Adsorption Techniques: Dialysis Sorbents and Membranes

Perego, A

doi:10.1159/000350848

Cited by 13 publications

(13 citation statements)

References 12 publications

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“…These protein-bound uremic toxins have been shown to have endothelial toxicity and inhibit endothelial proliferation [55] . Adsorption-based dialysis techniques and novel membranes need to be developed and evaluated for their capacity to more efficiently remove uremic toxins [56,57] .…”

Section: Discussionmentioning

confidence: 99%

T-Cell Activation and Malnutrition Adversely Impact on Endothelial Progenitor Cell Mobilization in Patients on Extracorporeal Maintenance Dialysis Therapy

Tuaillon

Jaussent

Moréna³

et al. 2015

Blood Purif

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Background: The number of circulating endothelial progenitor cells (EPCs) decreases on account of chronic kidney disease (CKD). Methods: Twenty patients were enrolled in this prospective and randomised study in two parallel arms: conventional haemodialysis versus online haemodiafiltration. EPCs number and T-cell activation were analysed at baseline and monthly during a 4-month period of follow-up. Results: CD38^bright and HLA-DR+ expression among CD8 memory T cells were negatively associated with both CD34+ (r = -0.70, p = 0.0006) and CD34+ CD133+ (r = -0.62, p = 0.004) cell numbers. Conversely, a positive correlation was observed between CD34+ and CD34+ CD133+ cells with transferrin (r = 0.75, p = 0.0001 and r = 0.47, p = 0.04, respectively), and CD34+ CD133+ cells with transthyretin (r = 0.51, p = 0.02). No significant association was observed between dialysis modality and the evolution of the EPC number. Conclusions: Chronic T-cell activation may be a component of the malnutrition inflammation complex syndrome that adversely influences EPC mobilization in CKD patients.

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Section: Discussionmentioning

confidence: 99%

T-Cell Activation and Malnutrition Adversely Impact on Endothelial Progenitor Cell Mobilization in Patients on Extracorporeal Maintenance Dialysis Therapy

Tuaillon

Jaussent

Moréna³

et al. 2015

Blood Purif

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“…The adsorptive capacity for low-molecular-weight plasma proteins varies among different hemofilter membrane materials [35,56,57]. Adsorptive clearances for middle molecules are time-dependent, with maximum values occurring in the first few hours of therapy [58].…”

Section: Drug Adsorption Clearance In Continuous Renal Replacement Thmentioning

confidence: 99%

“…The degree of protein binding is the most important factor influencing whether a drug needs dose adjustment during CRRT. Drugs that are more than 90% bound to plasma proteins are unlikely to be removed by hemodialysis and hemofiltration [27-31], but the adsorption on the membrane in the filter could result in a significant clearance [32-35]. …”

Section: Introductionmentioning

confidence: 99%

Treatment with echinocandins during continuous renal replacement therapy

2014

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Echinocandins are indicated as first-line treatment for invasive candidiasis in moderate to severe illness. As sepsis is the main cause of acute kidney injury, the combination of echinocandin treatment and continuous renal replacement therapy (CRRT) is common. Optimizing antibiotic dosage in critically ill patients receiving CRRT is challenging. The pharmacokinetics of echinocandins have been studied under various clinical conditions; however, data for CRRT patients are scarce. Classically, drugs like echinocandins with high protein binding and predominantly non-renal elimination are not removed by CRRT, indicating that no dosage adjustment is required. However, recent studies report different proportions of echinocandins lost by filter adsorption. Nevertheless, the clinical significance of these findings remains unclear.

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“…It is not known whether the results obtained are unique to CytoSorb or represent a “class-effect”. Many other adsorptive materials have been designed to remove inflammatory cytokines [13,14] and may also work to remove other injurious molecules. One such material is CTR, a sorbent, composed of porous cellulose beads to which a hydrophobic organic compound with a hexadecyl alkyl chain has been covalently bound to the surface (Kaneka Corp., Osaka, Japan).…”

Section: Introductionmentioning

confidence: 99%

Effects of Hemoadsorption with a Novel Adsorbent on Sepsis: In vivo and in vitro Study

Zhang¹,

Peng²,

Maberry³

et al. 2015

Blood Purif

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Background/Aims: Hemoadsorption may improve outcomes for sepsis by removing circulating cytokines. We tested a new sorbent used for hemoadsorption. Methods: CTR sorbent beads were filled into columns of three sizes: CTR0.5 (0.5 ml), CTR1 (1.0 ml) and CTR2 (2.0 ml) and tested using IL-6 capture in vitro. Next, rats were subjected to cecal ligation and puncture and randomly assigned to hemoadsorption with CTR0.5, CTR1, CTR2 or sham treatment. Plasma biomarkers were measured. Results: In vitro, IL-6 removal was accelerated with increasing bead mass. In vivo, TNF, IL-6, IL-10, high mobility group box1, and cystatin C were significantly lower 24 h after CTR2 treatment. Seven-day survival rate was 50, 64, 63, and 73% for the sham, CTR0.5, CTR1, CTR2, respectively. Conclusion: CTR appeared to have a favorable effect on kidney function despite no immediate effects on cytokine removal. However, CTR2 beads did result in a late decrease of cytokines.

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Adsorption Techniques: Dialysis Sorbents and Membranes

Cited by 13 publications

References 12 publications

T-Cell Activation and Malnutrition Adversely Impact on Endothelial Progenitor Cell Mobilization in Patients on Extracorporeal Maintenance Dialysis Therapy

T-Cell Activation and Malnutrition Adversely Impact on Endothelial Progenitor Cell Mobilization in Patients on Extracorporeal Maintenance Dialysis Therapy

Treatment with echinocandins during continuous renal replacement therapy

Effects of Hemoadsorption with a Novel Adsorbent on Sepsis: In vivo and in vitro Study

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