccinic acid (III and V). Retention of activity on needles ranged from 1% to 2% for all preparations studied. Plungers did not show any significant retention of radioactivity; in most cases, retention was less than 0.5%. The maximum retention of radioactivity on plastic syringe bodies was more than 3% for sestamibi, dimercaptosuccinic acid, dextran, pyrophosphate, and phytate. Conclusion: The results revealed that losses of radioactivity from 99m Tc-radiopharmaceuticals in these objects (glass vial, rubber stopper, plastic syringes, plungers, and needles) are not alarming in our setup.

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Adsorption of technetium-99m tetrofosmin and technetium-99m furifosmin on plastic syringes

Cited by 14 publications

References 2 publications

Radiation Dose and Prognosis of Ultra-Low-Dose Stress-First Myocardial Perfusion SPECT in Patients with Chest Pain Using a High-Efficiency Camera

Radiation Dose and Prognosis of Ultra-Low-Dose Stress-First Myocardial Perfusion SPECT in Patients with Chest Pain Using a High-Efficiency Camera

Retention of 99mTc-DMSA(III) and 99mTc-nanocolloid in different syringes affects imaging quality

Adsorption of 99mTc-Radiopharmaceuticals onto Injection Vials and Syringes

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